Correlation between atherogenic index of plasma and coronary artery disease in males of different ages: a retrospective study
Abstract Background Atherogenic index of plasma (AIP) as a newly discovered blood lipid parameter was shown to be strongly correlated with coronary artery disease (CAD). However, the blood lipid levels changed with age, so we speculated that the correlation between AIP and CAD was also affected by a...
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-022-02877-2 |
| _version_ | 1811182341446434816 |
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| author | Lei Hong Yu Han Chunfeng Deng Aihua Chen |
| author_facet | Lei Hong Yu Han Chunfeng Deng Aihua Chen |
| author_sort | Lei Hong |
| collection | DOAJ |
| description | Abstract Background Atherogenic index of plasma (AIP) as a newly discovered blood lipid parameter was shown to be strongly correlated with coronary artery disease (CAD). However, the blood lipid levels changed with age, so we speculated that the correlation between AIP and CAD was also affected by age. Methods A retrospective study was performed on male patients with confirmed or suspected CAD who underwent coronary angiography (CAG) from July 2017 to March 2021. Patients were divided into younger, middle early, middle late, and elderly groups. Patients in each age group were further divided into the non-coronary artery disease (n-CAD) and CAD subgroups according to the CAG diagnostic results. The relationship between blood lipid parameters and CAD was assessed in each age group. Results Age-dependent changes of blood lipid levels were mainly found in CAD patients but not in n-CAD patients. With increased age, the levels of triglyceride, total cholesterol, low-density lipoprotein cholesterol (LDL-C) and AIP were gradually decreased, whereas high-density lipoprotein cholesterol concentration was increased in CAD patients. Multivariate logistic regression analyses showed that AIP was an independent risk factor for CAD in middle early (OR 2.601; CI 1.160–5.832, P = 0.02) and middle late age group (OR 2.707, CI 1.201–6.100, P = 0.016), but not in the younger and elderly groups. LDL-C was an independent risk factor for CAD in all age groups. The areas under curve of AIP for detecting CAD in the middle early and middle late age groups were not higher than that of other blood lipid parameters. Conclusion Although this was a single-center study for males only, the correlation between AIP level and CAD risk was age-dependent. AIP was an independent risk factor for CAD in the middle-aged groups. However, the predictive value of AIP for detecting CAD was not better than that of the traditional blood lipid parameters such as LDL-C. |
| first_indexed | 2024-04-11T09:29:45Z |
| format | Article |
| id | doaj.art-16b8273743d74200ba5d7bf8bca11928 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-04-11T09:29:45Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-16b8273743d74200ba5d7bf8bca119282022-12-22T04:31:54ZengBMCBMC Cardiovascular Disorders1471-22612022-10-0122111010.1186/s12872-022-02877-2Correlation between atherogenic index of plasma and coronary artery disease in males of different ages: a retrospective studyLei Hong0Yu Han1Chunfeng Deng2Aihua Chen3Department of Cardiology, Heart Center, Zhujiang Hospital, Southern Medical UniversityCentre for Human and Applied Physiological Sciences, Faculty of Life Sciences and Medicine, King’s College LondonDepartment of Nephrology, Longgang Central HospitalDepartment of Cardiology, Heart Center, Zhujiang Hospital, Southern Medical UniversityAbstract Background Atherogenic index of plasma (AIP) as a newly discovered blood lipid parameter was shown to be strongly correlated with coronary artery disease (CAD). However, the blood lipid levels changed with age, so we speculated that the correlation between AIP and CAD was also affected by age. Methods A retrospective study was performed on male patients with confirmed or suspected CAD who underwent coronary angiography (CAG) from July 2017 to March 2021. Patients were divided into younger, middle early, middle late, and elderly groups. Patients in each age group were further divided into the non-coronary artery disease (n-CAD) and CAD subgroups according to the CAG diagnostic results. The relationship between blood lipid parameters and CAD was assessed in each age group. Results Age-dependent changes of blood lipid levels were mainly found in CAD patients but not in n-CAD patients. With increased age, the levels of triglyceride, total cholesterol, low-density lipoprotein cholesterol (LDL-C) and AIP were gradually decreased, whereas high-density lipoprotein cholesterol concentration was increased in CAD patients. Multivariate logistic regression analyses showed that AIP was an independent risk factor for CAD in middle early (OR 2.601; CI 1.160–5.832, P = 0.02) and middle late age group (OR 2.707, CI 1.201–6.100, P = 0.016), but not in the younger and elderly groups. LDL-C was an independent risk factor for CAD in all age groups. The areas under curve of AIP for detecting CAD in the middle early and middle late age groups were not higher than that of other blood lipid parameters. Conclusion Although this was a single-center study for males only, the correlation between AIP level and CAD risk was age-dependent. AIP was an independent risk factor for CAD in the middle-aged groups. However, the predictive value of AIP for detecting CAD was not better than that of the traditional blood lipid parameters such as LDL-C.https://doi.org/10.1186/s12872-022-02877-2Coronary artery diseaseAtherogenic index of plasmaAge |
| spellingShingle | Lei Hong Yu Han Chunfeng Deng Aihua Chen Correlation between atherogenic index of plasma and coronary artery disease in males of different ages: a retrospective study BMC Cardiovascular Disorders Coronary artery disease Atherogenic index of plasma Age |
| title | Correlation between atherogenic index of plasma and coronary artery disease in males of different ages: a retrospective study |
| title_full | Correlation between atherogenic index of plasma and coronary artery disease in males of different ages: a retrospective study |
| title_fullStr | Correlation between atherogenic index of plasma and coronary artery disease in males of different ages: a retrospective study |
| title_full_unstemmed | Correlation between atherogenic index of plasma and coronary artery disease in males of different ages: a retrospective study |
| title_short | Correlation between atherogenic index of plasma and coronary artery disease in males of different ages: a retrospective study |
| title_sort | correlation between atherogenic index of plasma and coronary artery disease in males of different ages a retrospective study |
| topic | Coronary artery disease Atherogenic index of plasma Age |
| url | https://doi.org/10.1186/s12872-022-02877-2 |
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