Autophagy mediates phase transitions from cell death to life
Autophagy is a lysosomal degradation pathway, which is critical for maintaining normal cellular functions. Despite considerable advances in defining the specific molecular mechanism governing the autophagy pathway during the last decades, we are still far from understanding the underlying principle...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-09-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844015302929 |
| _version_ | 1818028492743245824 |
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| author | Kyungreem Han Jinwoong Kim MooYoung Choi |
| author_facet | Kyungreem Han Jinwoong Kim MooYoung Choi |
| author_sort | Kyungreem Han |
| collection | DOAJ |
| description | Autophagy is a lysosomal degradation pathway, which is critical for maintaining normal cellular functions. Despite considerable advances in defining the specific molecular mechanism governing the autophagy pathway during the last decades, we are still far from understanding the underlying principle of the autophagy machinery and its complex role in human disease. As an alternative attempt to reinvigorate the search for the principle of the autophagy pathway, we in this study make use of the computer-aided analysis, complementing current molecular-level studies of autophagy. Specifically, we propose a hypothesis that autophagy mediates cellular phase transitions and demonstrate that the autophagic phase transitions are essential to the maintenance of normal cellular functions and critical in the fate of a cell, i.e., cell death or survival. This study should provide valuable insight into how interactions of sub-cellular components such as genes and protein modules/complexes regulate autophagy and then impact on the dynamic behaviors of living cells as a whole, bridging the microscopic molecular-level studies and the macroscopic cellular-level and physiological approaches. |
| first_indexed | 2024-12-10T05:04:40Z |
| format | Article |
| id | doaj.art-16b02ca0552c4239a85f322afd4388ef |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-10T05:04:40Z |
| publishDate | 2015-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-16b02ca0552c4239a85f322afd4388ef2022-12-22T02:01:17ZengElsevierHeliyon2405-84402015-09-011110.1016/j.heliyon.2015.e00027Autophagy mediates phase transitions from cell death to lifeKyungreem Han0Jinwoong Kim1MooYoung Choi2Department of Physics and Astronomy and Center for Theoretical Physics, Seoul National University, Seoul 151-747, South KoreaCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742, South KoreaDepartment of Physics and Astronomy and Center for Theoretical Physics, Seoul National University, Seoul 151-747, South KoreaAutophagy is a lysosomal degradation pathway, which is critical for maintaining normal cellular functions. Despite considerable advances in defining the specific molecular mechanism governing the autophagy pathway during the last decades, we are still far from understanding the underlying principle of the autophagy machinery and its complex role in human disease. As an alternative attempt to reinvigorate the search for the principle of the autophagy pathway, we in this study make use of the computer-aided analysis, complementing current molecular-level studies of autophagy. Specifically, we propose a hypothesis that autophagy mediates cellular phase transitions and demonstrate that the autophagic phase transitions are essential to the maintenance of normal cellular functions and critical in the fate of a cell, i.e., cell death or survival. This study should provide valuable insight into how interactions of sub-cellular components such as genes and protein modules/complexes regulate autophagy and then impact on the dynamic behaviors of living cells as a whole, bridging the microscopic molecular-level studies and the macroscopic cellular-level and physiological approaches.http://www.sciencedirect.com/science/article/pii/S2405844015302929AutophagyMathematical modelSimulationsPhase transitions |
| spellingShingle | Kyungreem Han Jinwoong Kim MooYoung Choi Autophagy mediates phase transitions from cell death to life Heliyon Autophagy Mathematical model Simulations Phase transitions |
| title | Autophagy mediates phase transitions from cell death to life |
| title_full | Autophagy mediates phase transitions from cell death to life |
| title_fullStr | Autophagy mediates phase transitions from cell death to life |
| title_full_unstemmed | Autophagy mediates phase transitions from cell death to life |
| title_short | Autophagy mediates phase transitions from cell death to life |
| title_sort | autophagy mediates phase transitions from cell death to life |
| topic | Autophagy Mathematical model Simulations Phase transitions |
| url | http://www.sciencedirect.com/science/article/pii/S2405844015302929 |
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