Whole-exome sequencing expands the roles of novel mutations of organic anion transporting polypeptide, ATP-binding cassette transporter, and receptor genes in intrahepatic cholestasis of pregnancy

Whole-exome sequencing expands the roles of novel mutations of organic anion transporting polypeptide, ATP-binding cassette transporter, and receptor genes in intrahepatic cholestasis of pregnancy

Background: Intrahepatic cholestasis of pregnancy (ICP) is associated with a high incidence of fetal morbidity and mortality. Therefore, revealing the mechanisms involved in ICP and its association with fetal complications is very important.Methods: Here, we used a whole-exome sequencing (WES) appro...

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Bibliographic Details
Main Authors: Xianxian Liu, Jiusheng Zheng, Siming Xin, Yang Zeng, Xiaoying Wu, Xiaoming Zeng, Hua Lai, Yang Zou
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Genetics
Subjects:
ICP
WES
OTAPs
ABCs
receptors
novel mutations
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.941027/full

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