Effects of oral stimulation with capsaicin on salivary secretion and neural activities in the autonomic system and the brain
Background/purpose: Although it has been reported that capsaicin ingestion has effects of protecting stomach mucosa and promoting energy consumption, physiological responses to oral stimulation with capsaicin has not been elucidated. Therefore, we investigated the effect of oral capsaicin stimulatio...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-06-01
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| Series: | Journal of Dental Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1991790217301320 |
| _version_ | 1818176631384047616 |
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| author | Yoko Kono Ayako Kubota Masato Taira Narumi Katsuyama Kumiko Sugimoto |
| author_facet | Yoko Kono Ayako Kubota Masato Taira Narumi Katsuyama Kumiko Sugimoto |
| author_sort | Yoko Kono |
| collection | DOAJ |
| description | Background/purpose: Although it has been reported that capsaicin ingestion has effects of protecting stomach mucosa and promoting energy consumption, physiological responses to oral stimulation with capsaicin has not been elucidated. Therefore, we investigated the effect of oral capsaicin stimulation on oral health and mental conditions by measuring changes in salivation, autonomic nervous activity and electroencephalogram (EEG).
Materials and methods: Eighteen healthy adults participated in this study. The stimulus concentrations of capsaicin and five basic taste solutions were determined based on the measured threshold of each stimulus in each subject. The weight of secreted saliva and the changes in concentrations of salivary secretory immunoglobulin A (SIgA) induced by capsaicin and taste stimuli were measured. Salivary α-amylase activity and heart rate variability (HRV) were measured as indicators of autonomic nervous activity. From EEG, psychological condition was analyzed by measuring the powers of theta, alpha, and beta bands.
Results: The salivary secretion rate was significantly increased by stimulation with capsaicin, NaCl, and citric acid compared with deionized water, and capsaicin demonstrated the most potent effect among tested stimuli. The secreted amount of SIgA per minute was elevated by capsaicin stimulation. Salivary α-amylase activity and HRV analysis demonstrated an elevation of sympathetic nervous activity induced by capsaicin. EEG analysis showed a significant increase in beta band power.
Conclusion: These results suggest that oral stimulation with capsaicin may be effective in improving oral conditions by increasing salivary flow and SIgA secretion, and in enhancing physical and mental conditions as indicated by sympathetic nerve and EEG changes. |
| first_indexed | 2024-12-11T20:19:16Z |
| format | Article |
| id | doaj.art-16a14ac4191745c183f8d4755e1dc269 |
| institution | Directory Open Access Journal |
| issn | 1991-7902 |
| language | English |
| last_indexed | 2024-12-11T20:19:16Z |
| publishDate | 2018-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Dental Sciences |
| spelling | doaj.art-16a14ac4191745c183f8d4755e1dc2692022-12-22T00:52:06ZengElsevierJournal of Dental Sciences1991-79022018-06-0113211612310.1016/j.jds.2017.08.007Effects of oral stimulation with capsaicin on salivary secretion and neural activities in the autonomic system and the brainYoko Kono0Ayako Kubota1Masato Taira2Narumi Katsuyama3Kumiko Sugimoto4Department of Cognitive Neurobiology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, JapanDepartment of Behavioral Dentistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, JapanDepartment of Cognitive Neurobiology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, JapanDepartment of Cognitive Neurobiology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, JapanCourse for Oral Health Engineering, School of Oral Health Care Sciences, Faculty of Dentistry, Tokyo Medical and Dental University, Tokyo, JapanBackground/purpose: Although it has been reported that capsaicin ingestion has effects of protecting stomach mucosa and promoting energy consumption, physiological responses to oral stimulation with capsaicin has not been elucidated. Therefore, we investigated the effect of oral capsaicin stimulation on oral health and mental conditions by measuring changes in salivation, autonomic nervous activity and electroencephalogram (EEG). Materials and methods: Eighteen healthy adults participated in this study. The stimulus concentrations of capsaicin and five basic taste solutions were determined based on the measured threshold of each stimulus in each subject. The weight of secreted saliva and the changes in concentrations of salivary secretory immunoglobulin A (SIgA) induced by capsaicin and taste stimuli were measured. Salivary α-amylase activity and heart rate variability (HRV) were measured as indicators of autonomic nervous activity. From EEG, psychological condition was analyzed by measuring the powers of theta, alpha, and beta bands. Results: The salivary secretion rate was significantly increased by stimulation with capsaicin, NaCl, and citric acid compared with deionized water, and capsaicin demonstrated the most potent effect among tested stimuli. The secreted amount of SIgA per minute was elevated by capsaicin stimulation. Salivary α-amylase activity and HRV analysis demonstrated an elevation of sympathetic nervous activity induced by capsaicin. EEG analysis showed a significant increase in beta band power. Conclusion: These results suggest that oral stimulation with capsaicin may be effective in improving oral conditions by increasing salivary flow and SIgA secretion, and in enhancing physical and mental conditions as indicated by sympathetic nerve and EEG changes.http://www.sciencedirect.com/science/article/pii/S1991790217301320autonomic nervous activitycapsaicinelectroencephalographypungent tastesalivary componentsalivary secretion |
| spellingShingle | Yoko Kono Ayako Kubota Masato Taira Narumi Katsuyama Kumiko Sugimoto Effects of oral stimulation with capsaicin on salivary secretion and neural activities in the autonomic system and the brain Journal of Dental Sciences autonomic nervous activity capsaicin electroencephalography pungent taste salivary component salivary secretion |
| title | Effects of oral stimulation with capsaicin on salivary secretion and neural activities in the autonomic system and the brain |
| title_full | Effects of oral stimulation with capsaicin on salivary secretion and neural activities in the autonomic system and the brain |
| title_fullStr | Effects of oral stimulation with capsaicin on salivary secretion and neural activities in the autonomic system and the brain |
| title_full_unstemmed | Effects of oral stimulation with capsaicin on salivary secretion and neural activities in the autonomic system and the brain |
| title_short | Effects of oral stimulation with capsaicin on salivary secretion and neural activities in the autonomic system and the brain |
| title_sort | effects of oral stimulation with capsaicin on salivary secretion and neural activities in the autonomic system and the brain |
| topic | autonomic nervous activity capsaicin electroencephalography pungent taste salivary component salivary secretion |
| url | http://www.sciencedirect.com/science/article/pii/S1991790217301320 |
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