Patterns in Psychiatrists’ Prescription of Valproate for Female Patients of Childbearing Age With Bipolar Disorder in Japan: A Questionnaire Survey
BackgroundAccumulating evidence has shown that valproate has the greatest teratogenic potential for increasing the risk of major congenital malformations, such as neural tube defects, cleft palate, and neurodevelopmental disability. Although valproate is a pharmacological option for acute mania and...
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Frontiers Media S.A.
2020-04-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00250/full |
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| author | Masumi Tachibana Tasuku Hashimoto Tasuku Hashimoto Mami Tanaka Hiroyuki Watanabe Hiroyuki Watanabe Yasunori Sato Takashi Takeuchi Takeshi Terao Shou Kimura Akio Koyama Sachie Ebisawa Yuichiro Shizu Teruyoshi Nagase Junichi Hirakawa Kotaro Hatta Michiko Nakazato Michiko Nakazato Masaomi Iyo |
| author_facet | Masumi Tachibana Tasuku Hashimoto Tasuku Hashimoto Mami Tanaka Hiroyuki Watanabe Hiroyuki Watanabe Yasunori Sato Takashi Takeuchi Takeshi Terao Shou Kimura Akio Koyama Sachie Ebisawa Yuichiro Shizu Teruyoshi Nagase Junichi Hirakawa Kotaro Hatta Michiko Nakazato Michiko Nakazato Masaomi Iyo |
| author_sort | Masumi Tachibana |
| collection | DOAJ |
| description | BackgroundAccumulating evidence has shown that valproate has the greatest teratogenic potential for increasing the risk of major congenital malformations, such as neural tube defects, cleft palate, and neurodevelopmental disability. Although valproate is a pharmacological option for acute mania and is used as a stabilization drug for patients with bipolar disorder, some global guidelines state that valproate should not be used for girls or women of childbearing age with bipolar disorder. We investigated patterns in psychiatrists' prescription of valproate for bipolar female patients of childbearing age in Japan.MethodsFrom March to May 2018, we conducted a questionnaire survey among psychiatrists from all prefectures in Japan on psychiatric practice as it relates to major depression and bipolar disorder throughout women's life. The questionnaire had two parts: (1) assessment of participating psychiatrists' backgrounds and attitudes toward patients and (2) their patterns of prescription of psychotropics for female patients with mood disorders across generations and periods of pregnancy. Each question item had four response options: “not at all,” “rarely,” “sometimes,” and “frequently.” We examined patterns of prescription for childbearing-aged women (late adolescence/young adulthood aged 18–24 years, childbearing-age, older adults aged 25–49 years) and pregnant women.ResultsIn total, 571 psychiatrists (427 males, 123 females, and 21 unknowns) responded appropriately to the questionnaire, including 320 who examined at least one or more late adolescence/young adulthood bipolar women. Approximately 70% of psychiatrists answered that they frequently or sometimes prescribed valproate for bipolar women of childbearing age [late adolescence/young adulthood: not at all, n = 23 (7.5%); rarely, n = 69 (22.5%); sometimes, n =116 (37.8%); and frequently, n = 99 (32.2%); childbearing-age, older adults: not at all, n = 13 (2.7%); rarely, n = 67 (13.8%); sometimes, n = 185 (38.1%); and frequently, n = 220 (45.4%)]. The proportion of general hospital psychiatrists who answered “not at all” or “rarely” to the frequency of their valproate prescriptions was higher than that of psychiatrists working in other medical facilities (χ2(3) = 18.2, p < 0.001).ConclusionMost psychiatrists frequently or sometimes prescribe valproate for women of childbearing age in Japan. |
| first_indexed | 2024-12-13T03:06:17Z |
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| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-13T03:06:17Z |
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| series | Frontiers in Psychiatry |
| spelling | doaj.art-16ad7c0aed3e424ba6a082a3ce5f1d1c2022-12-22T00:01:43ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402020-04-011110.3389/fpsyt.2020.00250518637Patterns in Psychiatrists’ Prescription of Valproate for Female Patients of Childbearing Age With Bipolar Disorder in Japan: A Questionnaire SurveyMasumi Tachibana0Tasuku Hashimoto1Tasuku Hashimoto2Mami Tanaka3Hiroyuki Watanabe4Hiroyuki Watanabe5Yasunori Sato6Takashi Takeuchi7Takeshi Terao8Shou Kimura9Akio Koyama10Sachie Ebisawa11Yuichiro Shizu12Teruyoshi Nagase13Junichi Hirakawa14Kotaro Hatta15Michiko Nakazato16Michiko Nakazato17Masaomi Iyo18Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, JapanDepartment of Psychiatry, Chiba University Graduate School of Medicine, Chiba, JapanDepartment of Psychiatry, Sodegaura-Satsukidai Hospital, Sodegaura, JapanDivision of Clinical Study on Juvenile Delinquency, Center for Forensic Mental Health, Chiba University, Chiba, JapanDivision of Medical Treatment and Rehabilitation, Chiba University Center for Forensic Mental Health, Chiba, JapanDepartment of Psychiatry, Gakuji-kai Kimura Hospital, Chiba, JapanDepartment of Preventive Medicine and Public Health, School of Medicine, Keio University, Tokyo, JapanDepartment of Psychosomatic