Prescribing Pattern of Proton Pump Inhibitors (PPI) and Histamine Blockers in a Tertiary Care Hospital
Introduction: Gastric problems are the most common diseases seen in many countries for which majority of the population prefer Proton Pump Inhibitors (PPI) and Histamine (H2) Blockers. They are prescribed most commonly for Gastroesophageal Reflux Disease (GERD), Dyspepsia, Peptic Ulcer Disease,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2020-10-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/14136/45123_CE[Ra1]_F(SL)_PF1(F_KM)_PN(SL).pdf |
| Summary: | Introduction: Gastric problems are the most common diseases
seen in many countries for which majority of the population
prefer Proton Pump Inhibitors (PPI) and Histamine (H2) Blockers.
They are prescribed most commonly for Gastroesophageal
Reflux Disease (GERD), Dyspepsia, Peptic Ulcer Disease, alongwith medications like Non-Steroidal Antiinflammatory Drugs
(NSAIDs) and other drugs. Concerns have been raised about the
increasing costs associated with prescription of these drugs as
they are often prescribed for minor symptoms and without clear
indications. Prescribing pattern should be evaluated periodically
to promote rational use of medicines.
Aim: To assess the prescribing pattern of PPIs and H2 Blockers in
Surgery and Medicine Department of a Tertiary Care Hospital.
Materials and Methods: An observational study was conducted
in a Tertiary Care Hospital, Karamsad over a period of one year
from November, 2018 to October, 2019, among patients visiting
to Out Patient Department (OPD) and In Patient Department (IPD)
of Medicine and Surgery Department that were prescribed PPI
and H2 Blockers. Total 1100 prescriptions and 1265 PPI, H2
Blockers were analysed. The data were analysed for sociodemographic variables along with details of PPI and H2 Blockers.
co-prescribing drugs, Fixed Dose Combinations (FDCs) and
drug interactions of each prescription was analysed.
Results: In the study, PPI and H2 Blockers were prescribed more
in males (54.36%). The predominant age group was 18-40 years
(42%). Among studied drugs, most commonly prescribed single
drug was Pantoprazole and FDC was Ranitidine + Domperidone.
The drugs were most commonly prescribed through oral route
(90.9%). They were most commonly prescribed along with an
NSAID for gastroprotection (28.9%). Pharmacokinetic drug
interactions were observed more in the study.
Conclusion: This study showed that physicians prescribe PPI
and H2 Blockers as a co-medication for gastroprotection. There
is a need to increase documentation for prescribing PPI and H2
Blockers. |
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| ISSN: | 2249-782X 0973-709X |