Cardiovascular effects of intensive lifestyle intervention in adults with overweight/obesity and type 2 diabetes according to body weight time in range
Summary: Background: We aimed to assess whether the cardiovascular effects of intensive lifestyle intervention (ILI) vary for those who can maintain the lower body weight after weight loss through ILI. Methods: In the secondary analysis of the Look AHEAD trial, we identified the status of weight lo...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | EClinicalMedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S258953702200181X |
| _version_ | 1818214166178037760 |
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| author | Menghui Liu Rihua Huang Lin Xu Shaozhao Zhang Xiangbin Zhong Xiaohong Chen Yifen Lin Zhenyu Xiong Lichun Wang Xinxue Liao Xiaodong Zhuang |
| author_facet | Menghui Liu Rihua Huang Lin Xu Shaozhao Zhang Xiangbin Zhong Xiaohong Chen Yifen Lin Zhenyu Xiong Lichun Wang Xinxue Liao Xiaodong Zhuang |
| author_sort | Menghui Liu |
| collection | DOAJ |
| description | Summary: Background: We aimed to assess whether the cardiovascular effects of intensive lifestyle intervention (ILI) vary for those who can maintain the lower body weight after weight loss through ILI. Methods: In the secondary analysis of the Look AHEAD trial, we identified the status of weight loss for the participants in the ILI arm based on body weight time in range (TIR). These participants were allocated to three groups according to body weight TIR: 0% (n = 727), >0% to 50% (n = 656), and >50% to 100% (n = 811). For each group, cardiovascular outcomes were compared with matched participants receiving diabetes support & education (DSE) using 1:1 propensity score matching and Cox regression. Findings: During a median of 9·5 years of follow-up, participants with TIR of >50% to 100% can effectively maintain their body weight after weight loss through ILI; participants with TIR of 0% or >0% to 50% do not achieve or maintain weight loss. Compared with the corresponding matched participants in the DSE arm, participants with TIR of >50% to 100% in the ILI arm had a 45% lower risk of the primary outcome (HR 0·55, 95% CI 0·40–0·76), and no significant effects were found on the risk of the primary outcome in participants with TIR of 0% (HR 1·12, 95% CI 0·86–1·46) or >0% to 50% (HR 1·14, 95% CI 0·85–1·52). Interpretation: In adults with overweight/obesity and type 2 diabetes, ILI might help in lowering the risk of cardiovascular events when the lower body weight is maintained after weight loss. Funding: None. |
| first_indexed | 2024-12-12T06:15:51Z |
| format | Article |
| id | doaj.art-16c9615c77894bd386396c2b58a59103 |
| institution | Directory Open Access Journal |
| issn | 2589-5370 |
| language | English |
| last_indexed | 2024-12-12T06:15:51Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EClinicalMedicine |
| spelling | doaj.art-16c9615c77894bd386396c2b58a591032022-12-22T00:35:01ZengElsevierEClinicalMedicine2589-53702022-07-0149101451Cardiovascular effects of intensive lifestyle intervention in adults with overweight/obesity and type 2 diabetes according to body weight time in rangeMenghui Liu0Rihua Huang1Lin Xu2Shaozhao Zhang3Xiangbin Zhong4Xiaohong Chen5Yifen Lin6Zhenyu Xiong7Lichun Wang8Xinxue Liao9Xiaodong Zhuang10Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan 2nd Rd., Guangzhou 510080, China; NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, ChinaDepartment of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan 2nd Rd., Guangzhou 510080, China; NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, ChinaSchool of Public Health, Sun Yat-sen University, Guangzhou, ChinaDepartment of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan 2nd Rd., Guangzhou 510080, China; NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, ChinaDepartment of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan 2nd Rd., Guangzhou 510080, China; NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, ChinaThe Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, ChinaDepartment of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan 2nd Rd., Guangzhou 510080, China; NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, ChinaDepartment of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan 2nd Rd., Guangzhou 510080, China; NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, ChinaDepartment of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan 2nd Rd., Guangzhou 510080, China; NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, ChinaDepartment of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan 2nd Rd., Guangzhou 510080, China; NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China; Corresponding author at: Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan 2nd Rd., Guangzhou 510080, China.Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan 2nd Rd., Guangzhou 510080, China; NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China; Corresponding author at: Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan 2nd Rd., Guangzhou 510080, China.Summary: Background: We aimed to assess whether the cardiovascular effects of intensive lifestyle intervention (ILI) vary for those who can maintain the lower body weight after weight loss through ILI. Methods: In the secondary analysis of the Look AHEAD trial, we identified the status of weight loss for the participants in the ILI arm based on body weight time in range (TIR). These participants were allocated to three groups according to body weight TIR: 0% (n = 727), >0% to 50% (n = 656), and >50% to 100% (n = 811). For each group, cardiovascular outcomes were compared with matched participants receiving diabetes support & education (DSE) using 1:1 propensity score matching and Cox regression. Findings: During a median of 9·5 years of follow-up, participants with TIR of >50% to 100% can effectively maintain their body weight after weight loss through ILI; participants with TIR of 0% or >0% to 50% do not achieve or maintain weight loss. Compared with the corresponding matched participants in the DSE arm, participants with TIR of >50% to 100% in the ILI arm had a 45% lower risk of the primary outcome (HR 0·55, 95% CI 0·40–0·76), and no significant effects were found on the risk of the primary outcome in participants with TIR of 0% (HR 1·12, 95% CI 0·86–1·46) or >0% to 50% (HR 1·14, 95% CI 0·85–1·52). Interpretation: In adults with overweight/obesity and type 2 diabetes, ILI might help in lowering the risk of cardiovascular events when the lower body weight is maintained after weight loss. Funding: None.http://www.sciencedirect.com/science/article/pii/S258953702200181XBody weightIntensive lifestyle interventionObesityTime in rangeType 2 diabetes |
| spellingShingle | Menghui Liu Rihua Huang Lin Xu Shaozhao Zhang Xiangbin Zhong Xiaohong Chen Yifen Lin Zhenyu Xiong Lichun Wang Xinxue Liao Xiaodong Zhuang Cardiovascular effects of intensive lifestyle intervention in adults with overweight/obesity and type 2 diabetes according to body weight time in range EClinicalMedicine Body weight Intensive lifestyle intervention Obesity Time in range Type 2 diabetes |
| title | Cardiovascular effects of intensive lifestyle intervention in adults with overweight/obesity and type 2 diabetes according to body weight time in range |
| title_full | Cardiovascular effects of intensive lifestyle intervention in adults with overweight/obesity and type 2 diabetes according to body weight time in range |
| title_fullStr | Cardiovascular effects of intensive lifestyle intervention in adults with overweight/obesity and type 2 diabetes according to body weight time in range |
| title_full_unstemmed | Cardiovascular effects of intensive lifestyle intervention in adults with overweight/obesity and type 2 diabetes according to body weight time in range |
| title_short | Cardiovascular effects of intensive lifestyle intervention in adults with overweight/obesity and type 2 diabetes according to body weight time in range |
| title_sort | cardiovascular effects of intensive lifestyle intervention in adults with overweight obesity and type 2 diabetes according to body weight time in range |
| topic | Body weight Intensive lifestyle intervention Obesity Time in range Type 2 diabetes |
| url | http://www.sciencedirect.com/science/article/pii/S258953702200181X |
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