Structure of the human marker of self 5-transmembrane receptor CD47

Structure of the human marker of self 5-transmembrane receptor CD47

CD47 is a transmembrane receptor involved in the regulation of various signalling pathways and a promising target for immuno-oncology therapeutics. Here, the authors present the crystal structure of full-length human CD47 and provide insights into the molecular mechanism of CD47-mediated signalling.

Bibliographic Details
Main Authors: Gustavo Fenalti, Nicolas Villanueva, Mark Griffith, Barbra Pagarigan, Sirish Kaushik Lakkaraju, Richard Y.-C. Huang, Nadia Ladygina, Alok Sharma, David Mikolon, Mahan Abbasian, Jeffrey Johnson, Haralambos Hadjivassiliou, Dan Zhu, Philip P. Chamberlain, Ho Cho, Kandasamy Hariharan
Format: Article
Language:English
Published: Nature Portfolio 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25475-w

Internet

https://doi.org/10.1038/s41467-021-25475-w

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