and Palliative Medicine, Tokyo Medical and Dental University Medical Hospital, Bunkyo-ku, JapanDepartment of Neuropsychiatry, Faculty of Medicine, Oita University Yufu, Oita, JapanDepartment of Psychiatry, Gakuji-kai Kimura Hospital, Chiba, JapanDepartment of Psychiatry, Yurakucho Sakura Clinic, Chiyoda-ku, Japan0Department of Psychiatry, Alba Mental Clinic, Shinjuku, Japan1Shizu Clinic, Sakura, Japan2Department of Psychiatry, Takatsuki Hospital, Hachioji, Japan3Department of Psychiatry, Hirakawa Hospital, Hachioji, Japan4Department of Psychiatry, Juntendo University Nerima Hospital, Nerima-ku, JapanDepartment of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan5Department of Psychiatry, International University of Health and Welfare Graduate School, Narita, JapanDepartment of Psychiatry, Chiba University Graduate School of Medicine, Chiba, JapanBackgroundAccumulating evidence has shown that valproate has the greatest teratogenic potential for increasing the risk of major congenital malformations, such as neural tube defects, cleft palate, and neurodevelopmental disability. Although valproate is a pharmacological option for acute mania and is used as a stabilization drug for patients with bipolar disorder, some global guidelines state that valproate should not be used for girls or women of childbearing age with bipolar disorder. We investigated patterns in psychiatrists' prescription of valproate for bipolar female patients of childbearing age in Japan.MethodsFrom March to May 2018, we conducted a questionnaire survey among psychiatrists from all prefectures in Japan on psychiatric practice as it relates to major depression and bipolar disorder throughout women's life. The questionnaire had two parts: (1) assessment of participating psychiatrists' backgrounds and attitudes toward patients and (2) their patterns of prescription of psychotropics for female patients with mood disorders across generations and periods of pregnancy. Each question item had four response options: “not at all,” “rarely,” “sometimes,” and “frequently.” We examined patterns of prescription for childbearing-aged women (late adolescence/young adulthood aged 18–24 years, childbearing-age, older adults aged 25–49 years) and pregnant women.ResultsIn total, 571 psychiatrists (427 males, 123 females, and 21 unknowns) responded appropriately to the questionnaire, including 320 who examined at least one or more late adolescence/young adulthood bipolar women. Approximately 70% of psychiatrists answered that they frequently or sometimes prescribed valproate for bipolar women of childbearing age [late adolescence/young adulthood: not at all, n = 23 (7.5%); rarely, n = 69 (22.5%); sometimes, n =116 (37.8%); and frequently, n = 99 (32.2%); childbearing-age, older adults: not at all, n = 13 (2.7%); rarely, n = 67 (13.8%); sometimes, n = 185 (38.1%); and frequently, n = 220 (45.4%)]. The proportion of general hospital psychiatrists who answered “not at all” or “rarely” to the frequency of their valproate prescriptions was higher than that of psychiatrists working in other medical facilities (χ2(3) = 18.2, p < 0.001).ConclusionMost psychiatrists frequently or sometimes prescribe valproate for women of childbearing age in Japan.https://www.frontiersin.org/article/10.3389/fpsyt.2020.00250/fullbipolar disorderchildbearing-age womencongenital malformationspharmacoepidemiologypregnancyvalproate |
| spellingShingle | Masumi Tachibana Tasuku Hashimoto Tasuku Hashimoto Mami Tanaka Hiroyuki Watanabe Hiroyuki Watanabe Yasunori Sato Takashi Takeuchi Takeshi Terao Shou Kimura Akio Koyama Sachie Ebisawa Yuichiro Shizu Teruyoshi Nagase Junichi Hirakawa Kotaro Hatta Michiko Nakazato Michiko Nakazato Masaomi Iyo Patterns in Psychiatrists’ Prescription of Valproate for Female Patients of Childbearing Age With Bipolar Disorder in Japan: A Questionnaire Survey Frontiers in Psychiatry bipolar disorder childbearing-age women congenital malformations pharmacoepidemiology pregnancy valproate |
| title | Patterns in Psychiatrists’ Prescription of Valproate for Female Patients of Childbearing Age With Bipolar Disorder in Japan: A Questionnaire Survey |
| title_full | Patterns in Psychiatrists’ Prescription of Valproate for Female Patients of Childbearing Age With Bipolar Disorder in Japan: A Questionnaire Survey |
| title_fullStr | Patterns in Psychiatrists’ Prescription of Valproate for Female Patients of Childbearing Age With Bipolar Disorder in Japan: A Questionnaire Survey |
| title_full_unstemmed | Patterns in Psychiatrists’ Prescription of Valproate for Female Patients of Childbearing Age With Bipolar Disorder in Japan: A Questionnaire Survey |
| title_short | Patterns in Psychiatrists’ Prescription of Valproate for Female Patients of Childbearing Age With Bipolar Disorder in Japan: A Questionnaire Survey |
| title_sort | patterns in psychiatrists prescription of valproate for female patients of childbearing age with bipolar disorder in japan a questionnaire survey |
| topic | bipolar disorder childbearing-age women congenital malformations pharmacoepidemiology pregnancy valproate |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00250/full |
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