Clinical value of detection on ser um monocyte chemotactant protein-1 and vascular endothelial cadher in levels in patients with acute cerebral infarction
Objective: To study the correlation of serum monocyte chemotactant protein-1 (MCP-1) and vascular endothelia cadherin (VE-cadherin) levels in patients with acute cerebral infarction, and nerve injury molecules, interleukins and matrix metalloproteinases. Methods: A total of 86 patients with acute...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-11-01
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| Series: | Journal of Acute Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2221618916301603 |
| _version_ | 1811337374923227136 |
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| author | Xia Zhou Cheng Zhang |
| author_facet | Xia Zhou Cheng Zhang |
| author_sort | Xia Zhou |
| collection | DOAJ |
| description | Objective: To study the correlation of serum monocyte chemotactant protein-1 (MCP-1)
and vascular endothelia cadherin (VE-cadherin) levels in patients with acute cerebral
infarction, and nerve injury molecules, interleukins and matrix metalloproteinases.
Methods: A total of 86 patients with acute cerebral infarction treated in our hospital from
April 2012 to October 2015 were selected as the observation group and 50 healthy
subjects in the same period treated in our hospital were selected as the control group. The
serums were collected and the contents of MCP-1, VE-cadherin, heart-type fatty acid
binding protein (H-FABP), S100 calcium binding protein B (S100B), neuron-specific
enolase (NSE), interleukin-lb (IL-1b), IL-6, IL-17, IL-18, matrix metalloproteinase-2
(MMP2), MMP3 and MMP9 were measured.
Results: The serum contents of MCP-1, VE-cadherin, H-FABP, S100B, NSE, IL-1b, IL-
6, IL-17, IL-18, MMP2, MMP3 and MMP9 in observation group were significantly
higher than those of control group. Carotid artery plaque formation and unstable plaque
properties will increase the serum contents of MCP-1, VE-cadherin, H-FABP, S100B,
NSE, IL-1b, IL-6, IL-17, IL-18, MMP2, MMP3 and MMP9 in patients with cerebral
infarction. The serum levels of MCP-1, VE-cadherin and the contents of H-FABP,
S100B, NSE, IL-1b, IL-6, IL-17, IL-18, MMP2, MMP3 and MMP9 were positively
correlated.
Conclusions: The serum levels of VE-cadherin and MCP-1 were significantly increased
in patients with acute cerebral infarction. MCP-1 and VE-cadherin can increase the
secretion of interleukins and matrix metalloproteinases, which can result in the carotid
artery plaque formation, unstable plaque properties and the injury of nerve function. |
| first_indexed | 2024-04-13T17:53:58Z |
| format | Article |
| id | doaj.art-16a4d9c6af8547bfb4a793ff77ede65f |
| institution | Directory Open Access Journal |
| issn | 2221-6189 |
| language | English |
| last_indexed | 2024-04-13T17:53:58Z |
| publishDate | 2016-11-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Acute Disease |
| spelling | doaj.art-16a4d9c6af8547bfb4a793ff77ede65f2022-12-22T02:36:35ZengWolters Kluwer Medknow PublicationsJournal of Acute Disease2221-61892016-11-015650250610.1016/j.joad.2016.08.022Clinical value of detection on ser um monocyte chemotactant protein-1 and vascular endothelial cadher in levels in patients with acute cerebral infarctionXia Zhou0Cheng Zhang1Department of Neurology, the Third People's Hospital, Zigong 643020, Sichuan Province, ChinaDepartment of Neurosurgery, the Third People's Hospital, Zigong 643020, Sichuan Province, ChinaObjective: To study the correlation of serum monocyte chemotactant protein-1 (MCP-1) and vascular endothelia cadherin (VE-cadherin) levels in patients with acute cerebral infarction, and nerve injury molecules, interleukins and matrix metalloproteinases. Methods: A total of 86 patients with acute cerebral infarction treated in our hospital from April 2012 to October 2015 were selected as the observation group and 50 healthy subjects in the same period treated in our hospital were selected as the control group. The serums were collected and the contents of MCP-1, VE-cadherin, heart-type fatty acid binding protein (H-FABP), S100 calcium binding protein B (S100B), neuron-specific enolase (NSE), interleukin-lb (IL-1b), IL-6, IL-17, IL-18, matrix metalloproteinase-2 (MMP2), MMP3 and MMP9 were measured. Results: The serum contents of MCP-1, VE-cadherin, H-FABP, S100B, NSE, IL-1b, IL- 6, IL-17, IL-18, MMP2, MMP3 and MMP9 in observation group were significantly higher than those of control group. Carotid artery plaque formation and unstable plaque properties will increase the serum contents of MCP-1, VE-cadherin, H-FABP, S100B, NSE, IL-1b, IL-6, IL-17, IL-18, MMP2, MMP3 and MMP9 in patients with cerebral infarction. The serum levels of MCP-1, VE-cadherin and the contents of H-FABP, S100B, NSE, IL-1b, IL-6, IL-17, IL-18, MMP2, MMP3 and MMP9 were positively correlated. Conclusions: The serum levels of VE-cadherin and MCP-1 were significantly increased in patients with acute cerebral infarction. MCP-1 and VE-cadherin can increase the secretion of interleukins and matrix metalloproteinases, which can result in the carotid artery plaque formation, unstable plaque properties and the injury of nerve function.http://www.sciencedirect.com/science/article/pii/S2221618916301603Acute cerebral infarctionMonocyte chemotactant protein-1Vascular endothelial cadherinInterleukinsMatrix metalloproteinases |
| spellingShingle | Xia Zhou Cheng Zhang Clinical value of detection on ser um monocyte chemotactant protein-1 and vascular endothelial cadher in levels in patients with acute cerebral infarction Journal of Acute Disease Acute cerebral infarction Monocyte chemotactant protein-1 Vascular endothelial cadherin Interleukins Matrix metalloproteinases |
| title | Clinical value of detection on ser um monocyte chemotactant protein-1 and vascular endothelial cadher in levels in patients with acute cerebral infarction |
| title_full | Clinical value of detection on ser um monocyte chemotactant protein-1 and vascular endothelial cadher in levels in patients with acute cerebral infarction |
| title_fullStr | Clinical value of detection on ser um monocyte chemotactant protein-1 and vascular endothelial cadher in levels in patients with acute cerebral infarction |
| title_full_unstemmed | Clinical value of detection on ser um monocyte chemotactant protein-1 and vascular endothelial cadher in levels in patients with acute cerebral infarction |
| title_short | Clinical value of detection on ser um monocyte chemotactant protein-1 and vascular endothelial cadher in levels in patients with acute cerebral infarction |
| title_sort | clinical value of detection on ser um monocyte chemotactant protein 1 and vascular endothelial cadher in levels in patients with acute cerebral infarction |
| topic | Acute cerebral infarction Monocyte chemotactant protein-1 Vascular endothelial cadherin Interleukins Matrix metalloproteinases |
| url | http://www.sciencedirect.com/science/article/pii/S2221618916301603 |
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