The Combined Diffusion and Adsorption Concept for Prediction of Nanoparticles Transport through Dermal Layers Based on Experiments in Membranes
The non-invasive introduction of active substances into the human body is a top challenge for researchers in medicine, pharmacology, and cosmetology. Development of nanotechnology and possibilities of creating more and more complex drug carriers on a nanoscale give a more realistic prospect of meeti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/12/6419 |
| _version_ | 1797486612354957312 |
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| author | Mariola M. Błaszczyk Jerzy Sęk Łukasz Przybysz |
| author_facet | Mariola M. Błaszczyk Jerzy Sęk Łukasz Przybysz |
| author_sort | Mariola M. Błaszczyk |
| collection | DOAJ |
| description | The non-invasive introduction of active substances into the human body is a top challenge for researchers in medicine, pharmacology, and cosmetology. Development of nanotechnology and possibilities of creating more and more complex drug carriers on a nanoscale give a more realistic prospect of meeting this challenge. However, in the absence of sufficient knowledge of the mechanisms of such systems’ transport through the human skin structure, it is necessary to look deeper into these issues. There are several models describing nanoparticles transport through the skin, but they are mainly based on diffusion process analysis. In this work, a model was proposed to predict nanoparticles transport through the skin, based on the combined diffusion and adsorption concept. This approach was based on experimental studies of silver and copper nanoparticles’ diffusion process through different filtration membrane layers. Dependence of the degree of adsorption on the surface parameter was described using modified Langmuir equation. Then, these considerations were related to the structure of the stratum corneum, which made it possible to predict the changes in the mass of penetrating nanoparticles as a function of transport path length. A discussion of the presented model, depending on such parameters as nanoparticle size, skin cell thickness, or viscosity of the “intercellular cement”, was also performed. |
| first_indexed | 2024-03-09T23:35:43Z |
| format | Article |
| id | doaj.art-16a098fdd11946b19d984d134a4b26bf |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:35:43Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-16a098fdd11946b19d984d134a4b26bf2023-11-23T17:00:25ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-06-012312641910.3390/ijms23126419The Combined Diffusion and Adsorption Concept for Prediction of Nanoparticles Transport through Dermal Layers Based on Experiments in MembranesMariola M. Błaszczyk0Jerzy Sęk1Łukasz Przybysz2Department of Chemical Engineering, Faculty of Process and Environmental Engineering, Lodz University of Technology, 213 Wolczanska St., 90-924 Lodz, PolandDepartment of Chemical Engineering, Faculty of Process and Environmental Engineering, Lodz University of Technology, 213 Wolczanska St., 90-924 Lodz, PolandDepartment of Chemical Engineering, Faculty of Process and Environmental Engineering, Lodz University of Technology, 213 Wolczanska St., 90-924 Lodz, PolandThe non-invasive introduction of active substances into the human body is a top challenge for researchers in medicine, pharmacology, and cosmetology. Development of nanotechnology and possibilities of creating more and more complex drug carriers on a nanoscale give a more realistic prospect of meeting this challenge. However, in the absence of sufficient knowledge of the mechanisms of such systems’ transport through the human skin structure, it is necessary to look deeper into these issues. There are several models describing nanoparticles transport through the skin, but they are mainly based on diffusion process analysis. In this work, a model was proposed to predict nanoparticles transport through the skin, based on the combined diffusion and adsorption concept. This approach was based on experimental studies of silver and copper nanoparticles’ diffusion process through different filtration membrane layers. Dependence of the degree of adsorption on the surface parameter was described using modified Langmuir equation. Then, these considerations were related to the structure of the stratum corneum, which made it possible to predict the changes in the mass of penetrating nanoparticles as a function of transport path length. A discussion of the presented model, depending on such parameters as nanoparticle size, skin cell thickness, or viscosity of the “intercellular cement”, was also performed.https://www.mdpi.com/1422-0067/23/12/6419nanoparticlesdrug carriersdrug deliverymicrofluidicsnanoparticle diffusionnanoparticle adsorption |
| spellingShingle | Mariola M. Błaszczyk Jerzy Sęk Łukasz Przybysz The Combined Diffusion and Adsorption Concept for Prediction of Nanoparticles Transport through Dermal Layers Based on Experiments in Membranes International Journal of Molecular Sciences nanoparticles drug carriers drug delivery microfluidics nanoparticle diffusion nanoparticle adsorption |
| title | The Combined Diffusion and Adsorption Concept for Prediction of Nanoparticles Transport through Dermal Layers Based on Experiments in Membranes |
| title_full | The Combined Diffusion and Adsorption Concept for Prediction of Nanoparticles Transport through Dermal Layers Based on Experiments in Membranes |
| title_fullStr | The Combined Diffusion and Adsorption Concept for Prediction of Nanoparticles Transport through Dermal Layers Based on Experiments in Membranes |
| title_full_unstemmed | The Combined Diffusion and Adsorption Concept for Prediction of Nanoparticles Transport through Dermal Layers Based on Experiments in Membranes |
| title_short | The Combined Diffusion and Adsorption Concept for Prediction of Nanoparticles Transport through Dermal Layers Based on Experiments in Membranes |
| title_sort | combined diffusion and adsorption concept for prediction of nanoparticles transport through dermal layers based on experiments in membranes |
| topic | nanoparticles drug carriers drug delivery microfluidics nanoparticle diffusion nanoparticle adsorption |
| url | https://www.mdpi.com/1422-0067/23/12/6419 |
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