Extracellular matrix-derived materials for tissue engineering and regenerative medicine: A journey from isolation to characterization and application
Biomaterial choice is an essential step during the development tissue engineering and regenerative medicine (TERM) applications. The selected biomaterial must present properties allowing the physiological-like recapitulation of several processes that lead to the reestablishment of homeostatic tissue...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-04-01
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| Series: | Bioactive Materials |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X24000045 |
| _version_ | 1797324313606488064 |
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| author | Helena Vilaça-Faria Jennifer Noro Rui L. Reis Rogério P. Pirraco |
| author_facet | Helena Vilaça-Faria Jennifer Noro Rui L. Reis Rogério P. Pirraco |
| author_sort | Helena Vilaça-Faria |
| collection | DOAJ |
| description | Biomaterial choice is an essential step during the development tissue engineering and regenerative medicine (TERM) applications. The selected biomaterial must present properties allowing the physiological-like recapitulation of several processes that lead to the reestablishment of homeostatic tissue or organ function. Biomaterials derived from the extracellular matrix (ECM) present many such properties and their use in the field has been steadily increasing. Considering this growing importance, it becomes imperative to provide a comprehensive overview of ECM biomaterials, encompassing their sourcing, processing, and integration into TERM applications. This review compiles the main strategies used to isolate and process ECM-derived biomaterials as well as different techniques used for its characterization, namely biochemical and chemical, physical, morphological, and biological. Lastly, some of their applications in the TERM field are explored and discussed. |
| first_indexed | 2024-03-08T05:54:16Z |
| format | Article |
| id | doaj.art-16b8430aa2404ef0a9c1c5fd415c08f0 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-03-08T05:54:16Z |
| publishDate | 2024-04-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-16b8430aa2404ef0a9c1c5fd415c08f02024-02-05T04:32:05ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2024-04-0134494519Extracellular matrix-derived materials for tissue engineering and regenerative medicine: A journey from isolation to characterization and applicationHelena Vilaça-Faria0Jennifer Noro1Rui L. Reis2Rogério P. Pirraco33B's Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017, Barco, Guimarães, Portugal; ICVS/3B's – PT Government Associate Laboratory, Braga, Guimarães, Portugal3B's Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017, Barco, Guimarães, Portugal; ICVS/3B's – PT Government Associate Laboratory, Braga, Guimarães, Portugal3B's Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017, Barco, Guimarães, Portugal; ICVS/3B's – PT Government Associate Laboratory, Braga, Guimarães, Portugal3B's Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017, Barco, Guimarães, Portugal; ICVS/3B's – PT Government Associate Laboratory, Braga, Guimarães, Portugal; Corresponding author. 3B's Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017, Barco, Guimarães, Portugal.Biomaterial choice is an essential step during the development tissue engineering and regenerative medicine (TERM) applications. The selected biomaterial must present properties allowing the physiological-like recapitulation of several processes that lead to the reestablishment of homeostatic tissue or organ function. Biomaterials derived from the extracellular matrix (ECM) present many such properties and their use in the field has been steadily increasing. Considering this growing importance, it becomes imperative to provide a comprehensive overview of ECM biomaterials, encompassing their sourcing, processing, and integration into TERM applications. This review compiles the main strategies used to isolate and process ECM-derived biomaterials as well as different techniques used for its characterization, namely biochemical and chemical, physical, morphological, and biological. Lastly, some of their applications in the TERM field are explored and discussed.http://www.sciencedirect.com/science/article/pii/S2452199X24000045Extracted ECMExtraction methodsCharacterizationECM-derived applications |
| spellingShingle | Helena Vilaça-Faria Jennifer Noro Rui L. Reis Rogério P. Pirraco Extracellular matrix-derived materials for tissue engineering and regenerative medicine: A journey from isolation to characterization and application Bioactive Materials Extracted ECM Extraction methods Characterization ECM-derived applications |
| title | Extracellular matrix-derived materials for tissue engineering and regenerative medicine: A journey from isolation to characterization and application |
| title_full | Extracellular matrix-derived materials for tissue engineering and regenerative medicine: A journey from isolation to characterization and application |
| title_fullStr | Extracellular matrix-derived materials for tissue engineering and regenerative medicine: A journey from isolation to characterization and application |
| title_full_unstemmed | Extracellular matrix-derived materials for tissue engineering and regenerative medicine: A journey from isolation to characterization and application |
| title_short | Extracellular matrix-derived materials for tissue engineering and regenerative medicine: A journey from isolation to characterization and application |
| title_sort | extracellular matrix derived materials for tissue engineering and regenerative medicine a journey from isolation to characterization and application |
| topic | Extracted ECM Extraction methods Characterization ECM-derived applications |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X24000045 |
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