Identification of cis-regulatory mutations generating de novo edges in personalized cancer gene regulatory networks

Identification of cis-regulatory mutations generating de novo edges in personalized cancer gene regulatory networks

Abstract The identification of functional non-coding mutations is a key challenge in the field of genomics. Here we introduce μ-cisTarget to filter, annotate and prioritize cis-regulatory mutations based on their putative effect on the underlying “personal” gene regulatory network. We validated μ-ci...

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Bibliographic Details
Main Authors: Zeynep Kalender Atak, Hana Imrichova, Dmitry Svetlichnyy, Gert Hulselmans, Valerie Christiaens, Joke Reumers, Hugo Ceulemans, Stein Aerts
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Genome Medicine
Subjects:
cis-regulatory mutations
Whole-genome sequencing
Gene regulatory networks
Cancer genomics
Online Access:http://link.springer.com/article/10.1186/s13073-017-0464-7

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