Deep Insights in Circular RNAs: from biogenesis to therapeutics
Abstract Circular RNAs (circRNAs) have emerged as a universal novel class of eukaryotic non-coding RNA (ncRNA) molecules and are becoming a new research hotspot in RNA biology. They form a covalent loop without 5′ cap and 3′ tail, unlike their linear counterparts. Endogenous circRNAs in mammalian ce...
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| Format: | Article |
| Language: | English |
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BMC
2020-05-01
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| Series: | Biological Procedures Online |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12575-020-00122-8 |
| _version_ | 1818243948051693568 |
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| author | Peerzada Tajamul Mumtaz Qamar Taban Mashooq Ahmad Dar Shabir Mir Zulfkar ul Haq Sajad Majeed Zargar Riaz Ahmad Shah Syed Mudasir Ahmad |
| author_facet | Peerzada Tajamul Mumtaz Qamar Taban Mashooq Ahmad Dar Shabir Mir Zulfkar ul Haq Sajad Majeed Zargar Riaz Ahmad Shah Syed Mudasir Ahmad |
| author_sort | Peerzada Tajamul Mumtaz |
| collection | DOAJ |
| description | Abstract Circular RNAs (circRNAs) have emerged as a universal novel class of eukaryotic non-coding RNA (ncRNA) molecules and are becoming a new research hotspot in RNA biology. They form a covalent loop without 5′ cap and 3′ tail, unlike their linear counterparts. Endogenous circRNAs in mammalian cells are abundantly conserved and discovered so far. In the biogenesis of circRNAs exonic, intronic, reverse complementary sequences or RNA-binding proteins (RBPs) play a very important role. Interestingly, the majority of them are highly conserved, stable, resistant to RNase R and show developmental-stage/tissue-specific expression. CircRNAs play multifunctional roles as microRNA (miRNA) sponges, regulators of transcription and post-transcription, parental gene expression and translation of proteins in various diseased conditions. Growing evidence shows that circRNAs play an important role in neurological disorders, atherosclerotic vascular disease, and cancer and potentially serve as diagnostic or predictive biomarkers due to its abundance in various biological samples. Here, we review the biogenesis, properties, functions, and impact of circRNAs on various diseases. Graphical Abstract |
| first_indexed | 2024-12-12T14:09:14Z |
| format | Article |
| id | doaj.art-16a76da96dc14e2aac76fea1a2cda9a8 |
| institution | Directory Open Access Journal |
| issn | 1480-9222 |
| language | English |
| last_indexed | 2024-12-12T14:09:14Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Biological Procedures Online |
| spelling | doaj.art-16a76da96dc14e2aac76fea1a2cda9a82022-12-22T00:22:08ZengBMCBiological Procedures Online1480-92222020-05-0122111610.1186/s12575-020-00122-8Deep Insights in Circular RNAs: from biogenesis to therapeuticsPeerzada Tajamul Mumtaz0Qamar Taban1Mashooq Ahmad Dar2Shabir Mir3Zulfkar ul Haq4Sajad Majeed Zargar5Riaz Ahmad Shah6Syed Mudasir Ahmad7Division of Animal Biotechnology, Faculty of Veterinary Sciences and Animal Husbandry Shuhama, Sher-e- Kashmir University of Agricultural Sciences and TechnologyDivision of Animal Biotechnology, Faculty of Veterinary Sciences and Animal Husbandry Shuhama, Sher-e- Kashmir University of Agricultural Sciences and TechnologyDivision of Animal Biotechnology, Faculty of Veterinary Sciences and Animal Husbandry Shuhama, Sher-e- Kashmir University of Agricultural Sciences and TechnologyDivision of Animal Breeding and Genetics, Faculty of Veterinary Sciences and Animal Husbandry, Shuhama, SKUAST-KDivision of Livestock Production and Management, SKUAST-KDivision of Animal Biotechnology, Faculty of Veterinary Sciences and Animal Husbandry Shuhama, Sher-e- Kashmir University of Agricultural Sciences and TechnologyDivision of Animal Biotechnology, Faculty of Veterinary Sciences and Animal Husbandry Shuhama, Sher-e- Kashmir University of Agricultural Sciences and TechnologyDivision of Animal Biotechnology, Faculty of Veterinary Sciences and Animal Husbandry Shuhama, Sher-e- Kashmir University of Agricultural Sciences and TechnologyAbstract Circular RNAs (circRNAs) have emerged as a universal novel class of eukaryotic non-coding RNA (ncRNA) molecules and are becoming a new research hotspot in RNA biology. They form a covalent loop without 5′ cap and 3′ tail, unlike their linear counterparts. Endogenous circRNAs in mammalian cells are abundantly conserved and discovered so far. In the biogenesis of circRNAs exonic, intronic, reverse complementary sequences or RNA-binding proteins (RBPs) play a very important role. Interestingly, the majority of them are highly conserved, stable, resistant to RNase R and show developmental-stage/tissue-specific expression. CircRNAs play multifunctional roles as microRNA (miRNA) sponges, regulators of transcription and post-transcription, parental gene expression and translation of proteins in various diseased conditions. Growing evidence shows that circRNAs play an important role in neurological disorders, atherosclerotic vascular disease, and cancer and potentially serve as diagnostic or predictive biomarkers due to its abundance in various biological samples. Here, we review the biogenesis, properties, functions, and impact of circRNAs on various diseases. Graphical Abstracthttp://link.springer.com/article/10.1186/s12575-020-00122-8Circular RNABiogenesisMicroRNA spongeGene expression regulationDisease biomarker |
| spellingShingle | Peerzada Tajamul Mumtaz Qamar Taban Mashooq Ahmad Dar Shabir Mir Zulfkar ul Haq Sajad Majeed Zargar Riaz Ahmad Shah Syed Mudasir Ahmad Deep Insights in Circular RNAs: from biogenesis to therapeutics Biological Procedures Online Circular RNA Biogenesis MicroRNA sponge Gene expression regulation Disease biomarker |
| title | Deep Insights in Circular RNAs: from biogenesis to therapeutics |
| title_full | Deep Insights in Circular RNAs: from biogenesis to therapeutics |
| title_fullStr | Deep Insights in Circular RNAs: from biogenesis to therapeutics |
| title_full_unstemmed | Deep Insights in Circular RNAs: from biogenesis to therapeutics |
| title_short | Deep Insights in Circular RNAs: from biogenesis to therapeutics |
| title_sort | deep insights in circular rnas from biogenesis to therapeutics |
| topic | Circular RNA Biogenesis MicroRNA sponge Gene expression regulation Disease biomarker |
| url | http://link.springer.com/article/10.1186/s12575-020-00122-8 |
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