Non-crossover gene conversions show strong GC bias and unexpected clustering in humans

Non-crossover gene conversions show strong GC bias and unexpected clustering in humans

Although the past decade has seen tremendous progress in our understanding of fine-scale recombination, little is known about non-crossover (NCO) gene conversion. We report the first genome-wide study of NCO events in humans. Using SNP array data from 98 meioses, we identified 103 sites affected by...

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Bibliographic Details
Main Authors: Amy L Williams, Giulio Genovese, Thomas Dyer, Nicolas Altemose, Katherine Truax, Goo Jun, Nick Patterson, Simon R Myers, Joanne E Curran, Ravi Duggirala, John Blangero, David Reich, Molly Przeworski, on behalf of the T2D-GENES Consortium
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-03-01
Series:eLife
Subjects:
recombination
non-crossover
gene conversion
GC-bias
complex crossover
haplotype
Online Access:https://elifesciences.org/articles/04637

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