Young coconut juice can accelerate the healing process of cutaneous wounds
<p>Abstract</p> <p>Background</p> <p>Estrogen has been reported to accelerate cutaneous wound healing. This research studies the effect of young coconut juice (YCJ), presumably containing estrogen-like substances, on cutaneous wound healing in ovairectomized rats.</p...
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| Format: | Article |
| Language: | English |
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BMC
2012-12-01
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| Series: | BMC Complementary and Alternative Medicine |
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| Online Access: | http://www.biomedcentral.com/1472-6882/12/252 |
| _version_ | 1811265902841167872 |
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| author | Radenahmad Nisaudah Saleh Farid Sayoh Ibrahim Sawangjaroen Kitja Subhadhirasakul Patchara Boonyoung Piyakorn Rundorn Wilart Mitranun Winyou |
| author_facet | Radenahmad Nisaudah Saleh Farid Sayoh Ibrahim Sawangjaroen Kitja Subhadhirasakul Patchara Boonyoung Piyakorn Rundorn Wilart Mitranun Winyou |
| author_sort | Radenahmad Nisaudah |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Estrogen has been reported to accelerate cutaneous wound healing. This research studies the effect of young coconut juice (YCJ), presumably containing estrogen-like substances, on cutaneous wound healing in ovairectomized rats.</p> <p>Methods</p> <p>Four groups of female rats (6 in each group) were included in this study. These included sham-operated, ovariectomized (ovx), ovx receiving estradiol benzoate (EB) injections intraperitoneally, and ovx receiving YCJ orally. Two equidistant 1-cm full-thickness skin incisional wounds were made two weeks after ovariectomy. The rats were sacrificed at the end of the third and the fourth week of the study, and their serum estradiol (E2) level was measured by chemiluminescent immunoassay. The skin was excised and examined in histological sections stained with H&E, and immunostained using anti-estrogen receptor (ER-α an ER-β) antibodies.</p> <p>Results</p> <p>Wound healing was accelerated in ovx rats receiving YCJ, as compared to controls. This was associated with significantly higher density of immunostaining for ER-α an ER-β in keratinocytes, fibroblasts, white blood cells, fat cells, sebaceous gland, skeletal muscles, and hair shafts and follicles. This was also associated with thicker epidermis and dermis, but with thinner hypodermis. In addition, the number and size of immunoreactive hair follicles for both ER-α and ER-β were the highest in the ovx+YCJ group, as compared to the ovx+EB group.</p> <p>Conclusions</p> <p>This study demonstrates that YCJ has estrogen-like characteristics, which in turn seem to have beneficial effects on cutaneous wound healing.</p> |
| first_indexed | 2024-04-12T20:32:20Z |
| format | Article |
| id | doaj.art-16c617ad9d6c411f975fdf68c9542ce5 |
| institution | Directory Open Access Journal |
| issn | 1472-6882 |
| language | English |
| last_indexed | 2024-04-12T20:32:20Z |
| publishDate | 2012-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Complementary and Alternative Medicine |
| spelling | doaj.art-16c617ad9d6c411f975fdf68c9542ce52022-12-22T03:17:42ZengBMCBMC Complementary and Alternative Medicine1472-68822012-12-0112125210.1186/1472-6882-12-252Young coconut juice can accelerate the healing process of cutaneous woundsRadenahmad NisaudahSaleh FaridSayoh IbrahimSawangjaroen KitjaSubhadhirasakul PatcharaBoonyoung PiyakornRundorn WilartMitranun Winyou<p>Abstract</p> <p>Background</p> <p>Estrogen has been reported to accelerate cutaneous wound healing. This research studies the effect of young coconut juice (YCJ), presumably containing estrogen-like substances, on cutaneous wound healing in ovairectomized rats.</p> <p>Methods</p> <p>Four groups of female rats (6 in each group) were included in this study. These included sham-operated, ovariectomized (ovx), ovx receiving estradiol benzoate (EB) injections intraperitoneally, and ovx receiving YCJ orally. Two equidistant 1-cm full-thickness skin incisional wounds were made two weeks after ovariectomy. The rats were sacrificed at the end of the third and the fourth week of the study, and their serum estradiol (E2) level was measured by chemiluminescent immunoassay. The skin was excised and examined in histological sections stained with H&E, and immunostained using anti-estrogen receptor (ER-α an ER-β) antibodies.</p> <p>Results</p> <p>Wound healing was accelerated in ovx rats receiving YCJ, as compared to controls. This was associated with significantly higher density of immunostaining for ER-α an ER-β in keratinocytes, fibroblasts, white blood cells, fat cells, sebaceous gland, skeletal muscles, and hair shafts and follicles. This was also associated with thicker epidermis and dermis, but with thinner hypodermis. In addition, the number and size of immunoreactive hair follicles for both ER-α and ER-β were the highest in the ovx+YCJ group, as compared to the ovx+EB group.</p> <p>Conclusions</p> <p>This study demonstrates that YCJ has estrogen-like characteristics, which in turn seem to have beneficial effects on cutaneous wound healing.</p>http://www.biomedcentral.com/1472-6882/12/252Young coconut juiceWound healingEstrogenER-αER-βOvariectomy |
| spellingShingle | Radenahmad Nisaudah Saleh Farid Sayoh Ibrahim Sawangjaroen Kitja Subhadhirasakul Patchara Boonyoung Piyakorn Rundorn Wilart Mitranun Winyou Young coconut juice can accelerate the healing process of cutaneous wounds BMC Complementary and Alternative Medicine Young coconut juice Wound healing Estrogen ER-α ER-β Ovariectomy |
| title | Young coconut juice can accelerate the healing process of cutaneous wounds |
| title_full | Young coconut juice can accelerate the healing process of cutaneous wounds |
| title_fullStr | Young coconut juice can accelerate the healing process of cutaneous wounds |
| title_full_unstemmed | Young coconut juice can accelerate the healing process of cutaneous wounds |
| title_short | Young coconut juice can accelerate the healing process of cutaneous wounds |
| title_sort | young coconut juice can accelerate the healing process of cutaneous wounds |
| topic | Young coconut juice Wound healing Estrogen ER-α ER-β Ovariectomy |
| url | http://www.biomedcentral.com/1472-6882/12/252 |
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