The Druze: a population genetic refugium of the Near East.
<h4>Background</h4>Phylogenetic mitochondrial DNA haplogroups are highly partitioned across global geographic regions. A unique exception is the X haplogroup, which has a widespread global distribution without major regions of distinct localization.<h4>Principal findings</h4>...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2008-05-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18461126/pdf/?tool=EBI |
| _version_ | 1818363147727142912 |
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| author | Liran I Shlush Doron M Behar Guennady Yudkovsky Alan Templeton Yarin Hadid Fuad Basis Michael Hammer Shalev Itzkovitz Karl Skorecki |
| author_facet | Liran I Shlush Doron M Behar Guennady Yudkovsky Alan Templeton Yarin Hadid Fuad Basis Michael Hammer Shalev Itzkovitz Karl Skorecki |
| author_sort | Liran I Shlush |
| collection | DOAJ |
| description | <h4>Background</h4>Phylogenetic mitochondrial DNA haplogroups are highly partitioned across global geographic regions. A unique exception is the X haplogroup, which has a widespread global distribution without major regions of distinct localization.<h4>Principal findings</h4>We have examined mitochondrial DNA sequence variation together with Y-chromosome-based haplogroup structure among the Druze, a religious minority with a unique socio-demographic history residing in the Near East. We observed a striking overall pattern of heterogeneous parental origins, consistent with Druze oral tradition, together with both a high frequency and a high diversity of the mitochondrial DNA (mtDNA) X haplogroup within a confined regional subpopulation. Furthermore demographic modeling indicated low migration rates with nearby populations.<h4>Conclusions</h4>These findings were enabled through the use of a paternal kindred based sampling approach, and suggest that the Galilee Druze represent a population isolate, and that the combination of a high frequency and diversity of the mtDNA X haplogroup signifies a phylogenetic refugium, providing a sample snapshot of the genetic landscape of the Near East prior to the modern age. |
| first_indexed | 2024-12-13T21:43:51Z |
| format | Article |
| id | doaj.art-16b72844ef9f4f4498c7d369efbefd17 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T21:43:51Z |
| publishDate | 2008-05-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-16b72844ef9f4f4498c7d369efbefd172022-12-21T23:30:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032008-05-0135e210510.1371/journal.pone.0002105The Druze: a population genetic refugium of the Near East.Liran I ShlushDoron M BeharGuennady YudkovskyAlan TempletonYarin HadidFuad BasisMichael HammerShalev ItzkovitzKarl Skorecki<h4>Background</h4>Phylogenetic mitochondrial DNA haplogroups are highly partitioned across global geographic regions. A unique exception is the X haplogroup, which has a widespread global distribution without major regions of distinct localization.<h4>Principal findings</h4>We have examined mitochondrial DNA sequence variation together with Y-chromosome-based haplogroup structure among the Druze, a religious minority with a unique socio-demographic history residing in the Near East. We observed a striking overall pattern of heterogeneous parental origins, consistent with Druze oral tradition, together with both a high frequency and a high diversity of the mitochondrial DNA (mtDNA) X haplogroup within a confined regional subpopulation. Furthermore demographic modeling indicated low migration rates with nearby populations.<h4>Conclusions</h4>These findings were enabled through the use of a paternal kindred based sampling approach, and suggest that the Galilee Druze represent a population isolate, and that the combination of a high frequency and diversity of the mtDNA X haplogroup signifies a phylogenetic refugium, providing a sample snapshot of the genetic landscape of the Near East prior to the modern age.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18461126/pdf/?tool=EBI |
| spellingShingle | Liran I Shlush Doron M Behar Guennady Yudkovsky Alan Templeton Yarin Hadid Fuad Basis Michael Hammer Shalev Itzkovitz Karl Skorecki The Druze: a population genetic refugium of the Near East. PLoS ONE |
| title | The Druze: a population genetic refugium of the Near East. |
| title_full | The Druze: a population genetic refugium of the Near East. |
| title_fullStr | The Druze: a population genetic refugium of the Near East. |
| title_full_unstemmed | The Druze: a population genetic refugium of the Near East. |
| title_short | The Druze: a population genetic refugium of the Near East. |
| title_sort | druze a population genetic refugium of the near east |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18461126/pdf/?tool=EBI |
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