Small-Molecule Inhibitors of the RNA M6A Demethylases FTO Potently Support the Survival of Dopamine Neurons

Small-Molecule Inhibitors of the RNA M6A Demethylases FTO Potently Support the Survival of Dopamine Neurons

The fat mass and obesity-associated protein (FTO), an RNA N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) demethylase, is an important regulator of central nervous system development, neuronal signaling and disease. We present here the target-tailored development and biologica...

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Bibliographic Details
Main Authors: Simona Selberg, Li-Ying Yu, Olesja Bondarenko, Esko Kankuri, Neinar Seli, Vera Kovaleva, Koit Herodes, Mart Saarma, Mati Karelson
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
FTO
ALKBH5
m6A
RNA
drug design
dopamine neurons
Online Access:https://www.mdpi.com/1422-0067/22/9/4537

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