Autophagy in Atherosclerotic Plaque Cells: Targeting NLRP3 Inflammasome for Self-Rescue
Atherosclerosis (AS) is a lipid-driven disorder of the artery intima characterized by the equilibrium between inflammatory and regressive processes. A protein complex called NLRP3 inflammasome is involved in the release of mature interleukin-1β (IL-1β), which is connected to the initiation and progr...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/1/15 |
| _version_ | 1797445517235453952 |
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| author | Xuelian Li Xianjie Zhu Yumiao Wei |
| author_facet | Xuelian Li Xianjie Zhu Yumiao Wei |
| author_sort | Xuelian Li |
| collection | DOAJ |
| description | Atherosclerosis (AS) is a lipid-driven disorder of the artery intima characterized by the equilibrium between inflammatory and regressive processes. A protein complex called NLRP3 inflammasome is involved in the release of mature interleukin-1β (IL-1β), which is connected to the initiation and progression of atherosclerosis. Autophagy, which includes macroautophagy, chaperone-mediated autophagy (CMA), and microautophagy, is generally recognized as the process by which cells transfer their constituents to lysosomes for digestion. Recent studies have suggested a connection between vascular inflammation and autophagy. This review summarizes the most recent studies and the underlying mechanisms associated with different autophagic pathways and NLRP3 inflammasomes in vascular inflammation, aiming to provide additional evidence for atherosclerosis research. |
| first_indexed | 2024-03-09T13:27:54Z |
| format | Article |
| id | doaj.art-16c979dbec20439591f9521e61d8a8bd |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T13:27:54Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-16c979dbec20439591f9521e61d8a8bd2023-11-30T21:21:33ZengMDPI AGBiomolecules2218-273X2022-12-011311510.3390/biom13010015Autophagy in Atherosclerotic Plaque Cells: Targeting NLRP3 Inflammasome for Self-RescueXuelian Li0Xianjie Zhu1Yumiao Wei2Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Orthopaedic Surgery, Qingdao Municipal Hospital, Qingdao 266011, ChinaDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaAtherosclerosis (AS) is a lipid-driven disorder of the artery intima characterized by the equilibrium between inflammatory and regressive processes. A protein complex called NLRP3 inflammasome is involved in the release of mature interleukin-1β (IL-1β), which is connected to the initiation and progression of atherosclerosis. Autophagy, which includes macroautophagy, chaperone-mediated autophagy (CMA), and microautophagy, is generally recognized as the process by which cells transfer their constituents to lysosomes for digestion. Recent studies have suggested a connection between vascular inflammation and autophagy. This review summarizes the most recent studies and the underlying mechanisms associated with different autophagic pathways and NLRP3 inflammasomes in vascular inflammation, aiming to provide additional evidence for atherosclerosis research.https://www.mdpi.com/2218-273X/13/1/15autophagymitophagyNLRP3 inflammasomeatherosclerosis |
| spellingShingle | Xuelian Li Xianjie Zhu Yumiao Wei Autophagy in Atherosclerotic Plaque Cells: Targeting NLRP3 Inflammasome for Self-Rescue Biomolecules autophagy mitophagy NLRP3 inflammasome atherosclerosis |
| title | Autophagy in Atherosclerotic Plaque Cells: Targeting NLRP3 Inflammasome for Self-Rescue |
| title_full | Autophagy in Atherosclerotic Plaque Cells: Targeting NLRP3 Inflammasome for Self-Rescue |
| title_fullStr | Autophagy in Atherosclerotic Plaque Cells: Targeting NLRP3 Inflammasome for Self-Rescue |
| title_full_unstemmed | Autophagy in Atherosclerotic Plaque Cells: Targeting NLRP3 Inflammasome for Self-Rescue |
| title_short | Autophagy in Atherosclerotic Plaque Cells: Targeting NLRP3 Inflammasome for Self-Rescue |
| title_sort | autophagy in atherosclerotic plaque cells targeting nlrp3 inflammasome for self rescue |
| topic | autophagy mitophagy NLRP3 inflammasome atherosclerosis |
| url | https://www.mdpi.com/2218-273X/13/1/15 |
| work_keys_str_mv | AT xuelianli autophagyinatheroscleroticplaquecellstargetingnlrp3inflammasomeforselfrescue AT xianjiezhu autophagyinatheroscleroticplaquecellstargetingnlrp3inflammasomeforselfrescue AT yumiaowei autophagyinatheroscleroticplaquecellstargetingnlrp3inflammasomeforselfrescue |