Association Between Alcohol Consumption and Ectopic Fat in the Multi‐Ethnic Study of Atherosclerosis
Background The relationship between alcohol consumption and ectopic fat distribution, both known factors for cardiovascular disease, remains understudied. Therefore, we aimed to examine the association between alcohol consumption and ectopic adiposity in adults at risk for cardiovascular disease. Me...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-09-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.123.030470 |
| _version_ | 1797632526089453568 |
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| author | Richard Kazibwe Parag A. Chevli Joni K. Evans Matthew Allison Erin D. Michos Alexis C. Wood Jingzhong Ding Michael D. Shapiro Morgana Mongraw‐Chaffin |
| author_facet | Richard Kazibwe Parag A. Chevli Joni K. Evans Matthew Allison Erin D. Michos Alexis C. Wood Jingzhong Ding Michael D. Shapiro Morgana Mongraw‐Chaffin |
| author_sort | Richard Kazibwe |
| collection | DOAJ |
| description | Background The relationship between alcohol consumption and ectopic fat distribution, both known factors for cardiovascular disease, remains understudied. Therefore, we aimed to examine the association between alcohol consumption and ectopic adiposity in adults at risk for cardiovascular disease. Methods and Results In this cross‐sectional analysis, we categorized alcohol intake among participants in MESA (Multi‐Ethnic Study of Atherosclerosis) as follows (drinks/day): <1 (light drinking), 1 to 2 (moderate drinking), >2 (heavy drinking), former drinking, and lifetime abstention. Binge drinking was defined as consuming ≥5 drinks on 1 occasion in the past month. Visceral, subcutaneous, and intermuscular fat area, pericardial fat volume, and hepatic fat attenuation were measured using noncontrast computed tomography. Using multivariable linear regression, we examined the associations between categories of alcohol consumption and natural log‐transformed fat in ectopic depots. We included 6756 MESA participants (62.1±10.2 years; 47.2% women), of whom 6734 and 1934 had chest computed tomography (pericardial and hepatic fat) and abdominal computed tomography (subcutaneous, intermuscular, and visceral fat), respectively. In adjusted analysis, heavy drinking, relative to lifetime abstention, was associated with a higher (relative percent difference) pericardial 15.1 [95% CI, 7.1–27.7], hepatic 3.4 [95% CI, 0.1–6.8], visceral 2.5 [95% CI, −10.4 to 17.2], and intermuscular 5.2 [95% CI, −6.6 to 18.4] fat but lower subcutaneous fat −3.5 [95% CI, −15.5 to 10.2]). The associations between alcohol consumption and ectopic adiposity exhibited a J‐shaped pattern. Binge drinking, relative to light‐to‐moderate drinking, was also associated with higher ectopic fat. Conclusions Alcohol consumption had a J‐shaped association with ectopic adiposity. Both heavy alcohol intake and binge alcohol drinking were associated with higher ectopic fat. |
| first_indexed | 2024-03-11T11:38:15Z |
| format | Article |
| id | doaj.art-16c2cb4e962e4ab48dba411b28f89d39 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-03-11T11:38:15Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-16c2cb4e962e4ab48dba411b28f89d392023-11-10T10:23:41ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802023-09-01121810.1161/JAHA.123.030470Association Between Alcohol Consumption and Ectopic Fat in the Multi‐Ethnic Study of AtherosclerosisRichard Kazibwe0Parag A. Chevli1Joni K. Evans2Matthew Allison3Erin D. Michos4Alexis C. Wood5Jingzhong Ding6Michael D. Shapiro7Morgana Mongraw‐Chaffin8Department of Internal Medicine, Section on Hospital Medicine Wake Forest University School of Medicine Winston Salem NC USADepartment of Internal Medicine, Section on Hospital Medicine Wake Forest University School of Medicine Winston Salem NC USADepartment of Biostatistics and Data Science Wake Forest University School of Medicine Winston‐Salem NC