Mesenchymal stromal/stem cells and bronchopulmonary dysplasia
Bronchopulmonary dysplasia (BPD) is a common complication in preterm infants, leading to chronic respiratory disease. There has been an improvement in perinatal care, but many infants still suffer from impaired branching morphogenesis, alveolarization, and pulmonary capillary formation, causing lung...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1247339/full |
| _version_ | 1797645755119304704 |
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| author | Shuqing Zhang Cassidy Mulder Suzette Riddle Rui Song Dongmei Yue |
| author_facet | Shuqing Zhang Cassidy Mulder Suzette Riddle Rui Song Dongmei Yue |
| author_sort | Shuqing Zhang |
| collection | DOAJ |
| description | Bronchopulmonary dysplasia (BPD) is a common complication in preterm infants, leading to chronic respiratory disease. There has been an improvement in perinatal care, but many infants still suffer from impaired branching morphogenesis, alveolarization, and pulmonary capillary formation, causing lung function impairments and BPD. There is an increased risk of respiratory infections, pulmonary hypertension, and neurodevelopmental delays in infants with BPD, all of which can lead to long-term morbidity and mortality. Unfortunately, treatment options for Bronchopulmonary dysplasia are limited. A growing body of evidence indicates that mesenchymal stromal/stem cells (MSCs) can treat various lung diseases in regenerative medicine. MSCs are multipotent cells that can differentiate into multiple cell types, including lung cells, and possess immunomodulatory, anti-inflammatory, antioxidative stress, and regenerative properties. MSCs are regulated by mitochondrial function, as well as oxidant stress responses. Maintaining mitochondrial homeostasis will likely be key for MSCs to stimulate proper lung development and regeneration in Bronchopulmonary dysplasia. In recent years, MSCs have demonstrated promising results in treating and preventing bronchopulmonary dysplasia. Studies have shown that MSC therapy can reduce inflammation, mitochondrial impairment, lung injury, and fibrosis. In light of this, MSCs have emerged as a potential therapeutic option for treating Bronchopulmonary dysplasia. The article explores the role of MSCs in lung development and disease, summarizes MSC therapy’s effectiveness in treating Bronchopulmonary dysplasia, and delves into the mechanisms behind this treatment. |
| first_indexed | 2024-03-11T14:51:30Z |
| format | Article |
| id | doaj.art-169f50ad18704e89a26094f1b7da107f |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-03-11T14:51:30Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-169f50ad18704e89a26094f1b7da107f2023-10-30T09:22:52ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-10-011110.3389/fcell.2023.12473391247339Mesenchymal stromal/stem cells and bronchopulmonary dysplasiaShuqing Zhang0Cassidy Mulder1Suzette Riddle2Rui Song3Dongmei Yue4School of Pharmacy, China Medical University, Shenyang, ChinaLiberty University College of Osteopathic Medicine, Lynchburg, VA, United StatesCardiovascular Pulmonary Research Laboratories, Departments of Pediatrics and Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United StatesLawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, United StatesDepartment of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaBronchopulmonary dysplasia (BPD) is a common complication in preterm infants, leading to chronic respiratory disease. There has been an improvement in perinatal care, but many infants still suffer from impaired branching morphogenesis, alveolarization, and pulmonary capillary formation, causing lung function impairments and BPD. There is an increased risk of respiratory infections, pulmonary hypertension, and neurodevelopmental delays in infants with BPD, all of which can lead to long-term morbidity and mortality. Unfortunately, treatment options for Bronchopulmonary dysplasia are limited. A growing body of evidence indicates that mesenchymal stromal/stem cells (MSCs) can treat various lung diseases in regenerative medicine. MSCs are multipotent cells that can differentiate into multiple cell types, including lung cells, and possess immunomodulatory, anti-inflammatory, antioxidative stress, and regenerative properties. MSCs are regulated by mitochondrial function, as well as oxidant stress responses. Maintaining mitochondrial homeostasis will likely be key for MSCs to stimulate proper lung development and regeneration in Bronchopulmonary dysplasia. In recent years, MSCs have demonstrated promising results in treating and preventing bronchopulmonary dysplasia. Studies have shown that MSC therapy can reduce inflammation, mitochondrial impairment, lung injury, and fibrosis. In light of this, MSCs have emerged as a potential therapeutic option for treating Bronchopulmonary dysplasia. The article explores the role of MSCs in lung development and disease, summarizes MSC therapy’s effectiveness in treating Bronchopulmonary dysplasia, and delves into the mechanisms behind this treatment.https://www.frontiersin.org/articles/10.3389/fcell.2023.1247339/fullstem cellsbronchopulmonary dysplasiadevelopmentextracellular vesiclesmitochondria |
| spellingShingle | Shuqing Zhang Cassidy Mulder Suzette Riddle Rui Song Dongmei Yue Mesenchymal stromal/stem cells and bronchopulmonary dysplasia Frontiers in Cell and Developmental Biology stem cells bronchopulmonary dysplasia development extracellular vesicles mitochondria |
| title | Mesenchymal stromal/stem cells and bronchopulmonary dysplasia |
| title_full | Mesenchymal stromal/stem cells and bronchopulmonary dysplasia |
| title_fullStr | Mesenchymal stromal/stem cells and bronchopulmonary dysplasia |
| title_full_unstemmed | Mesenchymal stromal/stem cells and bronchopulmonary dysplasia |
| title_short | Mesenchymal stromal/stem cells and bronchopulmonary dysplasia |
| title_sort | mesenchymal stromal stem cells and bronchopulmonary dysplasia |
| topic | stem cells bronchopulmonary dysplasia development extracellular vesicles mitochondria |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1247339/full |
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