Role of lysophosphatidic acid receptor LPA<sub>2 </sub>in the development of allergic airway inflammation in a murine model of asthma

Role of lysophosphatidic acid receptor LPA<sub>2 </sub>in the development of allergic airway inflammation in a murine model of asthma

<p>Abstract</p> <p>Background</p> <p>Lysophosphatidic acid (LPA) plays a critical role in airway inflammation through G protein-coupled LPA receptors (LPA<sub>1-3</sub>). We have demonstrated that LPA induced cytokine and lipid mediator release in human bron...

Full description

Bibliographic Details
Main Authors:	Chun Jerold, Evgeny Berdyshev, Pendyala Srikanth, He Donghong, Tong Jiankun, Zhao Yutong, Sperling Anne I, Natarajan Viswanathan
Format:	Article
Language:	English
Published:	BMC 2009-11-01
Series:	Respiratory Research
Online Access:	http://respiratory-research.com/content/10/1/114

Similar Items

Phosphorylation and Internalization of Lysophosphatidic Acid Receptors LPA1, LPA2, and LPA3.
by: Rocío Alcántara-Hernández, et al.
Published: (2015-01-01)

Lysophosphatidic Acid Receptor 5 (LPA<sub>5</sub>) Knockout Ameliorates the Neuroinflammatory Response In Vivo and Modifies the Inflammatory and Metabolic Landscape of Primary Microglia In Vitro
by: Lisha Joshi, et al.
Published: (2022-03-01)

Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain
by: Chun Jerold, et al.
Published: (2008-02-01)

Lysophosphatidic acid (LPA)-antibody (504B3) engagement detected by interferometry identifies off-target binding
by: Manisha Ray, et al.
Published: (2021-04-01)

Dual Role of Lysophosphatidic Acid Receptor 2 (LPA2) in Amyotrophic Lateral Sclerosis
by: Maria Puigdomenech-Poch, et al.
Published: (2021-03-01)

Lysophosphatidic acid, LPA: a bad boy becomes good
by: Budnik Lygia T
Published: (2003-04-01)

MAPK signaling determines lysophosphatidic acid (LPA)-induced inflammation in microglia
by: Ioanna Plastira, et al.
Published: (2020-04-01)

Lysophosphatidic Acid Signaling in Cancer Cells: What Makes LPA So Special?
by: Pravita Balijepalli, et al.
Published: (2021-08-01)

Modulation of lysophosphatidic acid (LPA) receptor activity: the key to successful neural regeneration?
by: Isabel Gross, et al.
Published: (2020-01-01)

Suppressing postcollection lysophosphatidic acid metabolism improves the precision of plasma LPA quantification
by: Kuniyuki Kano, et al.
Published: (2021-01-01)

Lysophosphatidic Acid Induces Apoptosis of PC12 Cells Through LPA1 Receptor/LPA2 Receptor/MAPK Signaling Pathway
by: Jie Zhang, et al.
Published: (2020-02-01)

Lysophosphatidic Acid Inhibits Simvastatin-Induced Myocytoxicity by Activating LPA Receptor/PKC Pathway
by: Kyung-Jong Won, et al.
Published: (2020-03-01)

Lysophosphatidic acid (LPA) 18:1 transcriptional regulation of primary human gingival fibroblasts
by: D. Roselyn Cerutis, et al.
Published: (2014-12-01)

A novel role of lysophosphatidic acid (LPA) in human myeloma resistance to proteasome inhibitors
by: Pan Su, et al.
Published: (2022-05-01)

Loss of spinal substance P pain transmission under the condition of LPA<sub>1 </sub>receptor-mediated neuropathic pain
by: Chun Jerold, et al.
Published: (2006-08-01)

Involvement of LPA<sub>1 </sub>receptor signaling in the reorganization of spinal input through Abeta-fibers in mice with partial sciatic nerve injury
by: Chun Jerold, et al.
Published: (2008-10-01)

Lysophosphatidic acid LPA1 and LPA3 receptors play roles in the maintenance of late tissue plasminogen activator-induced central poststroke pain in mice
by: Hiroshi Ueda, et al.
Published: (2019-01-01)

Lysophospholipid receptors LPA1&ndash;3 are not required for the inhibitory effects of LPA on mouse retinal growth cones
by: Eric Birgbauer, et al.
Published: (2010-02-01)