USADepartment of Family Medicine University of California San Diego La Jolla CA USADivision of Cardiology, Department of Medicine Johns Hopkins School of Medicine Baltimore MD USAUSDA/ARS Children’s Nutrition Research Center Baylor College of Medicine Houston TX USADepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine Wake Forest School of Medicine Winston‐Salem NC USACenter for the Prevention of Cardiovascular Disease Section on Cardiovascular Medicine Wake Forest University School of Medicine Winston‐Salem NC USADepartment of Epidemiology & Prevention Wake Forest School of Medicine Winston‐Salem NC USABackground The relationship between alcohol consumption and ectopic fat distribution, both known factors for cardiovascular disease, remains understudied. Therefore, we aimed to examine the association between alcohol consumption and ectopic adiposity in adults at risk for cardiovascular disease. Methods and Results In this cross‐sectional analysis, we categorized alcohol intake among participants in MESA (Multi‐Ethnic Study of Atherosclerosis) as follows (drinks/day): <1 (light drinking), 1 to 2 (moderate drinking), >2 (heavy drinking), former drinking, and lifetime abstention. Binge drinking was defined as consuming ≥5 drinks on 1 occasion in the past month. Visceral, subcutaneous, and intermuscular fat area, pericardial fat volume, and hepatic fat attenuation were measured using noncontrast computed tomography. Using multivariable linear regression, we examined the associations between categories of alcohol consumption and natural log‐transformed fat in ectopic depots. We included 6756 MESA participants (62.1±10.2 years; 47.2% women), of whom 6734 and 1934 had chest computed tomography (pericardial and hepatic fat) and abdominal computed tomography (subcutaneous, intermuscular, and visceral fat), respectively. In adjusted analysis, heavy drinking, relative to lifetime abstention, was associated with a higher (relative percent difference) pericardial 15.1 [95% CI, 7.1–27.7], hepatic 3.4 [95% CI, 0.1–6.8], visceral 2.5 [95% CI, −10.4 to 17.2], and intermuscular 5.2 [95% CI, −6.6 to 18.4] fat but lower subcutaneous fat −3.5 [95% CI, −15.5 to 10.2]). The associations between alcohol consumption and ectopic adiposity exhibited a J‐shaped pattern. Binge drinking, relative to light‐to‐moderate drinking, was also associated with higher ectopic fat. Conclusions Alcohol consumption had a J‐shaped association with ectopic adiposity. Both heavy alcohol intake and binge alcohol drinking were associated with higher ectopic fat.https://www.ahajournals.org/doi/10.1161/JAHA.123.030470alcohol consumptioncardiovascular diseaseectopic fat |
| spellingShingle | Richard Kazibwe Parag A. Chevli Joni K. Evans Matthew Allison Erin D. Michos Alexis C. Wood Jingzhong Ding Michael D. Shapiro Morgana Mongraw‐Chaffin Association Between Alcohol Consumption and Ectopic Fat in the Multi‐Ethnic Study of Atherosclerosis Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease alcohol consumption cardiovascular disease ectopic fat |
| title | Association Between Alcohol Consumption and Ectopic Fat in the Multi‐Ethnic Study of Atherosclerosis |
| title_full | Association Between Alcohol Consumption and Ectopic Fat in the Multi‐Ethnic Study of Atherosclerosis |
| title_fullStr | Association Between Alcohol Consumption and Ectopic Fat in the Multi‐Ethnic Study of Atherosclerosis |
| title_full_unstemmed | Association Between Alcohol Consumption and Ectopic Fat in the Multi‐Ethnic Study of Atherosclerosis |
| title_short | Association Between Alcohol Consumption and Ectopic Fat in the Multi‐Ethnic Study of Atherosclerosis |
| title_sort | association between alcohol consumption and ectopic fat in the multi ethnic study of atherosclerosis |
| topic | alcohol consumption cardiovascular disease ectopic fat |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.123.030470 |
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