PGAM1 Promotes Glycolytic Metabolism and Paclitaxel Resistance via Pyruvic Acid Production in Ovarian Cancer Cells

PGAM1 Promotes Glycolytic Metabolism and Paclitaxel Resistance via Pyruvic Acid Production in Ovarian Cancer Cells

Background: Enhanced glycolysis occurs in most human cancer cells and is related to chemoresistance. However, detailed mechanisms remain vague. Methods: Using proteinomics analysis, we found that the glycolytic enzyme Phosphoglycerate mutase 1 (PGAM1) was highly expressed in the paclitaxel-resistant...

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Bibliographic Details
Main Authors: Yan Feng, Xu Zhang, Songfa Zhang, Shanshan Xu, Xiaojing Chen, Caiyun Zhou, Yongmei Xi, Xing Xie, Weiguo Lu
Format: Article
Language:English
Published: IMR Press 2022-09-01
Series:Frontiers in Bioscience-Landmark
Subjects:
phosphoglycerate mutase 1
paclitaxel resistance
glycolysis
pyruvate
ovarian cancer cell
Online Access:https://www.imrpress.com/journal/FBL/27/9/10.31083/j.fbl2709262

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