Stem Cell Therapy: A Promising Therapeutic Method for Intracerebral Hemorrhage
Spontaneous intracerebral hemorrhage (ICH) is one type of the most devastating cerebrovascular diseases worldwide, which causes high morbidity and mortality. However, efficient treatment is still lacking. Stem cell therapy has shown good neuroprotective and neurorestorative effect in ICH and is a pr...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2018-12-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.1177/0963689718773363 |
| _version_ | 1828813784107450368 |
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| author | Liansheng Gao Weilin Xu Tao Li Jingyin Chen Anwen Shao Feng Yan Gao Chen |
| author_facet | Liansheng Gao Weilin Xu Tao Li Jingyin Chen Anwen Shao Feng Yan Gao Chen |
| author_sort | Liansheng Gao |
| collection | DOAJ |
| description | Spontaneous intracerebral hemorrhage (ICH) is one type of the most devastating cerebrovascular diseases worldwide, which causes high morbidity and mortality. However, efficient treatment is still lacking. Stem cell therapy has shown good neuroprotective and neurorestorative effect in ICH and is a promising treatment. In this study, our aim was to review the therapeutic effects, strategies, related mechanisms and safety issues of various types of stem cell for ICH treatment. Numerous studies had demonstrated the therapeutic effects of diverse stem cell types in ICH. The potential mechanisms include tissue repair and replacement, neurotrophy, promotion of neurogenesis and angiogenesis, anti-apoptosis, immunoregulation and anti-inflammation and so forth. The microenvironment of the central nervous system (CNS) can also influence the effects of stem cell therapy. The detailed therapeutic strategies for ICH treatment such as cell type, the number of cells, time window, and the routes of medication delivery, varied greatly among different studies and had not been determined. Moreover, the safety issues of stem cell therapy for ICH should not be ignored. Stem cell therapy showed good therapeutic effect in ICH, making it a promising treatment. However, safety should be carefully evaluated, and more clinical trials are required before stem cell therapy can be extensively applied to clinical use. |
| first_indexed | 2024-12-12T10:09:59Z |
| format | Article |
| id | doaj.art-16a5b4c9015e400590d2af4c859aeb6a |
| institution | Directory Open Access Journal |
| issn | 0963-6897 1555-3892 |
| language | English |
| last_indexed | 2024-12-12T10:09:59Z |
| publishDate | 2018-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj.art-16a5b4c9015e400590d2af4c859aeb6a2022-12-22T00:27:49ZengSAGE PublishingCell Transplantation0963-68971555-38922018-12-012710.1177/0963689718773363Stem Cell Therapy: A Promising Therapeutic Method for Intracerebral HemorrhageLiansheng Gao0Weilin Xu1Tao Li2Jingyin Chen3Anwen Shao4Feng Yan5Gao Chen6 Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, China Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, China Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, China Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, China Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, China Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, China Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, ChinaSpontaneous intracerebral hemorrhage (ICH) is one type of the most devastating cerebrovascular diseases worldwide, which causes high morbidity and mortality. However, efficient treatment is still lacking. Stem cell therapy has shown good neuroprotective and neurorestorative effect in ICH and is a promising treatment. In this study, our aim was to review the therapeutic effects, strategies, related mechanisms and safety issues of various types of stem cell for ICH treatment. Numerous studies had demonstrated the therapeutic effects of diverse stem cell types in ICH. The potential mechanisms include tissue repair and replacement, neurotrophy, promotion of neurogenesis and angiogenesis, anti-apoptosis, immunoregulation and anti-inflammation and so forth. The microenvironment of the central nervous system (CNS) can also influence the effects of stem cell therapy. The detailed therapeutic strategies for ICH treatment such as cell type, the number of cells, time window, and the routes of medication delivery, varied greatly among different studies and had not been determined. Moreover, the safety issues of stem cell therapy for ICH should not be ignored. Stem cell therapy showed good therapeutic effect in ICH, making it a promising treatment. However, safety should be carefully evaluated, and more clinical trials are required before stem cell therapy can be extensively applied to clinical use.https://doi.org/10.1177/0963689718773363 |
| spellingShingle | Liansheng Gao Weilin Xu Tao Li Jingyin Chen Anwen Shao Feng Yan Gao Chen Stem Cell Therapy: A Promising Therapeutic Method for Intracerebral Hemorrhage Cell Transplantation |
| title | Stem Cell Therapy: A Promising Therapeutic Method for Intracerebral Hemorrhage |
| title_full | Stem Cell Therapy: A Promising Therapeutic Method for Intracerebral Hemorrhage |
| title_fullStr | Stem Cell Therapy: A Promising Therapeutic Method for Intracerebral Hemorrhage |
| title_full_unstemmed | Stem Cell Therapy: A Promising Therapeutic Method for Intracerebral Hemorrhage |
| title_short | Stem Cell Therapy: A Promising Therapeutic Method for Intracerebral Hemorrhage |
| title_sort | stem cell therapy a promising therapeutic method for intracerebral hemorrhage |
| url | https://doi.org/10.1177/0963689718773363 |
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