Escalating Bi-Directional Feedback Loops between Proinflammatory Microglia and Mitochondria in Ageing and Post-Diagnosis of Parkinson’s Disease

Escalating Bi-Directional Feedback Loops between Proinflammatory Microglia and Mitochondria in Ageing and Post-Diagnosis of Parkinson’s Disease

Parkinson’s disease (PD) is a chronic and progressive age-related neurodegenerative disease affecting up to 3% of the global population over 65 years of age. Currently, the underlying physiological aetiology of PD is unknown. However, the diagnosed disorder shares many common non-motor symptoms asso...

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Bibliographic Details
Main Authors: Shane Michael Ravenhill, Andrew Howard Evans, Sheila Gillard Crewther
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Antioxidants
Subjects:
alpha-synuclein
adenosine triphosphate
bioenergetic capacity
cytokines
dopamine neurons
homeostasis
Online Access:https://www.mdpi.com/2076-3921/12/5/1117

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