Mineralizing Gelatin Microparticles as Cell Carrier and Drug Delivery System for siRNA for Bone Tissue Engineering

Mineralizing Gelatin Microparticles as Cell Carrier and Drug Delivery System for siRNA for Bone Tissue Engineering

The local release of complexed siRNA from biomaterials opens precisely targeted therapeutic options. In this study, complexed siRNA was loaded to gelatin microparticles cross-linked (cGM) with an anhydride-containing oligomer (oPNMA). We aggregated these siRNA-loaded cGM with human mesenchymal stem...

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Bibliographic Details
Main Authors:	Sandra Hinkelmann, Alexandra H. Springwald, Sabine Schulze, Ute Hempel, Franziska Mitrach, Christian Wölk, Michael C. Hacker, Michaela Schulz-Siegmund
Format:	Article
Language:	English
Published:	MDPI AG 2022-02-01
Series:	Pharmaceutics
Subjects:	chordin silencing human mesenchymal stem cells (hMSC) human peripheral blood mononuclear cells (hPBMC) gelatin microparticles osteogenic differentiation co-culture
Online Access:	https://www.mdpi.com/1999-4923/14/3/548

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