Destabilization of the medial meniscus to induce post-traumatic osteoarthritis in domestic pigs
Introduction: Post-traumatic osteoarthritis (PTOA) develops following traumatic articular insult. One model system used to study the progression and treatment of PTOA is the destabilization of the medial meniscus (DMM) as first described by Glasson et al performed in mini-pigs. Miniature pigs are le...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Journal of Cartilage & Joint Preservation |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667254523000458 |
| _version_ | 1797398396482355200 |
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| author | Jacqueline M. Chevalier Garett B. Pearson Nicole Nixon Carl R. Flannery Luis Campoy Lisa A. Fortier |
| author_facet | Jacqueline M. Chevalier Garett B. Pearson Nicole Nixon Carl R. Flannery Luis Campoy Lisa A. Fortier |
| author_sort | Jacqueline M. Chevalier |
| collection | DOAJ |
| description | Introduction: Post-traumatic osteoarthritis (PTOA) develops following traumatic articular insult. One model system used to study the progression and treatment of PTOA is the destabilization of the medial meniscus (DMM) as first described by Glasson et al performed in mini-pigs. Miniature pigs are less available, more expensive, and have synovial fluid sampling limitations, limiting the availability of osteoarthritis biomarkers compared to domestic pigs. Objectives: The following technical note details stepwise procedures and animal welfare strategies for the use of Yorkshire pigs as a large animal PTOA model. Methods: The following technical note details stepwise procedures to perform peroperative saphenous nerve block, DMM, and subsequent postoperative management in Yorkshire pigs as a large animal PTOA model. Results: At 4 weeks post-operatively, all pigs develop mild-moderate PTOA based on postmortem joint dissections. Conclusions: This technical note provides further details on the arthrotomy approach to destabilize the medial meniscus of domestic pigs as a model of PTOA. |
| first_indexed | 2024-03-09T01:25:04Z |
| format | Article |
| id | doaj.art-16bf0f70856b45e98d5e498be7f84627 |
| institution | Directory Open Access Journal |
| issn | 2667-2545 |
| language | English |
| last_indexed | 2024-03-09T01:25:04Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Cartilage & Joint Preservation |
| spelling | doaj.art-16bf0f70856b45e98d5e498be7f846272023-12-10T06:18:56ZengElsevierJournal of Cartilage & Joint Preservation2667-25452023-12-0134100139Destabilization of the medial meniscus to induce post-traumatic osteoarthritis in domestic pigsJacqueline M. Chevalier0Garett B. Pearson1Nicole Nixon2Carl R. Flannery3Luis Campoy4Lisa A. Fortier5Department of Clinical Sciences, Cornell University, Ithaca, NY, USADepartment of Clinical Sciences, Cornell University, Ithaca, NY, USADepartment of Clinical Sciences, Cornell University, Ithaca, NY, USAScientific Affairs, Bioventus, Durham, NC, USADepartment of Clinical Sciences, Cornell University, Ithaca, NY, USADepartment of Clinical Sciences, Cornell University, Ithaca, NY, USA; Lisa A. Fortier, Cornell University, 930 Campus Rd, Ithaca, NY 14853.Introduction: Post-traumatic osteoarthritis (PTOA) develops following traumatic articular insult. One model system used to study the progression and treatment of PTOA is the destabilization of the medial meniscus (DMM) as first described by Glasson et al performed in mini-pigs. Miniature pigs are less available, more expensive, and have synovial fluid sampling limitations, limiting the availability of osteoarthritis biomarkers compared to domestic pigs. Objectives: The following technical note details stepwise procedures and animal welfare strategies for the use of Yorkshire pigs as a large animal PTOA model. Methods: The following technical note details stepwise procedures to perform peroperative saphenous nerve block, DMM, and subsequent postoperative management in Yorkshire pigs as a large animal PTOA model. Results: At 4 weeks post-operatively, all pigs develop mild-moderate PTOA based on postmortem joint dissections. Conclusions: This technical note provides further details on the arthrotomy approach to destabilize the medial meniscus of domestic pigs as a model of PTOA.http://www.sciencedirect.com/science/article/pii/S2667254523000458Destabilization of the medial meniscusNerve blockPigsPost-traumatic osteoarthritisTranslational model |
| spellingShingle | Jacqueline M. Chevalier Garett B. Pearson Nicole Nixon Carl R. Flannery Luis Campoy Lisa A. Fortier Destabilization of the medial meniscus to induce post-traumatic osteoarthritis in domestic pigs Journal of Cartilage & Joint Preservation Destabilization of the medial meniscus Nerve block Pigs Post-traumatic osteoarthritis Translational model |
| title | Destabilization of the medial meniscus to induce post-traumatic osteoarthritis in domestic pigs |
| title_full | Destabilization of the medial meniscus to induce post-traumatic osteoarthritis in domestic pigs |
| title_fullStr | Destabilization of the medial meniscus to induce post-traumatic osteoarthritis in domestic pigs |
| title_full_unstemmed | Destabilization of the medial meniscus to induce post-traumatic osteoarthritis in domestic pigs |
| title_short | Destabilization of the medial meniscus to induce post-traumatic osteoarthritis in domestic pigs |
| title_sort | destabilization of the medial meniscus to induce post traumatic osteoarthritis in domestic pigs |
| topic | Destabilization of the medial meniscus Nerve block Pigs Post-traumatic osteoarthritis Translational model |
| url | http://www.sciencedirect.com/science/article/pii/S2667254523000458 |
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