Monocyte/Lymphocyte Ratio and MCHC as Predictors of Collateral Carotid Artery Disease—Preliminary Report
Background: Carotid artery disease accounts for 30% of ischemic strokes in the general population. Numerous biomarkers have been investigated for predicting either the progression or the severity of the disease. The aim of this retrospective study was to compare hematologic indices among patients re...
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| Format: | Article |
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MDPI AG
2021-12-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/11/12/1266 |
| _version_ | 1797503159244947456 |
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| author | Tomasz Urbanowicz Michał Michalak Anna Olasińska-Wiśniewska Michał Rodzki Aleksandra Krasińska Bartłomiej Perek Zbigniew Krasiński Marek Jemielity |
| author_facet | Tomasz Urbanowicz Michał Michalak Anna Olasińska-Wiśniewska Michał Rodzki Aleksandra Krasińska Bartłomiej Perek Zbigniew Krasiński Marek Jemielity |
| author_sort | Tomasz Urbanowicz |
| collection | DOAJ |
| description | Background: Carotid artery disease accounts for 30% of ischemic strokes in the general population. Numerous biomarkers have been investigated for predicting either the progression or the severity of the disease. The aim of this retrospective study was to compare hematologic indices among patients referred for surgical interventions due to severe carotid disease. Methods: In total, 135 patients (87 (64.4%) men and 48 (35.6%) women) with a mean age of 70 ± 8 years who underwent surgical carotid intervention were enrolled into the study. Results: A Mann–Whitney test for independent samples revealed significant differences in monocyte to lymphocyte ratio (MLR) and mean corpuscular hemoglobin concentration (MCHC) between patients with one and two (collateral) carotid diseases. The cut-off value for MLR was 0.3 (AUC = 0.654, <i>p</i> = 0.048, 70.0% sensitivity and 74.6% specificity) and for MHCH was 21.6. (AUC = 0.730, <i>p</i> < 0.001, 70.0% sensitivity and 77.2% specificity). A multivariable model of logistic regression revealed two significant parameters for collateral carotid stenosis disease including MLR > 0.3 (OR 6.19 with 95% CI 2.02–19.01, <i>p</i> = 0.001) and MCHC > 21.6 (OR 7.76, 95% CI 2.54–23.72, <i>p</i> < 0.001). Conclusions: MLR above 0.3 and MCHC above 21.6 have predictive values for colleterial carotid stenosis and may be used as easily accessible indicators for atherosclerosis severity. |
| first_indexed | 2024-03-10T03:46:32Z |
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| id | doaj.art-16beef4641054247996dfbb7c8835429 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T03:46:32Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-16beef4641054247996dfbb7c88354292023-11-23T09:07:06ZengMDPI AGJournal of Personalized Medicine2075-44262021-12-011112126610.3390/jpm11121266Monocyte/Lymphocyte Ratio and MCHC as Predictors of Collateral Carotid Artery Disease—Preliminary ReportTomasz Urbanowicz0Michał Michalak1Anna Olasińska-Wiśniewska2Michał Rodzki3Aleksandra Krasińska4Bartłomiej Perek5Zbigniew Krasiński6Marek Jemielity7Cardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, PolandDepartment of Computer Science and Statistics, Poznan University of Medical Sciences, 61-848 Poznan, PolandCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, PolandCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, PolandDepartment of Ophtalmology, Poznan University of Medical Sciences, 61-848 Poznan, PolandCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, PolandDepartment of Vascular, Endovascular Surgery, Poznan University of Medical Science, 61-848 Poznan, PolandCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, PolandBackground: Carotid artery disease accounts for 30% of ischemic strokes in the general population. Numerous biomarkers have been investigated for predicting either the progression or the severity of the disease. The aim of this retrospective study was to compare hematologic indices among patients referred for surgical interventions due to severe carotid disease. Methods: In total, 135 patients (87 (64.4%) men and 48 (35.6%) women) with a mean age of 70 ± 8 years who underwent surgical carotid intervention were enrolled into the study. Results: A Mann–Whitney test for independent samples revealed significant differences in monocyte to lymphocyte ratio (MLR) and mean corpuscular hemoglobin concentration (MCHC) between patients with one and two (collateral) carotid diseases. The cut-off value for MLR was 0.3 (AUC = 0.654, <i>p</i> = 0.048, 70.0% sensitivity and 74.6% specificity) and for MHCH was 21.6. (AUC = 0.730, <i>p</i> < 0.001, 70.0% sensitivity and 77.2% specificity). A multivariable model of logistic regression revealed two significant parameters for collateral carotid stenosis disease including MLR > 0.3 (OR 6.19 with 95% CI 2.02–19.01, <i>p</i> = 0.001) and MCHC > 21.6 (OR 7.76, 95% CI 2.54–23.72, <i>p</i> < 0.001). Conclusions: MLR above 0.3 and MCHC above 21.6 have predictive values for colleterial carotid stenosis and may be used as easily accessible indicators for atherosclerosis severity.https://www.mdpi.com/2075-4426/11/12/1266MLR 1MCHC 2carotid stenosis 3 |
| spellingShingle | Tomasz Urbanowicz Michał Michalak Anna Olasińska-Wiśniewska Michał Rodzki Aleksandra Krasińska Bartłomiej Perek Zbigniew Krasiński Marek Jemielity Monocyte/Lymphocyte Ratio and MCHC as Predictors of Collateral Carotid Artery Disease—Preliminary Report Journal of Personalized Medicine MLR 1 MCHC 2 carotid stenosis 3 |
| title | Monocyte/Lymphocyte Ratio and MCHC as Predictors of Collateral Carotid Artery Disease—Preliminary Report |
| title_full | Monocyte/Lymphocyte Ratio and MCHC as Predictors of Collateral Carotid Artery Disease—Preliminary Report |
| title_fullStr | Monocyte/Lymphocyte Ratio and MCHC as Predictors of Collateral Carotid Artery Disease—Preliminary Report |
| title_full_unstemmed | Monocyte/Lymphocyte Ratio and MCHC as Predictors of Collateral Carotid Artery Disease—Preliminary Report |
| title_short | Monocyte/Lymphocyte Ratio and MCHC as Predictors of Collateral Carotid Artery Disease—Preliminary Report |
| title_sort | monocyte lymphocyte ratio and mchc as predictors of collateral carotid artery disease preliminary report |
| topic | MLR 1 MCHC 2 carotid stenosis 3 |
| url | https://www.mdpi.com/2075-4426/11/12/1266 |
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