Tauroursodeoxycholic Acid Reduces Neuroinflammation but Does Not Support Long Term Functional Recovery of Rats with Spinal Cord Injury

Tauroursodeoxycholic Acid Reduces Neuroinflammation but Does Not Support Long Term Functional Recovery of Rats with Spinal Cord Injury

The bile acid tauroursodeoxycholic acid (TUDCA) reduces cell death under oxidative stress and inflammation. Implants of bone marrow-derived stromal cells (bmSC) are currently under investigation in clinical trials of spinal cord injury (SCI). Since cell death of injected bmSC limits the efficacy of...

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Bibliographic Details
Main Authors: Siyu Wu, Concepción García-Rama, Lorenzo Romero-Ramírez, Johannes P. J. M. de Munter, Erik Ch. Wolters, Boris W. Kramer, Jörg Mey
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Biomedicines
Subjects:
bile acid
spinal cord injury
bone marrow-derived stromal cells
rat
neuroinflammation
Online Access:https://www.mdpi.com/2227-9059/10/7/1501

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