Ectodermal disturbance in development shared by anorexia and schizophrenia may reflect neurodevelopmental abnormalities
Abstract Minor physical abnormalities (MPA) are subtle dysmorphic features of bodily structures that have little or no impact on function. Most MPA develop during the first gestational trimester and are considered as important indicators of neuroectodermal deficiencies emerging during early brain de...
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| Format: | Article |
| Language: | English |
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Wiley
2021-10-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.2281 |
| _version_ | 1818741862164332544 |
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| author | Barbara Remberk Piotr Niwiński Ewa Brzóska‐Konkol Anna Borowska Anna Papasz‐Siemieniuk Joanna Brągoszewska Anna Katarzyna Bażyńska Łukasz Szostakiewicz Anna Herman |
| author_facet | Barbara Remberk Piotr Niwiński Ewa Brzóska‐Konkol Anna Borowska Anna Papasz‐Siemieniuk Joanna Brągoszewska Anna Katarzyna Bażyńska Łukasz Szostakiewicz Anna Herman |
| author_sort | Barbara Remberk |
| collection | DOAJ |
| description | Abstract Minor physical abnormalities (MPA) are subtle dysmorphic features of bodily structures that have little or no impact on function. Most MPA develop during the first gestational trimester and are considered as important indicators of neuroectodermal deficiencies emerging during early brain development. A higher frequency of MPA was confirmed in schizophrenia patients and their relatives, when compared to controls. These findings are consistent with the neurodevelopmental model of schizophrenia. A neurodevelopmental component amongst other risk factors has also been recently proposed for anorexia nervosa (AN). The current study aimed to assess MPA frequency in adolescent inpatients with either schizophrenia spectrum disorders (SSD) or AN as compared to healthy controls (HC). The Waldrop Scale was used for assessing MPA. The mean MPA total score and mean head subscore was significantly higher in both test groups than in HC. There were no statistically significant differences between SSD and AN groups. The MPA profile (not frequency) was similar in all three groups. This finding is consistent both with widely acknowledged neurodevelopmental schizophrenia hypothesis as well as with more recent neurodevelopmental model of AN. Nevertheless, the findings should not be overgeneralized and further studies are warranted. |
| first_indexed | 2024-12-18T02:03:22Z |
| format | Article |
| id | doaj.art-16c05693013c44c6914549bf1bdcdb28 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-12-18T02:03:22Z |
| publishDate | 2021-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-16c05693013c44c6914549bf1bdcdb282022-12-21T21:24:40ZengWileyBrain and Behavior2162-32792021-10-011110n/an/a10.1002/brb3.2281Ectodermal disturbance in development shared by anorexia and schizophrenia may reflect neurodevelopmental abnormalitiesBarbara Remberk0Piotr Niwiński1Ewa Brzóska‐Konkol2Anna Borowska3Anna Papasz‐Siemieniuk4Joanna Brągoszewska5Anna Katarzyna Bażyńska6Łukasz Szostakiewicz7Anna Herman8Institute of Psychiatry and Neurology Warsaw PolandPsychological and Pedagogical Counselling Centre no 7 Warsaw PolandInstitute of Psychiatry and Neurology Warsaw PolandInstitute of Psychiatry and Neurology Warsaw PolandInstitute of Psychiatry and Neurology Warsaw PolandInstitute of Psychiatry and Neurology Warsaw PolandInstitute of Psychiatry and Neurology Warsaw PolandInstitute of Psychiatry and Neurology Warsaw PolandMedical University of Warsaw Warsaw PolandAbstract Minor physical abnormalities (MPA) are subtle dysmorphic features of bodily structures that have little or no impact on function. Most MPA develop during the first gestational trimester and are considered as important indicators of neuroectodermal deficiencies emerging during early brain development. A higher frequency of MPA was confirmed in schizophrenia patients and their relatives, when compared to controls. These findings are consistent with the neurodevelopmental model of schizophrenia. A neurodevelopmental component amongst other risk factors has also been recently proposed for anorexia nervosa (AN). The current study aimed to assess MPA frequency in adolescent inpatients with either schizophrenia spectrum disorders (SSD) or AN as compared to healthy controls (HC). The Waldrop Scale was used for assessing MPA. The mean MPA total score and mean head subscore was significantly higher in both test groups than in HC. There were no statistically significant differences between SSD and AN groups. The MPA profile (not frequency) was similar in all three groups. This finding is consistent both with widely acknowledged neurodevelopmental schizophrenia hypothesis as well as with more recent neurodevelopmental model of AN. Nevertheless, the findings should not be overgeneralized and further studies are warranted.https://doi.org/10.1002/brb3.2281adolescentanorexiaminor physical abnormalitiesneurodevelopmentschizophrenia |
| spellingShingle | Barbara Remberk Piotr Niwiński Ewa Brzóska‐Konkol Anna Borowska Anna Papasz‐Siemieniuk Joanna Brągoszewska Anna Katarzyna Bażyńska Łukasz Szostakiewicz Anna Herman Ectodermal disturbance in development shared by anorexia and schizophrenia may reflect neurodevelopmental abnormalities Brain and Behavior adolescent anorexia minor physical abnormalities neurodevelopment schizophrenia |
| title | Ectodermal disturbance in development shared by anorexia and schizophrenia may reflect neurodevelopmental abnormalities |
| title_full | Ectodermal disturbance in development shared by anorexia and schizophrenia may reflect neurodevelopmental abnormalities |
| title_fullStr | Ectodermal disturbance in development shared by anorexia and schizophrenia may reflect neurodevelopmental abnormalities |
| title_full_unstemmed | Ectodermal disturbance in development shared by anorexia and schizophrenia may reflect neurodevelopmental abnormalities |
| title_short | Ectodermal disturbance in development shared by anorexia and schizophrenia may reflect neurodevelopmental abnormalities |
| title_sort | ectodermal disturbance in development shared by anorexia and schizophrenia may reflect neurodevelopmental abnormalities |
| topic | adolescent anorexia minor physical abnormalities neurodevelopment schizophrenia |
| url | https://doi.org/10.1002/brb3.2281 |
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