Effect of fenofibrate and selective PPARα modulator (SPPARMα), pemafibrate on KATP channel activity and insulin secretion

Effect of fenofibrate and selective PPARα modulator (SPPARMα), pemafibrate on KATP channel activity and insulin secretion

Abstract Objective Insulin secretion is regulated by ATP-sensitive potassium (KATP) channels in pancreatic beta-cells. Peroxisome proliferator-activated receptors (PPAR) α ligands are clinically used to treat dyslipidemia. A PPARα ligand, fenofibrate, and PPARγ ligands troglitazone and 15-deoxy-∆12,...

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Bibliographic Details
Main Authors: Shigeki Kitamura, Naoya Murao, Shoko Yokota, Masaru Shimizu, Tomoyuki Ono, Yusuke Seino, Atsushi Suzuki, Yuko Maejima, Kenju Shimomura
Format: Article
Language:English
Published: BMC 2023-09-01
Series:BMC Research Notes
Subjects:
KATP channel
PPARα
fenofibrate
Pemafibrate
Online Access:https://doi.org/10.1186/s13104-023-06489-7

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