Glucocorticoid-Induced Osteoporosis: The Potential Role of Romosozumab
Glucocorticoid (GC)-induced osteoporosis (GIOP) is a major problem in patients with rheumatic diseases. The deleterious effect of GC on bone turnover is rapid and dose-dependent, with a predilection on the trabecular bone, resulting in vertebral fractures. Early recognition and prompt treatment of G...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
World Scientific Publishing
2020-12-01
|
| Series: | Journal of Clinical Rheumatology and Immunology |
| Subjects: | |
| Online Access: | http://www.worldscientific.com/doi/epdf/10.1142/S2661341720300074 |
| _version_ | 1828918089928933376 |
|---|---|
| author | Jacqueline So Chi Chiu Mok |
| author_facet | Jacqueline So Chi Chiu Mok |
| author_sort | Jacqueline So |
| collection | DOAJ |
| description | Glucocorticoid (GC)-induced osteoporosis (GIOP) is a major problem in patients with rheumatic diseases. The deleterious effect of GC on bone turnover is rapid and dose-dependent, with a predilection on the trabecular bone, resulting in vertebral fractures. Early recognition and prompt treatment of GIOP helps prevent bone loss and reduce fractures. There are pitfalls in current assessment tools for GIOP by dual-energy X-ray absorptiometry (DXA) and fracture risk assessment tool (FRAX) estimation formula. In this review, we evaluate different assessment methods for GIOP and summarize current therapies of GIOP, including the antiresorptive and anabolic agents. The potential role of newer anti-osteoporosis agent romosozumab, an anti-sclerostin monoclonal antibody, is also discussed. |
| first_indexed | 2024-12-13T21:04:27Z |
| format | Article |
| id | doaj.art-16a56df878824f8cad0b7a2993b62d0e |
| institution | Directory Open Access Journal |
| issn | 2661-3417 2661-3425 |
| language | English |
| last_indexed | 2024-12-13T21:04:27Z |
| publishDate | 2020-12-01 |
| publisher | World Scientific Publishing |
| record_format | Article |
| series | Journal of Clinical Rheumatology and Immunology |
| spelling | doaj.art-16a56df878824f8cad0b7a2993b62d0e2022-12-21T23:31:31ZengWorld Scientific PublishingJournal of Clinical Rheumatology and Immunology2661-34172661-34252020-12-01202717910.1142/S266134172030007410.1142/S2661341720300074Glucocorticoid-Induced Osteoporosis: The Potential Role of RomosozumabJacqueline So0Chi Chiu Mok1Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong SAR, ChinaDepartment of Medicine and Geriatrics, Tuen Mun Hospital, Hong Kong SAR, ChinaGlucocorticoid (GC)-induced osteoporosis (GIOP) is a major problem in patients with rheumatic diseases. The deleterious effect of GC on bone turnover is rapid and dose-dependent, with a predilection on the trabecular bone, resulting in vertebral fractures. Early recognition and prompt treatment of GIOP helps prevent bone loss and reduce fractures. There are pitfalls in current assessment tools for GIOP by dual-energy X-ray absorptiometry (DXA) and fracture risk assessment tool (FRAX) estimation formula. In this review, we evaluate different assessment methods for GIOP and summarize current therapies of GIOP, including the antiresorptive and anabolic agents. The potential role of newer anti-osteoporosis agent romosozumab, an anti-sclerostin monoclonal antibody, is also discussed.http://www.worldscientific.com/doi/epdf/10.1142/S2661341720300074glucocorticoid-induced osteoporosisromosozumabdenosumabteriparatidecorticosteroidfracture |
| spellingShingle | Jacqueline So Chi Chiu Mok Glucocorticoid-Induced Osteoporosis: The Potential Role of Romosozumab Journal of Clinical Rheumatology and Immunology glucocorticoid-induced osteoporosis romosozumab denosumab teriparatide corticosteroid fracture |
| title | Glucocorticoid-Induced Osteoporosis: The Potential Role of Romosozumab |
| title_full | Glucocorticoid-Induced Osteoporosis: The Potential Role of Romosozumab |
| title_fullStr | Glucocorticoid-Induced Osteoporosis: The Potential Role of Romosozumab |
| title_full_unstemmed | Glucocorticoid-Induced Osteoporosis: The Potential Role of Romosozumab |
| title_short | Glucocorticoid-Induced Osteoporosis: The Potential Role of Romosozumab |
| title_sort | glucocorticoid induced osteoporosis the potential role of romosozumab |
| topic | glucocorticoid-induced osteoporosis romosozumab denosumab teriparatide corticosteroid fracture |
| url | http://www.worldscientific.com/doi/epdf/10.1142/S2661341720300074 |
| work_keys_str_mv | AT jacquelineso glucocorticoidinducedosteoporosisthepotentialroleofromosozumab AT chichiumok glucocorticoidinducedosteoporosisthepotentialroleofromosozumab |