Plasma Adipsin as a Biomarker and Its Implication in Type 2 Diabetes Mellitus
Gebrehiwot Gebremedhin Tafere, Dawit Zewdu Wondafrash, Kaleab Alemayehu Zewdie, Brhane Teklebrhan Assefa, Muluken Altaye Ayza Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, EthiopiaCorrespondence: Gebrehiwot Gebremedhin TafereDepartment of Pharmacology an...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-05-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
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| Online Access: | https://www.dovepress.com/plasma-adipsin-as-a-biomarker-and-its-implication-in-type-2-diabetes-m-peer-reviewed-article-DMSO |
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| author | Tafere GG Wondafrash DZ Zewdie KA Assefa BT Ayza MA |
| author_facet | Tafere GG Wondafrash DZ Zewdie KA Assefa BT Ayza MA |
| author_sort | Tafere GG |
| collection | DOAJ |
| description | Gebrehiwot Gebremedhin Tafere, Dawit Zewdu Wondafrash, Kaleab Alemayehu Zewdie, Brhane Teklebrhan Assefa, Muluken Altaye Ayza Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, EthiopiaCorrespondence: Gebrehiwot Gebremedhin TafereDepartment of Pharmacology and Toxicology,School of Pharmacy, Mekelle University, P.O. Box: 1871, Mekelle, EthiopiaTel +251 908822323Email gebrehiwotg07@gmail.comAbstract: Diabetes mellitus (DM) is a worldwide health threat affecting millions of people, which is associated with different micro- and macro-vascular complications. Type 2 diabetes mellitus (T2DM) is one of the different types of DM caused by insulin resistance and/or reduced secretion of insulin from the pancreas. A validated novel biomarker is required to enhance the accuracy of disease prediction, provide novel insights into pathophysiology and contribute to future prevention of T2DM. Various newer diagnostic methods have been developed by targeting endogenous proteins among which Adipsin is one of the promising target. Therefore, this review discusses Adipsin as a potential biomarker and its implication in T2DM. Adipsin is one of the adipokines secreted by adipose tissues which is involved in maintaining adipose tissue homeostasis and increasing insulin secretion in response to glucose. According to different experimental and clinical studies, plasma Adipsin concentrations are low in animals and patients with DM which support its use as a biomarker in combination to the other diagnostic modalities for DM. Additionally, the existence of Adipsin could be important in improving hyperglycemia by preserving β-cell mass through improving β-cell survival and maintaining their transcriptional identity.Keywords: adipsin, type 2 diabetes mellitus, biomarker |
| first_indexed | 2024-04-10T18:10:03Z |
| format | Article |
| id | doaj.art-169c311a190547a9b9cc3b5da5b28bda |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T18:10:03Z |
| publishDate | 2020-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-169c311a190547a9b9cc3b5da5b28bda2023-02-02T11:19:39ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072020-05-01Volume 131855186154150Plasma Adipsin as a Biomarker and Its Implication in Type 2 Diabetes MellitusTafere GGWondafrash DZZewdie KAAssefa BTAyza MAGebrehiwot Gebremedhin Tafere, Dawit Zewdu Wondafrash, Kaleab Alemayehu Zewdie, Brhane Teklebrhan Assefa, Muluken Altaye Ayza Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, EthiopiaCorrespondence: Gebrehiwot Gebremedhin TafereDepartment of Pharmacology and Toxicology,School of Pharmacy, Mekelle University, P.O. Box: 1871, Mekelle, EthiopiaTel +251 908822323Email gebrehiwotg07@gmail.comAbstract: Diabetes mellitus (DM) is a worldwide health threat affecting millions of people, which is associated with different micro- and macro-vascular complications. Type 2 diabetes mellitus (T2DM) is one of the different types of DM caused by insulin resistance and/or reduced secretion of insulin from the pancreas. A validated novel biomarker is required to enhance the accuracy of disease prediction, provide novel insights into pathophysiology and contribute to future prevention of T2DM. Various newer diagnostic methods have been developed by targeting endogenous proteins among which Adipsin is one of the promising target. Therefore, this review discusses Adipsin as a potential biomarker and its implication in T2DM. Adipsin is one of the adipokines secreted by adipose tissues which is involved in maintaining adipose tissue homeostasis and increasing insulin secretion in response to glucose. According to different experimental and clinical studies, plasma Adipsin concentrations are low in animals and patients with DM which support its use as a biomarker in combination to the other diagnostic modalities for DM. Additionally, the existence of Adipsin could be important in improving hyperglycemia by preserving β-cell mass through improving β-cell survival and maintaining their transcriptional identity.Keywords: adipsin, type 2 diabetes mellitus, biomarkerhttps://www.dovepress.com/plasma-adipsin-as-a-biomarker-and-its-implication-in-type-2-diabetes-m-peer-reviewed-article-DMSOadipsintype2 diabetes mellitusbiomarker |
| spellingShingle | Tafere GG Wondafrash DZ Zewdie KA Assefa BT Ayza MA Plasma Adipsin as a Biomarker and Its Implication in Type 2 Diabetes Mellitus Diabetes, Metabolic Syndrome and Obesity adipsin type2 diabetes mellitus biomarker |
| title | Plasma Adipsin as a Biomarker and Its Implication in Type 2 Diabetes Mellitus |
| title_full | Plasma Adipsin as a Biomarker and Its Implication in Type 2 Diabetes Mellitus |
| title_fullStr | Plasma Adipsin as a Biomarker and Its Implication in Type 2 Diabetes Mellitus |
| title_full_unstemmed | Plasma Adipsin as a Biomarker and Its Implication in Type 2 Diabetes Mellitus |
| title_short | Plasma Adipsin as a Biomarker and Its Implication in Type 2 Diabetes Mellitus |
| title_sort | plasma adipsin as a biomarker and its implication in type 2 diabetes mellitus |
| topic | adipsin type2 diabetes mellitus biomarker |
| url | https://www.dovepress.com/plasma-adipsin-as-a-biomarker-and-its-implication-in-type-2-diabetes-m-peer-reviewed-article-DMSO |
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