Alternative Lengthening of Telomeres Is Rare in Canine Histiocytic Sarcoma

Alternative Lengthening of Telomeres Is Rare in Canine Histiocytic Sarcoma

Cancer cells activate telomere maintenance mechanisms (TMMs) to overcome senescence and thus are targets for TMM-specific therapies. Telomerase-independent alternative lengthening of telomeres (ALT) is frequently utilized as a TMM in human sarcoma subtypes. Histiocytic sarcoma (HS) is a rare but agg...

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Bibliographic Details
Main Authors: Theresa Kreilmeier-Berger, Heike Aupperle-Lellbach, Martin Reifinger, Nicolai Valentin Hörstke, Klaus Holzmann, Miriam Kleiter
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Cancers
Subjects:
C-circle assay
telomere
prevalence study
orphan tumor
Online Access:https://www.mdpi.com/2072-6694/15/17/4214

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