Recent Insights into Clostridium perfringens Beta-Toxin
Clostridium perfringens beta-toxin is a key mediator of necrotizing enterocolitis and enterotoxemia. It is a pore-forming toxin (PFT) that exerts cytotoxic effect. Experimental investigation using piglet and rabbit intestinal loop models and a mouse infection model apparently showed that beta-toxin...
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MDPI AG
2015-02-01
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| Series: | Toxins |
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| Online Access: | http://www.mdpi.com/2072-6651/7/2/396 |
| _version_ | 1811301298533826560 |
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| author | Masahiro Nagahama Sadayuki Ochi Masataka Oda Kazuaki Miyamoto Masaya Takehara Keiko Kobayashi |
| author_facet | Masahiro Nagahama Sadayuki Ochi Masataka Oda Kazuaki Miyamoto Masaya Takehara Keiko Kobayashi |
| author_sort | Masahiro Nagahama |
| collection | DOAJ |
| description | Clostridium perfringens beta-toxin is a key mediator of necrotizing enterocolitis and enterotoxemia. It is a pore-forming toxin (PFT) that exerts cytotoxic effect. Experimental investigation using piglet and rabbit intestinal loop models and a mouse infection model apparently showed that beta-toxin is the important pathogenic factor of the organisms. The toxin caused the swelling and disruption of HL-60 cells and formed a functional pore in the lipid raft microdomains of sensitive cells. These findings represent significant progress in the characterization of the toxin with knowledge on its biological features, mechanism of action and structure-function having been accumulated. Our aims here are to review the current progresses in our comprehension of the virulence of C. perfringens type C and the character, biological feature and structure-function of beta-toxin. |
| first_indexed | 2024-04-13T07:06:13Z |
| format | Article |
| id | doaj.art-16b2225ea30241c28b62eb2dc9af1b86 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-13T07:06:13Z |
| publishDate | 2015-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-16b2225ea30241c28b62eb2dc9af1b862022-12-22T02:56:59ZengMDPI AGToxins2072-66512015-02-017239640610.3390/toxins7020396toxins7020396Recent Insights into Clostridium perfringens Beta-ToxinMasahiro Nagahama0Sadayuki Ochi1Masataka Oda2Kazuaki Miyamoto3Masaya Takehara4Keiko Kobayashi5Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho 770-8514, Tokushima, JapanDepartment of Microbiology, Fujita Health University School of Medicine, Toyoake 470-1192, Aichi, JapanDivision of Microbiology and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Gakkocho-dori, Chuo-ku 951-8514, Niigata, JapanDepartment of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho 770-8514, Tokushima, JapanDepartment of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho 770-8514, Tokushima, JapanDepartment of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho 770-8514, Tokushima, JapanClostridium perfringens beta-toxin is a key mediator of necrotizing enterocolitis and enterotoxemia. It is a pore-forming toxin (PFT) that exerts cytotoxic effect. Experimental investigation using piglet and rabbit intestinal loop models and a mouse infection model apparently showed that beta-toxin is the important pathogenic factor of the organisms. The toxin caused the swelling and disruption of HL-60 cells and formed a functional pore in the lipid raft microdomains of sensitive cells. These findings represent significant progress in the characterization of the toxin with knowledge on its biological features, mechanism of action and structure-function having been accumulated. Our aims here are to review the current progresses in our comprehension of the virulence of C. perfringens type C and the character, biological feature and structure-function of beta-toxin.http://www.mdpi.com/2072-6651/7/2/396Clostridium perfringens beta-toxinnecrotizing enterocolitispore-forming toxin |
| spellingShingle | Masahiro Nagahama Sadayuki Ochi Masataka Oda Kazuaki Miyamoto Masaya Takehara Keiko Kobayashi Recent Insights into Clostridium perfringens Beta-Toxin Toxins Clostridium perfringens beta-toxin necrotizing enterocolitis pore-forming toxin |
| title | Recent Insights into Clostridium perfringens Beta-Toxin |
| title_full | Recent Insights into Clostridium perfringens Beta-Toxin |
| title_fullStr | Recent Insights into Clostridium perfringens Beta-Toxin |
| title_full_unstemmed | Recent Insights into Clostridium perfringens Beta-Toxin |
| title_short | Recent Insights into Clostridium perfringens Beta-Toxin |
| title_sort | recent insights into clostridium perfringens beta toxin |
| topic | Clostridium perfringens beta-toxin necrotizing enterocolitis pore-forming toxin |
| url | http://www.mdpi.com/2072-6651/7/2/396 |
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