Modifiable Risk Factor Possession Patterns of Dementia in Elderly with MCI: A 4-Year Repeated Measures Study
This study clarified the patterns of possessing modifiable risk factors of dementia that can be corrected by the elderly who were primarily determined to have mild cognitive impairment (MCI), and then determined the relationship between retention patterns and outcomes from MCI through a 4-year follo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/4/1076 |
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| author | Osamu Katayama Sangyoon Lee Seongryu Bae Keitaro Makino Yohei Shinkai Ippei Chiba Kenji Harada Hiroyuki Shimada |
| author_facet | Osamu Katayama Sangyoon Lee Seongryu Bae Keitaro Makino Yohei Shinkai Ippei Chiba Kenji Harada Hiroyuki Shimada |
| author_sort | Osamu Katayama |
| collection | DOAJ |
| description | This study clarified the patterns of possessing modifiable risk factors of dementia that can be corrected by the elderly who were primarily determined to have mild cognitive impairment (MCI), and then determined the relationship between retention patterns and outcomes from MCI through a 4-year follow-up study. The participants were 789 community-dwelling elders who were ≥65 years old with MCI at baseline. After 4 years, participants were classified into reverters and nonreverters, according to their cognitive function. Repeated measures analysis was performed after imputing missing values due to dropout. Nine modifiable risk factors at baseline were classified by latent class analysis. Subsequently, we performed binomial logistic regression analysis. The reversion rate of 789 participants was 30.9%. The possession patterns of modifiable risk factors among the elderly with MCI were classified into five patterns: low risk, psychosocial, health behavior, educational, and smoking factors. According to logistic regression analysis, the low risk factors class was more likely to recover from MCI to normal cognitive than the other classes (<i>p</i> < 0.05). These results may provide useful information for designing interventions to prevent cognitive decline and dementia in individuals with MCI. |
| first_indexed | 2024-03-10T20:32:39Z |
| format | Article |
| id | doaj.art-16a26d0e7ad342e4a44517ce2ed734fc |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T20:32:39Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-16a26d0e7ad342e4a44517ce2ed734fc2023-11-19T21:13:42ZengMDPI AGJournal of Clinical Medicine2077-03832020-04-0194107610.3390/jcm9041076Modifiable Risk Factor Possession Patterns of Dementia in Elderly with MCI: A 4-Year Repeated Measures StudyOsamu Katayama0Sangyoon Lee1Seongryu Bae2Keitaro Makino3Yohei Shinkai4Ippei Chiba5Kenji Harada6Hiroyuki Shimada7Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu City 474-8511, Aichi, JapanDepartment of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu City 474-8511, Aichi, JapanDepartment of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu City 474-8511, Aichi, JapanDepartment of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu City 474-8511, Aichi, JapanDepartment of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu City 474-8511, Aichi, JapanDepartment of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu City 474-8511, Aichi, JapanDepartment of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu City 474-8511, Aichi, JapanDepartment of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu City 474-8511, Aichi, JapanThis study clarified the patterns of possessing modifiable risk factors of dementia that can be corrected by the elderly who were primarily determined to have mild cognitive impairment (MCI), and then determined the relationship between retention patterns and outcomes from MCI through a 4-year follow-up study. The participants were 789 community-dwelling elders who were ≥65 years old with MCI at baseline. After 4 years, participants were classified into reverters and nonreverters, according to their cognitive function. Repeated measures analysis was performed after imputing missing values due to dropout. Nine modifiable risk factors at baseline were classified by latent class analysis. Subsequently, we performed binomial logistic regression analysis. The reversion rate of 789 participants was 30.9%. The possession patterns of modifiable risk factors among the elderly with MCI were classified into five patterns: low risk, psychosocial, health behavior, educational, and smoking factors. According to logistic regression analysis, the low risk factors class was more likely to recover from MCI to normal cognitive than the other classes (<i>p</i> < 0.05). These results may provide useful information for designing interventions to prevent cognitive decline and dementia in individuals with MCI.https://www.mdpi.com/2077-0383/9/4/1076mild cognitive impairmentlatent class analysismodifiable risk factorpsychosocialhealth behavioreducational |
| spellingShingle | Osamu Katayama Sangyoon Lee Seongryu Bae Keitaro Makino Yohei Shinkai Ippei Chiba Kenji Harada Hiroyuki Shimada Modifiable Risk Factor Possession Patterns of Dementia in Elderly with MCI: A 4-Year Repeated Measures Study Journal of Clinical Medicine mild cognitive impairment latent class analysis modifiable risk factor psychosocial health behavior educational |
| title | Modifiable Risk Factor Possession Patterns of Dementia in Elderly with MCI: A 4-Year Repeated Measures Study |
| title_full | Modifiable Risk Factor Possession Patterns of Dementia in Elderly with MCI: A 4-Year Repeated Measures Study |
| title_fullStr | Modifiable Risk Factor Possession Patterns of Dementia in Elderly with MCI: A 4-Year Repeated Measures Study |
| title_full_unstemmed | Modifiable Risk Factor Possession Patterns of Dementia in Elderly with MCI: A 4-Year Repeated Measures Study |
| title_short | Modifiable Risk Factor Possession Patterns of Dementia in Elderly with MCI: A 4-Year Repeated Measures Study |
| title_sort | modifiable risk factor possession patterns of dementia in elderly with mci a 4 year repeated measures study |
| topic | mild cognitive impairment latent class analysis modifiable risk factor psychosocial health behavior educational |
| url | https://www.mdpi.com/2077-0383/9/4/1076 |
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