Ischemic stroke protected by ISO-1 inhibition of apoptosis via mitochondrial pathway

Ischemic stroke protected by ISO-1 inhibition of apoptosis via mitochondrial pathway

Abstract Macrophage migration inhibitory factor (MIF) is an immune mediator associated with inflammation, which is upregulated after ischemia in brain tissue. ISO-1 is a potent inhibitor of MIF tautomerase and can protect neurons by reducing the permeability of blood brain barrier (BBB). In this stu...

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Bibliographic Details
Main Authors:	Wanli Ji, Yaoxin Ren, Xiaolian Wei, Xiangxiang Ding, Yihan Dong, Bin Yuan
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-02-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-023-29907-z

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