RNAs as Regulators of Cellular Matchmaking
RNA molecules are increasingly being identified as facilitating or impeding the interaction of proteins and nucleic acids, serving as so-called scaffolds or decoys. Long non-coding RNAs have been commonly implicated in such roles, particularly in the regulation of nuclear processes including chromos...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2021.634146/full |
| _version_ | 1818952577964834816 |
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| author | Nikita Fernandes J. Ross Buchan |
| author_facet | Nikita Fernandes J. Ross Buchan |
| author_sort | Nikita Fernandes |
| collection | DOAJ |
| description | RNA molecules are increasingly being identified as facilitating or impeding the interaction of proteins and nucleic acids, serving as so-called scaffolds or decoys. Long non-coding RNAs have been commonly implicated in such roles, particularly in the regulation of nuclear processes including chromosome topology, regulation of chromatin state and gene transcription, and assembly of nuclear biomolecular condensates such as paraspeckles. Recently, an increased awareness of cytoplasmic RNA scaffolds and decoys has begun to emerge, including the identification of non-coding regions of mRNAs that can also function in a scaffold-like manner to regulate interactions of nascently translated proteins. Collectively, cytoplasmic RNA scaffolds and decoys are now implicated in processes such as mRNA translation, decay, protein localization, protein degradation and assembly of cytoplasmic biomolecular condensates such as P-bodies. Here, we review examples of RNA scaffolds and decoys in both the nucleus and cytoplasm, illustrating common themes, the suitability of RNA to such roles, and future challenges in identifying and better understanding RNA scaffolding and decoy functions. |
| first_indexed | 2024-12-20T09:52:36Z |
| format | Article |
| id | doaj.art-16b8190a6a684097aa274e6eb1a2bdff |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-20T09:52:36Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-16b8190a6a684097aa274e6eb1a2bdff2022-12-21T19:44:33ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2021-04-01810.3389/fmolb.2021.634146634146RNAs as Regulators of Cellular MatchmakingNikita FernandesJ. Ross BuchanRNA molecules are increasingly being identified as facilitating or impeding the interaction of proteins and nucleic acids, serving as so-called scaffolds or decoys. Long non-coding RNAs have been commonly implicated in such roles, particularly in the regulation of nuclear processes including chromosome topology, regulation of chromatin state and gene transcription, and assembly of nuclear biomolecular condensates such as paraspeckles. Recently, an increased awareness of cytoplasmic RNA scaffolds and decoys has begun to emerge, including the identification of non-coding regions of mRNAs that can also function in a scaffold-like manner to regulate interactions of nascently translated proteins. Collectively, cytoplasmic RNA scaffolds and decoys are now implicated in processes such as mRNA translation, decay, protein localization, protein degradation and assembly of cytoplasmic biomolecular condensates such as P-bodies. Here, we review examples of RNA scaffolds and decoys in both the nucleus and cytoplasm, illustrating common themes, the suitability of RNA to such roles, and future challenges in identifying and better understanding RNA scaffolding and decoy functions.https://www.frontiersin.org/articles/10.3389/fmolb.2021.634146/fullRNA scaffoldsRNA decoys3′UTRnascent protein interactionslncRNAmRNA |
| spellingShingle | Nikita Fernandes J. Ross Buchan RNAs as Regulators of Cellular Matchmaking Frontiers in Molecular Biosciences RNA scaffolds RNA decoys 3′UTR nascent protein interactions lncRNA mRNA |
| title | RNAs as Regulators of Cellular Matchmaking |
| title_full | RNAs as Regulators of Cellular Matchmaking |
| title_fullStr | RNAs as Regulators of Cellular Matchmaking |
| title_full_unstemmed | RNAs as Regulators of Cellular Matchmaking |
| title_short | RNAs as Regulators of Cellular Matchmaking |
| title_sort | rnas as regulators of cellular matchmaking |
| topic | RNA scaffolds RNA decoys 3′UTR nascent protein interactions lncRNA mRNA |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2021.634146/full |
| work_keys_str_mv | AT nikitafernandes rnasasregulatorsofcellularmatchmaking AT jrossbuchan rnasasregulatorsofcellularmatchmaking |