What Dietary Vitamins and Minerals Might Be Protective against Parkinson’s Disease?
Background and Objective: Dietary constituents may affect the progression of Parkinson’s disease (PD). This study aimed to assess the contribution of dietary intake of vitamins and minerals to the severity, motor and non-motor symptoms, and risk of PD. Methods: In this case-control study, 120 patien...
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| Format: | Article |
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MDPI AG
2023-07-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/7/1119 |
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| author | Mohammad Alizadeh Sorayya Kheirouri Majid Keramati |
| author_facet | Mohammad Alizadeh Sorayya Kheirouri Majid Keramati |
| author_sort | Mohammad Alizadeh |
| collection | DOAJ |
| description | Background and Objective: Dietary constituents may affect the progression of Parkinson’s disease (PD). This study aimed to assess the contribution of dietary intake of vitamins and minerals to the severity, motor and non-motor symptoms, and risk of PD. Methods: In this case-control study, 120 patients with PD and 50 healthy participants participated. Dietary intake of vitamins and minerals was determined using a 147-item food frequency questionnaire. The severity of PD was determined by the Unified Parkinson’s Disease Rating Scale (UPDRS). Results: Patients with PD had lower intake of several vitamins and minerals including lycopene, thiamine, vitamin B6, vitamin B12, pantothenic acid, magnesium, zinc, manganese, selenium, chromium, and phosphorus, but had higher intake of α-tocopherol. High dietary intake of vitamin A, α-carotene, β-cryptoxanthin, vitamin C, and α-tocopherol were correlated with increased odds of PD. High intake of lycopene, thiamin, vitamin B6, pantothenic acid, magnesium, zinc, manganese, chromium, and phosphorous correlated with reduced odds of PD. The predictive power of α-tocopherol concerning the risk of PD was stronger relative to other vitamins. Dietary intake of pantothenic acid was negatively correlated with PD severity and symptoms of motor examination and complication. The severity and motor symptoms of PD were also negatively correlated with β-carotene, vitamin C, riboflavin, vitamin B6, and biotin intake. The UPDRS total score and motor symptoms in PD patients were negatively correlated with phosphorus, magnesium, zinc, manganese, and chromium, and strongly with potassium intake. Conclusion: The findings indicate that adequate dietary intake of vitamins and minerals may have a preventive effect on developing PD and progression of motor decline. |
| first_indexed | 2024-03-11T01:14:16Z |
| format | Article |
| id | doaj.art-16a9da6fb3b241c2964c4a3e874d1b04 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-11T01:14:16Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-16a9da6fb3b241c2964c4a3e874d1b042023-11-18T18:35:39ZengMDPI AGBrain Sciences2076-34252023-07-01137111910.3390/brainsci13071119What Dietary Vitamins and Minerals Might Be Protective against Parkinson’s Disease?Mohammad Alizadeh0Sorayya Kheirouri1Majid Keramati2Department of Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz 5166614711, IranDepartment of Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz 5166614711, IranDepartment of Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz 5166614711, IranBackground and Objective: Dietary constituents may affect the progression of Parkinson’s disease (PD). This study aimed to assess the contribution of dietary intake of vitamins and minerals to the severity, motor and non-motor symptoms, and risk of PD. Methods: In this case-control study, 120 patients with PD and 50 healthy participants participated. Dietary intake of vitamins and minerals was determined using a 147-item food frequency questionnaire. The severity of PD was determined by the Unified Parkinson’s Disease Rating Scale (UPDRS). Results: Patients with PD had lower intake of several vitamins and minerals including lycopene, thiamine, vitamin B6, vitamin B12, pantothenic acid, magnesium, zinc, manganese, selenium, chromium, and phosphorus, but had higher intake of α-tocopherol. High dietary intake of vitamin A, α-carotene, β-cryptoxanthin, vitamin C, and α-tocopherol were correlated with increased odds of PD. High intake of lycopene, thiamin, vitamin B6, pantothenic acid, magnesium, zinc, manganese, chromium, and phosphorous correlated with reduced odds of PD. The predictive power of α-tocopherol concerning the risk of PD was stronger relative to other vitamins. Dietary intake of pantothenic acid was negatively correlated with PD severity and symptoms of motor examination and complication. The severity and motor symptoms of PD were also negatively correlated with β-carotene, vitamin C, riboflavin, vitamin B6, and biotin intake. The UPDRS total score and motor symptoms in PD patients were negatively correlated with phosphorus, magnesium, zinc, manganese, and chromium, and strongly with potassium intake. Conclusion: The findings indicate that adequate dietary intake of vitamins and minerals may have a preventive effect on developing PD and progression of motor decline.https://www.mdpi.com/2076-3425/13/7/1119Parkinson’s diseasedietary intakevitaminsmineralslycopenethiamine |
| spellingShingle | Mohammad Alizadeh Sorayya Kheirouri Majid Keramati What Dietary Vitamins and Minerals Might Be Protective against Parkinson’s Disease? Brain Sciences Parkinson’s disease dietary intake vitamins minerals lycopene thiamine |
| title | What Dietary Vitamins and Minerals Might Be Protective against Parkinson’s Disease? |
| title_full | What Dietary Vitamins and Minerals Might Be Protective against Parkinson’s Disease? |
| title_fullStr | What Dietary Vitamins and Minerals Might Be Protective against Parkinson’s Disease? |
| title_full_unstemmed | What Dietary Vitamins and Minerals Might Be Protective against Parkinson’s Disease? |
| title_short | What Dietary Vitamins and Minerals Might Be Protective against Parkinson’s Disease? |
| title_sort | what dietary vitamins and minerals might be protective against parkinson s disease |
| topic | Parkinson’s disease dietary intake vitamins minerals lycopene thiamine |
| url | https://www.mdpi.com/2076-3425/13/7/1119 |
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