HMBOX1, a member of the homeobox family: current research progress
Homeobox containing 1 (HMBOX1) is a transcription factor that was identified in 2006 from a cDNA library of the human pancreas. It belongs to the HNF gene class of the homeobox family. HMBOX1 is widely expressed in normal human tissues; however, its expression level is rather uneven. Homeobox member...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2023-04-01
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| Series: | Central European Journal of Immunology |
| Subjects: | |
| Online Access: | https://www.termedia.pl/HMBOX1-a-member-of-the-homeobox-family-current-research-progress,10,50543,1,1.html |
| _version_ | 1797692373463990272 |
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| author | Yu Jiang Hongli Mu Hengli Zhao |
| author_facet | Yu Jiang Hongli Mu Hengli Zhao |
| author_sort | Yu Jiang |
| collection | DOAJ |
| description | Homeobox containing 1 (HMBOX1) is a transcription factor that was identified in 2006 from a cDNA library of the human pancreas. It belongs to the HNF gene class of the homeobox family. HMBOX1 is widely expressed in normal human tissues; however, its expression level is rather uneven. Homeobox members have been widely reported to participate in embryonic development and differentiation as well as in pathological and physiological processes. Although research on the role of HMBOX1 is still in its infancy, many reports have revealed its regulatory role in cell differentiation, immune regulation, inflammation, and tumor progression. HMBOX1 plays an important role in promoting the differentiation of bone marrow stromal stem cells (BMSCs) into endothelial cells and contributes to their physiological functions. As an immunoregulatory factor, HMBOX1 can significantly inhibit the inflammatory response in hepatocytes and NK cells and impede the infiltration of peripheral immune cells to the liver. In tumor development, HMBOX1 exerts diametrically opposite biological functions, inhibiting or promoting the process. HMBOX1 possesses complex and diverse biological functions. In this review, we provide a brief overview of the research on HMBOX1. |
| first_indexed | 2024-03-12T02:26:42Z |
| format | Article |
| id | doaj.art-16a9cdd8409940398321d5c74313d1eb |
| institution | Directory Open Access Journal |
| issn | 1426-3912 1644-4124 |
| language | English |
| last_indexed | 2024-03-12T02:26:42Z |
| publishDate | 2023-04-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Central European Journal of Immunology |
| spelling | doaj.art-16a9cdd8409940398321d5c74313d1eb2023-09-05T11:42:07ZengTermedia Publishing HouseCentral European Journal of Immunology1426-39121644-41242023-04-01481636910.5114/ceji.2023.12661550543HMBOX1, a member of the homeobox family: current research progressYu JiangHongli MuHengli ZhaoHomeobox containing 1 (HMBOX1) is a transcription factor that was identified in 2006 from a cDNA library of the human pancreas. It belongs to the HNF gene class of the homeobox family. HMBOX1 is widely expressed in normal human tissues; however, its expression level is rather uneven. Homeobox members have been widely reported to participate in embryonic development and differentiation as well as in pathological and physiological processes. Although research on the role of HMBOX1 is still in its infancy, many reports have revealed its regulatory role in cell differentiation, immune regulation, inflammation, and tumor progression. HMBOX1 plays an important role in promoting the differentiation of bone marrow stromal stem cells (BMSCs) into endothelial cells and contributes to their physiological functions. As an immunoregulatory factor, HMBOX1 can significantly inhibit the inflammatory response in hepatocytes and NK cells and impede the infiltration of peripheral immune cells to the liver. In tumor development, HMBOX1 exerts diametrically opposite biological functions, inhibiting or promoting the process. HMBOX1 possesses complex and diverse biological functions. In this review, we provide a brief overview of the research on HMBOX1.https://www.termedia.pl/HMBOX1-a-member-of-the-homeobox-family-current-research-progress,10,50543,1,1.htmlhomeobox containing 1 cell differentiation tumor progression immune regulation |
| spellingShingle | Yu Jiang Hongli Mu Hengli Zhao HMBOX1, a member of the homeobox family: current research progress Central European Journal of Immunology homeobox containing 1 cell differentiation tumor progression immune regulation |
| title | HMBOX1, a member of the homeobox family: current research progress |
| title_full | HMBOX1, a member of the homeobox family: current research progress |
| title_fullStr | HMBOX1, a member of the homeobox family: current research progress |
| title_full_unstemmed | HMBOX1, a member of the homeobox family: current research progress |
| title_short | HMBOX1, a member of the homeobox family: current research progress |
| title_sort | hmbox1 a member of the homeobox family current research progress |
| topic | homeobox containing 1 cell differentiation tumor progression immune regulation |
| url | https://www.termedia.pl/HMBOX1-a-member-of-the-homeobox-family-current-research-progress,10,50543,1,1.html |
| work_keys_str_mv | AT yujiang hmbox1amemberofthehomeoboxfamilycurrentresearchprogress AT honglimu hmbox1amemberofthehomeoboxfamilycurrentresearchprogress AT henglizhao hmbox1amemberofthehomeoboxfamilycurrentresearchprogress |