Hyperhomocysteinemia in Patients with Parkinson’s Disease and Relationship to Vitamin B Level
Background: Plasma homocysteine (Hcy) levels are increased in patients with Parkinson’s disease (PD) undergoing levodopa treatment. We measured the Hcy levels in PD patients and assessed the relationship between Hcy level and features of PD, cognitive function and vitamin B status. Methods: Concentr...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Movement Disorder Society
2009-05-01
|
| Series: | Journal of Movement Disorders |
| Subjects: | |
| Online Access: | http://e-jmd.org/upload/jmd-2-1-33-8.pdf |
| _version_ | 1827882972825518080 |
|---|---|
| author | Hae-Won Shin Young Ho Sohn |
| author_facet | Hae-Won Shin Young Ho Sohn |
| author_sort | Hae-Won Shin |
| collection | DOAJ |
| description | Background: Plasma homocysteine (Hcy) levels are increased in patients with Parkinson’s disease (PD) undergoing levodopa treatment. We measured the Hcy levels in PD patients and assessed the relationship between Hcy level and features of PD, cognitive function and vitamin B status. Methods: Concentrations of Hcy, vitamin B12 and folate were measured in 33 PD patients and 41 normal control individuals. Mini-mental Status Examination (MMSE) was assessed in all subjects. In PD patients, Hoehn & Yahr stage and Unified Parkinson Disease Rating Scale (UPDRS) motor scores were also examined. Results: Plasma Hcy levels were lower in PD patients than in control individuals. Hcy level was inversely correlated with vitamin B12 and folate levels in the PD group but not in control individuals. Age, symptom duration, UPDRS motor scores, MMSE score, levodopa dose and duration of treatment did not differ between patients with Hcy >14 μmol/L and those with Hcy <14 μmol/L. Conclusions: Plasma Hcy levels were increased in PD patients with levodopa treatment and were related to vitamin B level. These results indicate that vitamin supplementation may be beneficial in levodopa-treated PD patients, although hyperhomocysteinemia did not affect the motor and cognitive status of PD patients. |
| first_indexed | 2024-03-12T19:04:54Z |
| format | Article |
| id | doaj.art-16aee3e4fb4e42f2a6a4e9af3021d623 |
| institution | Directory Open Access Journal |
| issn | 2005-940X 2093-4939 |
| language | English |
| last_indexed | 2024-03-12T19:04:54Z |
| publishDate | 2009-05-01 |
| publisher | Korean Movement Disorder Society |
| record_format | Article |
| series | Journal of Movement Disorders |
| spelling | doaj.art-16aee3e4fb4e42f2a6a4e9af3021d6232023-08-02T06:17:09ZengKorean Movement Disorder SocietyJournal of Movement Disorders2005-940X2093-49392009-05-0121333610.14802/jmd.0900895Hyperhomocysteinemia in Patients with Parkinson’s Disease and Relationship to Vitamin B LevelHae-Won ShinYoung Ho SohnBackground: Plasma homocysteine (Hcy) levels are increased in patients with Parkinson’s disease (PD) undergoing levodopa treatment. We measured the Hcy levels in PD patients and assessed the relationship between Hcy level and features of PD, cognitive function and vitamin B status. Methods: Concentrations of Hcy, vitamin B12 and folate were measured in 33 PD patients and 41 normal control individuals. Mini-mental Status Examination (MMSE) was assessed in all subjects. In PD patients, Hoehn & Yahr stage and Unified Parkinson Disease Rating Scale (UPDRS) motor scores were also examined. Results: Plasma Hcy levels were lower in PD patients than in control individuals. Hcy level was inversely correlated with vitamin B12 and folate levels in the PD group but not in control individuals. Age, symptom duration, UPDRS motor scores, MMSE score, levodopa dose and duration of treatment did not differ between patients with Hcy >14 μmol/L and those with Hcy <14 μmol/L. Conclusions: Plasma Hcy levels were increased in PD patients with levodopa treatment and were related to vitamin B level. These results indicate that vitamin supplementation may be beneficial in levodopa-treated PD patients, although hyperhomocysteinemia did not affect the motor and cognitive status of PD patients.http://e-jmd.org/upload/jmd-2-1-33-8.pdfParkinson’s diseaseHomocysteineVitamin B |
| spellingShingle | Hae-Won Shin Young Ho Sohn Hyperhomocysteinemia in Patients with Parkinson’s Disease and Relationship to Vitamin B Level Journal of Movement Disorders Parkinson’s disease Homocysteine Vitamin B |
| title | Hyperhomocysteinemia in Patients with Parkinson’s Disease and Relationship to Vitamin B Level |
| title_full | Hyperhomocysteinemia in Patients with Parkinson’s Disease and Relationship to Vitamin B Level |
| title_fullStr | Hyperhomocysteinemia in Patients with Parkinson’s Disease and Relationship to Vitamin B Level |
| title_full_unstemmed | Hyperhomocysteinemia in Patients with Parkinson’s Disease and Relationship to Vitamin B Level |
| title_short | Hyperhomocysteinemia in Patients with Parkinson’s Disease and Relationship to Vitamin B Level |
| title_sort | hyperhomocysteinemia in patients with parkinson s disease and relationship to vitamin b level |
| topic | Parkinson’s disease Homocysteine Vitamin B |
| url | http://e-jmd.org/upload/jmd-2-1-33-8.pdf |
| work_keys_str_mv | AT haewonshin hyperhomocysteinemiainpatientswithparkinsonsdiseaseandrelationshiptovitaminblevel AT younghosohn hyperhomocysteinemiainpatientswithparkinsonsdiseaseandrelationshiptovitaminblevel |