A Perspective on Therapeutic Pan-Resistance in Metastatic Cancer
Metastatic spread represents the leading cause of disease-related mortality among cancer patients. Many cancer patients suffer from metastatic relapse years or even decades after radical surgery for the primary tumor. This clinical phenomenon is explained by the early dissemination of cancer cells f...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/19/7304 |
| _version_ | 1797551915582619648 |
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| author | Dimitrios Korentzelos Amanda M. Clark Alan Wells |
| author_facet | Dimitrios Korentzelos Amanda M. Clark Alan Wells |
| author_sort | Dimitrios Korentzelos |
| collection | DOAJ |
| description | Metastatic spread represents the leading cause of disease-related mortality among cancer patients. Many cancer patients suffer from metastatic relapse years or even decades after radical surgery for the primary tumor. This clinical phenomenon is explained by the early dissemination of cancer cells followed by a long period of dormancy. Although dormancy could be viewed as a window of opportunity for therapeutic interventions, dormant disseminated cancer cells and micrometastases, as well as emergent outgrowing macrometastases, exhibit a generalized, innate resistance to chemotherapy and even immunotherapy. This therapeutic pan-resistance, on top of other adaptive responses to targeted agents such as acquired mutations and lineage plasticity, underpins the current difficulties in eradicating cancer. In the present review, we attempt to provide a framework to understand the underlying biology of this major issue. |
| first_indexed | 2024-03-10T15:51:28Z |
| format | Article |
| id | doaj.art-169e4b187c4944fbbe185e6a9fd04085 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T15:51:28Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-169e4b187c4944fbbe185e6a9fd040852023-11-20T15:57:38ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-10-012119730410.3390/ijms21197304A Perspective on Therapeutic Pan-Resistance in Metastatic CancerDimitrios Korentzelos0Amanda M. Clark1Alan Wells2Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USADepartment of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USADepartment of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USAMetastatic spread represents the leading cause of disease-related mortality among cancer patients. Many cancer patients suffer from metastatic relapse years or even decades after radical surgery for the primary tumor. This clinical phenomenon is explained by the early dissemination of cancer cells followed by a long period of dormancy. Although dormancy could be viewed as a window of opportunity for therapeutic interventions, dormant disseminated cancer cells and micrometastases, as well as emergent outgrowing macrometastases, exhibit a generalized, innate resistance to chemotherapy and even immunotherapy. This therapeutic pan-resistance, on top of other adaptive responses to targeted agents such as acquired mutations and lineage plasticity, underpins the current difficulties in eradicating cancer. In the present review, we attempt to provide a framework to understand the underlying biology of this major issue.https://www.mdpi.com/1422-0067/21/19/7304metastasisdisseminated tumor cellse-cadherintherapy resistancedormancymetastatic microenvironment |
| spellingShingle | Dimitrios Korentzelos Amanda M. Clark Alan Wells A Perspective on Therapeutic Pan-Resistance in Metastatic Cancer International Journal of Molecular Sciences metastasis disseminated tumor cells e-cadherin therapy resistance dormancy metastatic microenvironment |
| title | A Perspective on Therapeutic Pan-Resistance in Metastatic Cancer |
| title_full | A Perspective on Therapeutic Pan-Resistance in Metastatic Cancer |
| title_fullStr | A Perspective on Therapeutic Pan-Resistance in Metastatic Cancer |
| title_full_unstemmed | A Perspective on Therapeutic Pan-Resistance in Metastatic Cancer |
| title_short | A Perspective on Therapeutic Pan-Resistance in Metastatic Cancer |
| title_sort | perspective on therapeutic pan resistance in metastatic cancer |
| topic | metastasis disseminated tumor cells e-cadherin therapy resistance dormancy metastatic microenvironment |
| url | https://www.mdpi.com/1422-0067/21/19/7304 |
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