High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors

High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors

NK cell education is the process through which chronic engagement of inhibitory NK cell receptors by self MHC-I molecules preserves cellular responsiveness. The molecular mechanisms responsible for NK cell education remain unclear. Here, we show that mouse NK cell education is associated with a high...

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Bibliographic Details
Main Authors: Antoine Marçais, Marie Marotel, Sophie Degouve, Alice Koenig, Sébastien Fauteux-Daniel, Annabelle Drouillard, Heinrich Schlums, Sébastien Viel, Laurie Besson, Omran Allatif, Mathieu Bléry, Eric Vivier, Yenan Bryceson, Olivier Thaunat, Thierry Walzer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-09-01
Series:eLife
Subjects:
natural killer
cell signaling
mTOR
education
activation threshold
Online Access:https://elifesciences.org/articles/26423

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