Anti-inflammatory actions of Pentosan polysulfate sodium in a mouse model of influenza virus A/PR8/34-induced pulmonary inflammation

Anti-inflammatory actions of Pentosan polysulfate sodium in a mouse model of influenza virus A/PR8/34-induced pulmonary inflammation

IntroductionThere is an unmet medical need for effective anti-inflammatory agents for the treatment of acute and post-acute lung inflammation caused by respiratory viruses. The semi-synthetic polysaccharide, Pentosan polysulfate sodium (PPS), an inhibitor of NF-kB activation, was investigated for it...

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Bibliographic Details
Main Authors: Ravi Krishnan, Catherine J. M. Stapledon, Helen Mostafavi, Joseph R. Freitas, Xiang Liu, Suresh Mahalingam, Ali Zaid
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
influenza A virus
Pentosan polysulfate sodium
acute inflammation
cytokines and chemokines
lung consolidation
lung fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1030879/full

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