Regulation of Phagocyte Migration by Signal Regulatory Protein-Alpha Signaling.
Signaling through the inhibitory receptor signal regulatory protein-alpha (SIRPα) controls effector functions in phagocytes. However, there are also indications that interactions between SIRPα and its ligand CD47 are involved in phagocyte transendothelial migration. We have investigated the involvem...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4461249?pdf=render |
| _version_ | 1819168831634931712 |
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| author | Julian Alvarez-Zarate Hanke L Matlung Takashi Matozaki Taco W Kuijpers Isabelle Maridonneau-Parini Timo K van den Berg |
| author_facet | Julian Alvarez-Zarate Hanke L Matlung Takashi Matozaki Taco W Kuijpers Isabelle Maridonneau-Parini Timo K van den Berg |
| author_sort | Julian Alvarez-Zarate |
| collection | DOAJ |
| description | Signaling through the inhibitory receptor signal regulatory protein-alpha (SIRPα) controls effector functions in phagocytes. However, there are also indications that interactions between SIRPα and its ligand CD47 are involved in phagocyte transendothelial migration. We have investigated the involvement of SIRPα signaling in phagocyte migration in vitro and in vivo using mice that lack the SIRPα cytoplasmic tail. During thioglycolate-induced peritonitis in SIRPα mutant mice, both neutrophil and macrophage influx were found to occur, but to be significantly delayed. SIRPα signaling appeared to be essential for an optimal transendothelial migration and chemotaxis, and for the amoeboid type of phagocyte migration in 3-dimensional environments. These findings demonstrate, for the first time, that SIRPα signaling can directly control phagocyte migration, and this may contribute to the impaired inflammatory phenotype that has been observed in the absence of SIRPα signaling. |
| first_indexed | 2024-12-22T19:09:51Z |
| format | Article |
| id | doaj.art-16c7bebaacba47c989e5e1465314a8fd |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T19:09:51Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-16c7bebaacba47c989e5e1465314a8fd2022-12-21T18:15:42ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01106e012717810.1371/journal.pone.0127178Regulation of Phagocyte Migration by Signal Regulatory Protein-Alpha Signaling.Julian Alvarez-ZarateHanke L MatlungTakashi MatozakiTaco W KuijpersIsabelle Maridonneau-PariniTimo K van den BergSignaling through the inhibitory receptor signal regulatory protein-alpha (SIRPα) controls effector functions in phagocytes. However, there are also indications that interactions between SIRPα and its ligand CD47 are involved in phagocyte transendothelial migration. We have investigated the involvement of SIRPα signaling in phagocyte migration in vitro and in vivo using mice that lack the SIRPα cytoplasmic tail. During thioglycolate-induced peritonitis in SIRPα mutant mice, both neutrophil and macrophage influx were found to occur, but to be significantly delayed. SIRPα signaling appeared to be essential for an optimal transendothelial migration and chemotaxis, and for the amoeboid type of phagocyte migration in 3-dimensional environments. These findings demonstrate, for the first time, that SIRPα signaling can directly control phagocyte migration, and this may contribute to the impaired inflammatory phenotype that has been observed in the absence of SIRPα signaling.http://europepmc.org/articles/PMC4461249?pdf=render |
| spellingShingle | Julian Alvarez-Zarate Hanke L Matlung Takashi Matozaki Taco W Kuijpers Isabelle Maridonneau-Parini Timo K van den Berg Regulation of Phagocyte Migration by Signal Regulatory Protein-Alpha Signaling. PLoS ONE |
| title | Regulation of Phagocyte Migration by Signal Regulatory Protein-Alpha Signaling. |
| title_full | Regulation of Phagocyte Migration by Signal Regulatory Protein-Alpha Signaling. |
| title_fullStr | Regulation of Phagocyte Migration by Signal Regulatory Protein-Alpha Signaling. |
| title_full_unstemmed | Regulation of Phagocyte Migration by Signal Regulatory Protein-Alpha Signaling. |
| title_short | Regulation of Phagocyte Migration by Signal Regulatory Protein-Alpha Signaling. |
| title_sort | regulation of phagocyte migration by signal regulatory protein alpha signaling |
| url | http://europepmc.org/articles/PMC4461249?pdf=render |
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