Dynamic alterations in white blood cell counts and SARS-CoV-2 shedding in saliva: an infection predictor parameter
IntroductionThe recent coronavirus (COVID-19) outbreak posed a global threat and quickly escalated to a pandemic. However, accurate information on potential relationships between SARS-CoV-2 shedding in body fluids, especially saliva, and white blood cell (WBC) count is limited. In the present study...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1208928/full |
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| author | Parisa Shiri Aghbash Parisa Shiri Aghbash Reyhaneh Rasizadeh Reyhaneh Rasizadeh Milad Shirvaliloo Javid Sadri Nahand Hossein Bannazadeh Baghi Hossein Bannazadeh Baghi Hossein Bannazadeh Baghi |
| author_facet | Parisa Shiri Aghbash Parisa Shiri Aghbash Reyhaneh Rasizadeh Reyhaneh Rasizadeh Milad Shirvaliloo Javid Sadri Nahand Hossein Bannazadeh Baghi Hossein Bannazadeh Baghi Hossein Bannazadeh Baghi |
| author_sort | Parisa Shiri Aghbash |
| collection | DOAJ |
| description | IntroductionThe recent coronavirus (COVID-19) outbreak posed a global threat and quickly escalated to a pandemic. However, accurate information on potential relationships between SARS-CoV-2 shedding in body fluids, especially saliva, and white blood cell (WBC) count is limited. In the present study we investigated the potential correlation between alterations in blood cell counts and viral shedding in saliva in a cohort of COVID-19 patients.MethodIn this preliminary clinical research, 24 age-matched COVID-19 patients without comorbidities, 12 (50%) men and 12 (50%) women, were followed up for a period of 5 days to investigate whether changes in the level of viral shedding in saliva might parallel with temporal alterations in WBC count. Viral shedding in saliva was qualitatively measured by performing SARS-CoV-2 rapid antigen tests on patient saliva samples, using SARS-CoV-2 Rapid Antigen Test Kit (Roche, Basel, Switzerland). These patients were classified into two groups with sputum and non-sputum cough. WBCs counts including leukocyte (LYM), neutrophil (NEU), and LYM counts were recorded for each patient on days 1, 3, and 5.ResultsThe results of the present study showed that the levels of WBC, LYM, and NEU as well as erythrocyte sedimentation rate (ESR) increased significantly on the 5th day compared to the first day in both groups with sputum. However, the levels of C-reactive protein (CRP), Neutrophil-to-Lymphocyte Ratio (NLR) and lactate dehydrogenase (LDH) did not show significant changes.ConclusionThis study proves that investigating the change in the number of blood LYMs as well as laboratory parameters such as CRP, LDH, and ESR as biomarkers is an accurate indicator to detect the amount of viral shedding in people with sputum and non-sputum. The results of our study denote that the measured parameters exhibit the intensity of viral shedding in people with sputum. |
| first_indexed | 2024-03-13T05:26:07Z |
| format | Article |
| id | doaj.art-16a574ce7f3e4ea08a55c7df90ca7624 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-13T05:26:07Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-16a574ce7f3e4ea08a55c7df90ca76242023-06-15T05:39:04ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-06-011010.3389/fmed.2023.12089281208928Dynamic alterations in white blood cell counts and SARS-CoV-2 shedding in saliva: an infection predictor parameterParisa Shiri Aghbash0Parisa Shiri Aghbash1Reyhaneh Rasizadeh2Reyhaneh Rasizadeh3Milad Shirvaliloo4Javid Sadri Nahand5Hossein Bannazadeh Baghi6Hossein Bannazadeh Baghi7Hossein Bannazadeh Baghi8Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IranImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IranInfectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, IranInfectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, IranImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IranInfectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, IranIntroductionThe recent coronavirus (COVID-19) outbreak posed a global threat and quickly escalated to a pandemic. However, accurate information on potential relationships between SARS-CoV-2 shedding in body fluids, especially saliva, and white blood cell (WBC) count is limited. In the present study we investigated the potential correlation between alterations in blood cell counts and viral shedding in saliva in a cohort of COVID-19 patients.MethodIn this preliminary clinical research, 24 age-matched COVID-19 patients without comorbidities, 12 (50%) men and 12 (50%) women, were followed up for a period of 5 days to investigate whether changes in the level of viral shedding in saliva might parallel with temporal alterations in WBC count. Viral shedding in saliva was qualitatively measured by performing SARS-CoV-2 rapid antigen tests on patient saliva samples, using SARS-CoV-2 Rapid Antigen Test Kit (Roche, Basel, Switzerland). These patients were classified into two groups with sputum and non-sputum cough. WBCs counts including leukocyte (LYM), neutrophil (NEU), and LYM counts were recorded for each patient on days 1, 3, and 5.ResultsThe results of the present study showed that the levels of WBC, LYM, and NEU as well as erythrocyte sedimentation rate (ESR) increased significantly on the 5th day compared to the first day in both groups with sputum. However, the levels of C-reactive protein (CRP), Neutrophil-to-Lymphocyte Ratio (NLR) and lactate dehydrogenase (LDH) did not show significant changes.ConclusionThis study proves that investigating the change in the number of blood LYMs as well as laboratory parameters such as CRP, LDH, and ESR as biomarkers is an accurate indicator to detect the amount of viral shedding in people with sputum and non-sputum. The results of our study denote that the measured parameters exhibit the intensity of viral shedding in people with sputum.https://www.frontiersin.org/articles/10.3389/fmed.2023.1208928/fullSARS-CoV-2COVID-19laboratory testsbiomarkersblood cell countsputum |
| spellingShingle | Parisa Shiri Aghbash Parisa Shiri Aghbash Reyhaneh Rasizadeh Reyhaneh Rasizadeh Milad Shirvaliloo Javid Sadri Nahand Hossein Bannazadeh Baghi Hossein Bannazadeh Baghi Hossein Bannazadeh Baghi Dynamic alterations in white blood cell counts and SARS-CoV-2 shedding in saliva: an infection predictor parameter Frontiers in Medicine SARS-CoV-2 COVID-19 laboratory tests biomarkers blood cell count sputum |
| title | Dynamic alterations in white blood cell counts and SARS-CoV-2 shedding in saliva: an infection predictor parameter |
| title_full | Dynamic alterations in white blood cell counts and SARS-CoV-2 shedding in saliva: an infection predictor parameter |
| title_fullStr | Dynamic alterations in white blood cell counts and SARS-CoV-2 shedding in saliva: an infection predictor parameter |
| title_full_unstemmed | Dynamic alterations in white blood cell counts and SARS-CoV-2 shedding in saliva: an infection predictor parameter |
| title_short | Dynamic alterations in white blood cell counts and SARS-CoV-2 shedding in saliva: an infection predictor parameter |
| title_sort | dynamic alterations in white blood cell counts and sars cov 2 shedding in saliva an infection predictor parameter |
| topic | SARS-CoV-2 COVID-19 laboratory tests biomarkers blood cell count sputum |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1208928/full |
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