Acanthosis nigricans in a patient with metastatic insulinoma post peptide receptor radionuclide therapy
Acanthosis nigricans (AN) is a common dermatosis associated with hyperinsulinemia and insulin resistance. However, AN has been rarely reported in patients with insulinoma, a state of persistent hyperinsulinemia. We present a case of metastatic insulinoma, in whom AN manifested after the first cycle...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Bioscientifica
2022-06-01
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| Series: | Endocrinology, Diabetes & Metabolism Case Reports |
| Online Access: | https://edm.bioscientifica.com/view/journals/edm/2022/1/EDM21-0150.xml |
| _version_ | 1818253878365257728 |
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| author | Jenny S W Yun Chris McCormack Michelle Goh Cherie Chiang |
| author_facet | Jenny S W Yun Chris McCormack Michelle Goh Cherie Chiang |
| author_sort | Jenny S W Yun |
| collection | DOAJ |
| description | Acanthosis nigricans (AN) is a common dermatosis associated with hyperinsulinemia and insulin resistance. However, AN has been rarely reported in patients with insulinoma, a state of persistent hyperinsulinemia. We present a case of metastatic insulinoma, in whom AN manifested after the first cycle of peptide receptor radionuclide therapy (PRRT). A 40-year-old man was diagnosed with metastatic insulinoma after 5 months of symptomatic hypoglycemia. Within 1 month post PRRT, the patient became euglycemic but developed a pigmented, pruritic rash which was confirmed on biopsy as AN. We discuss the rare manifestation of AN in subjects with insulinoma, the role of insulin in the pathogenesis of AN, malignant AN in non-insulin-secreting malignancies and association with other insulin-resistant endocrinopathies such as acromegaly. |
| first_indexed | 2024-12-12T16:47:04Z |
| format | Article |
| id | doaj.art-16bdb09806044e9e89cb8a2a9c78a6f7 |
| institution | Directory Open Access Journal |
| issn | 2052-0573 |
| language | English |
| last_indexed | 2024-12-12T16:47:04Z |
| publishDate | 2022-06-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrinology, Diabetes & Metabolism Case Reports |
| spelling | doaj.art-16bdb09806044e9e89cb8a2a9c78a6f72022-12-22T00:18:26ZengBioscientificaEndocrinology, Diabetes & Metabolism Case Reports2052-05732022-06-01111510.1530/EDM-21-0150Acanthosis nigricans in a patient with metastatic insulinoma post peptide receptor radionuclide therapyJenny S W Yun0Chris McCormack1Michelle Goh2Cherie Chiang3Department of Surgical OncologyDepartment of Surgical OncologyDepartment of Surgical OncologyDepartment of Internal Medicine, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; University of Melbourne, Parkville, Victoria, AustraliaAcanthosis nigricans (AN) is a common dermatosis associated with hyperinsulinemia and insulin resistance. However, AN has been rarely reported in patients with insulinoma, a state of persistent hyperinsulinemia. We present a case of metastatic insulinoma, in whom AN manifested after the first cycle of peptide receptor radionuclide therapy (PRRT). A 40-year-old man was diagnosed with metastatic insulinoma after 5 months of symptomatic hypoglycemia. Within 1 month post PRRT, the patient became euglycemic but developed a pigmented, pruritic rash which was confirmed on biopsy as AN. We discuss the rare manifestation of AN in subjects with insulinoma, the role of insulin in the pathogenesis of AN, malignant AN in non-insulin-secreting malignancies and association with other insulin-resistant endocrinopathies such as acromegaly.https://edm.bioscientifica.com/view/journals/edm/2022/1/EDM21-0150.xml |
| spellingShingle | Jenny S W Yun Chris McCormack Michelle Goh Cherie Chiang Acanthosis nigricans in a patient with metastatic insulinoma post peptide receptor radionuclide therapy Endocrinology, Diabetes & Metabolism Case Reports |
| title | Acanthosis nigricans in a patient with metastatic insulinoma post peptide receptor radionuclide therapy |
| title_full | Acanthosis nigricans in a patient with metastatic insulinoma post peptide receptor radionuclide therapy |
| title_fullStr | Acanthosis nigricans in a patient with metastatic insulinoma post peptide receptor radionuclide therapy |
| title_full_unstemmed | Acanthosis nigricans in a patient with metastatic insulinoma post peptide receptor radionuclide therapy |
| title_short | Acanthosis nigricans in a patient with metastatic insulinoma post peptide receptor radionuclide therapy |
| title_sort | acanthosis nigricans in a patient with metastatic insulinoma post peptide receptor radionuclide therapy |
| url | https://edm.bioscientifica.com/view/journals/edm/2022/1/EDM21-0150.xml |
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