Structure of the human marker of self 5-transmembrane receptor CD47
CD47 is a transmembrane receptor involved in the regulation of various signalling pathways and a promising target for immuno-oncology therapeutics. Here, the authors present the crystal structure of full-length human CD47 and provide insights into the molecular mechanism of CD47-mediated signalling.
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25475-w |
| _version_ | 1818840884381220864 |
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| author | Gustavo Fenalti Nicolas Villanueva Mark Griffith Barbra Pagarigan Sirish Kaushik Lakkaraju Richard Y.-C. Huang Nadia Ladygina Alok Sharma David Mikolon Mahan Abbasian Jeffrey Johnson Haralambos Hadjivassiliou Dan Zhu Philip P. Chamberlain Ho Cho Kandasamy Hariharan |
| author_facet | Gustavo Fenalti Nicolas Villanueva Mark Griffith Barbra Pagarigan Sirish Kaushik Lakkaraju Richard Y.-C. Huang Nadia Ladygina Alok Sharma David Mikolon Mahan Abbasian Jeffrey Johnson Haralambos Hadjivassiliou Dan Zhu Philip P. Chamberlain Ho Cho Kandasamy Hariharan |
| author_sort | Gustavo Fenalti |
| collection | DOAJ |
| description | CD47 is a transmembrane receptor involved in the regulation of various signalling pathways and a promising target for immuno-oncology therapeutics. Here, the authors present the crystal structure of full-length human CD47 and provide insights into the molecular mechanism of CD47-mediated signalling. |
| first_indexed | 2024-12-19T04:17:17Z |
| format | Article |
| id | doaj.art-16ac1202277e490cac61cc68b1c66fb7 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:17:17Z |
| publishDate | 2021-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-16ac1202277e490cac61cc68b1c66fb72022-12-21T20:36:16ZengNature PortfolioNature Communications2041-17232021-09-0112111410.1038/s41467-021-25475-wStructure of the human marker of self 5-transmembrane receptor CD47Gustavo Fenalti0Nicolas Villanueva1Mark Griffith2Barbra Pagarigan3Sirish Kaushik Lakkaraju4Richard Y.-C. Huang5Nadia Ladygina6Alok Sharma7David Mikolon8Mahan Abbasian9Jeffrey Johnson10Haralambos Hadjivassiliou11Dan Zhu12Philip P. Chamberlain13Ho Cho14Kandasamy Hariharan15Molecular Structure and Design, Bristol Myers SquibbMolecular Structure and Design, Bristol Myers SquibbProtein Homeostasis, Bristol Myers SquibbMolecular Structure and Design, Bristol Myers SquibbMolecular Structure and Design, Bristol Myers SquibbPharmaceutical Candidate Optimization, Nonclinical Research and Development, Bristol Myers SquibbPharmacology, Bristol Myers SquibbMolecular Structure and Design, Bristol Myers SquibbDiscovery Biotherapeutics, Bristol Myers SquibbDiscovery Biotherapeutics, Bristol Myers SquibbDiscovery Biotherapeutics, Bristol Myers SquibbDiscovery Biotherapeutics, Bristol Myers SquibbDiscovery Biotherapeutics, Bristol Myers SquibbProtein Homeostasis, Bristol Myers SquibbDiscovery Biotherapeutics, Bristol Myers SquibbDiscovery Biotherapeutics, Bristol Myers SquibbCD47 is a transmembrane receptor involved in the regulation of various signalling pathways and a promising target for immuno-oncology therapeutics. Here, the authors present the crystal structure of full-length human CD47 and provide insights into the molecular mechanism of CD47-mediated signalling.https://doi.org/10.1038/s41467-021-25475-w |
| spellingShingle | Gustavo Fenalti Nicolas Villanueva Mark Griffith Barbra Pagarigan Sirish Kaushik Lakkaraju Richard Y.-C. Huang Nadia Ladygina Alok Sharma David Mikolon Mahan Abbasian Jeffrey Johnson Haralambos Hadjivassiliou Dan Zhu Philip P. Chamberlain Ho Cho Kandasamy Hariharan Structure of the human marker of self 5-transmembrane receptor CD47 Nature Communications |
| title | Structure of the human marker of self 5-transmembrane receptor CD47 |
| title_full | Structure of the human marker of self 5-transmembrane receptor CD47 |
| title_fullStr | Structure of the human marker of self 5-transmembrane receptor CD47 |
| title_full_unstemmed | Structure of the human marker of self 5-transmembrane receptor CD47 |
| title_short | Structure of the human marker of self 5-transmembrane receptor CD47 |
| title_sort | structure of the human marker of self 5 transmembrane receptor cd47 |
| url | https://doi.org/10.1038/s41467-021-25475-w |
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