Solventless Lactam Synthesis by Intramolecular Cyclizations of α-Iminoester Derivatives under Microwave Irradiation
We have previously reported a new synthesis of amides from esters and amines under microwave irradiation, offering much higher yields than those achieved with conventional heating [1]. We have now extended these studies to the ring closure of neat iminoesters I2, I3 and I4-I6 to give five- and six-m...
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| Format: | Article |
| Language: | English |
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MDPI AG
2007-03-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/12/3/439/ |
| _version_ | 1828496240578396160 |
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| author | Aicha Derdour Jack Hamelin Fatima-Zohra Zradni |
| author_facet | Aicha Derdour Jack Hamelin Fatima-Zohra Zradni |
| author_sort | Aicha Derdour |
| collection | DOAJ |
| description | We have previously reported a new synthesis of amides from esters and amines under microwave irradiation, offering much higher yields than those achieved with conventional heating [1]. We have now extended these studies to the ring closure of neat iminoesters I2, I3 and I4-I6 to give five- and six-membered ring lactams L5, L6 and larger lactams L7-L9 (where I means imine and L means lactam), respectively, under both classical heating conditions and microwave irradiation. |
| first_indexed | 2024-12-11T12:26:19Z |
| format | Article |
| id | doaj.art-16a00bade1ec41b49d437db289251b8c |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T12:26:19Z |
| publishDate | 2007-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-16a00bade1ec41b49d437db289251b8c2022-12-22T01:07:22ZengMDPI AGMolecules1420-30492007-03-0112343945410.3390/12030439Solventless Lactam Synthesis by Intramolecular Cyclizations of α-Iminoester Derivatives under Microwave IrradiationAicha DerdourJack HamelinFatima-Zohra ZradniWe have previously reported a new synthesis of amides from esters and amines under microwave irradiation, offering much higher yields than those achieved with conventional heating [1]. We have now extended these studies to the ring closure of neat iminoesters I2, I3 and I4-I6 to give five- and six-membered ring lactams L5, L6 and larger lactams L7-L9 (where I means imine and L means lactam), respectively, under both classical heating conditions and microwave irradiation.http://www.mdpi.com/1420-3049/12/3/439/Medium-sized ring lactamsimine alkylationSchiff basesmicrowave irradiation |
| spellingShingle | Aicha Derdour Jack Hamelin Fatima-Zohra Zradni Solventless Lactam Synthesis by Intramolecular Cyclizations of α-Iminoester Derivatives under Microwave Irradiation Molecules Medium-sized ring lactams imine alkylation Schiff bases microwave irradiation |
| title | Solventless Lactam Synthesis by Intramolecular Cyclizations of α-Iminoester Derivatives under Microwave Irradiation |
| title_full | Solventless Lactam Synthesis by Intramolecular Cyclizations of α-Iminoester Derivatives under Microwave Irradiation |
| title_fullStr | Solventless Lactam Synthesis by Intramolecular Cyclizations of α-Iminoester Derivatives under Microwave Irradiation |
| title_full_unstemmed | Solventless Lactam Synthesis by Intramolecular Cyclizations of α-Iminoester Derivatives under Microwave Irradiation |
| title_short | Solventless Lactam Synthesis by Intramolecular Cyclizations of α-Iminoester Derivatives under Microwave Irradiation |
| title_sort | solventless lactam synthesis by intramolecular cyclizations of α iminoester derivatives under microwave irradiation |
| topic | Medium-sized ring lactams imine alkylation Schiff bases microwave irradiation |
| url | http://www.mdpi.com/1420-3049/12/3/439/ |
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