Altered cleavage plane orientation with increased genomic aneuploidy produced by receptor-mediated lysophosphatidic acid (LPA) signaling in mouse cerebral cortical neural progenitor cells
by: Whitney S. McDonald, et al.
Published: (2020-12-01)

The LPA<sub>3</sub> Receptor: Regulation and Activation of Signaling Pathways
by: Karina Helivier Solís, et al.
Published: (2021-06-01)

Efficacy Comparison of LPA<sub>2</sub> Antagonist H2L5186303 and Agonist GRI977143 on Ovalbumin-Induced Allergic Asthma in BALB/c Mice
by: Ye-Ji Lee, et al.
Published: (2022-08-01)

Compensatory Upregulation of LPA<sub>2</sub> and Activation of the PI3K-Akt Pathway Prevent LPA<sub>5</sub>-Dependent Loss of Intestinal Epithelial Cells in Intestinal Organoids
by: Zhongxing Liang, et al.
Published: (2022-07-01)

Autotaxin and lysophosphatidic acid<sub>1 </sub>receptor-mediated demyelination of dorsal root fibers by sciatic nerve injury and intrathecal lysophosphatidylcholine
by: Aoki Junken, et al.
Published: (2010-11-01)

LPA receptor signaling: pharmacology, physiology, and pathophysiology
by: Yun C. Yung, et al.
Published: (2014-07-01)

Lysophosphatidic Acid Is Associated With Cardiac Dysfunction and Hypertrophy by Suppressing Autophagy via the LPA3/AKT/mTOR Pathway
by: Jinjing Yang, et al.
Published: (2018-09-01)

Transgenic Expression of Human Lysophosphatidic Acid Receptor LPA2 in Mouse Intestinal Epithelial Cells Induces Intestinal Dysplasia.
by: Michihiro Yoshida, et al.
Published: (2016-01-01)

Lysophosphatidic Acid Inhibits Insulin Signaling in Primary Rat Hepatocytes via the LPA3 Receptor Subtype and is Increased in Obesity
by: Susann Fayyaz, et al.
Published: (2017-09-01)

LPA5 is abundantly expressed by human mast cells and important for lysophosphatidic acid induced MIP-1β release.
by: Anders Lundequist, et al.
Published: (2011-03-01)

Attenuation of allergic airway inflammation and hyperresponsiveness in a murine model of asthma by silver nanoparticles
by: Hee Sun Park, et al.
Published: (2010-07-01)

Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain
by: Aoki Junken, et al.
Published: (2009-11-01)

Inhalation exposure to nanosized and fine TiO<sub>2 </sub>particles inhibits features of allergic asthma in a murine model
by: Wolff Henrik, et al.
Published: (2010-11-01)

Lysophosphatidic acid receptor 1 (LPA1) plays critical roles in microglial activation and brain damage after transient focal cerebral ischemia
by: Bhakta Prasad Gaire, et al.
Published: (2019-08-01)

Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype
by: I. Plastira, et al.
Published: (2017-12-01)

The effects of tiger milk mushroom (lignosus rhinocerotis) on airway inflammation in murine models of allergic asthma
by: Muhamad, Siti Aminah
Published: (2020)

Biosignature for airway inflammation in a house dust mite-challenged murine model of allergic asthma
by: Hadeesha Piyadasa, et al.
Published: (2016-02-01)

Crude extracts of Caenorhabditis elegans suppress airway inflammation in a murine model of allergic asthma.
by: Sung Eun Kim, et al.
Published: (2012-01-01)

Pharmacological OGG1 inhibition decreases murine allergic airway inflammation
by: Lloyd Tanner, et al.
Published: (2022-10-01)

LPA<sub>1</sub> Receptor Promotes Progesterone Receptor Phosphorylation through PKCα in Human Glioblastoma Cells
by: Silvia Anahi Valdés-Rives, et al.
Published: (2021-04-01)

BMS-986020, a Specific LPA<sub>1</sub> Antagonist, Provides Neuroprotection against Ischemic Stroke in Mice
by: Bhakta Prasad Gaire, et al.
Published: (2020-11-01)

Lysophosphatidic Acid Is Associated with Atherosclerotic Plaque Instability by Regulating NF-κB Dependent Matrix Metalloproteinase-9 Expression via LPA2 in Macrophages
by: Xi Chen, et al.
Published: (2017-04-01)