p53, SKP2 and DKK3 as MYCN target genes and their potential therapeutic significance
Neuroblastoma is the most common extracranial solid tumour of childhood. Despite significant advances, it currently still remains one of the most difficult childhood cancers to cure, with less than 40% of patients with high-risk disease being long-term survivors. MYCN is a proto-oncogene implicated...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-11-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00173/full |
| _version_ | 1811194001536057344 |
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| author | Lindi eChen Deborah Anne Tweddle |
| author_facet | Lindi eChen Deborah Anne Tweddle |
| author_sort | Lindi eChen |
| collection | DOAJ |
| description | Neuroblastoma is the most common extracranial solid tumour of childhood. Despite significant advances, it currently still remains one of the most difficult childhood cancers to cure, with less than 40% of patients with high-risk disease being long-term survivors. MYCN is a proto-oncogene implicated to be directly involved in neuroblastoma development. Amplification of MYCN is associated with rapid tumour progression and poor prognosis. Novel therapeutic strategies which can improve the survival rates whilst reducing the toxicity in these patients are therefore required. Here we discuss genes regulated by MYCN in neuroblastoma, with particular reference to p53, SKP2 and DKK3 and strategies that may be employed to target them. |
| first_indexed | 2024-04-12T00:19:49Z |
| format | Article |
| id | doaj.art-16caeadd464546b0b44c8d10c1745394 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T00:19:49Z |
| publishDate | 2012-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-16caeadd464546b0b44c8d10c17453942022-12-22T03:55:45ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2012-11-01210.3389/fonc.2012.0017335360p53, SKP2 and DKK3 as MYCN target genes and their potential therapeutic significanceLindi eChen0Deborah Anne Tweddle1Newcastle UniversityNewcastle UniversityNeuroblastoma is the most common extracranial solid tumour of childhood. Despite significant advances, it currently still remains one of the most difficult childhood cancers to cure, with less than 40% of patients with high-risk disease being long-term survivors. MYCN is a proto-oncogene implicated to be directly involved in neuroblastoma development. Amplification of MYCN is associated with rapid tumour progression and poor prognosis. Novel therapeutic strategies which can improve the survival rates whilst reducing the toxicity in these patients are therefore required. Here we discuss genes regulated by MYCN in neuroblastoma, with particular reference to p53, SKP2 and DKK3 and strategies that may be employed to target them.http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00173/fullNeuroblastomap53Skp2MYCNDKK3MDM2-p53 antagonists |
| spellingShingle | Lindi eChen Deborah Anne Tweddle p53, SKP2 and DKK3 as MYCN target genes and their potential therapeutic significance Frontiers in Oncology Neuroblastoma p53 Skp2 MYCN DKK3 MDM2-p53 antagonists |
| title | p53, SKP2 and DKK3 as MYCN target genes and their potential therapeutic significance |
| title_full | p53, SKP2 and DKK3 as MYCN target genes and their potential therapeutic significance |
| title_fullStr | p53, SKP2 and DKK3 as MYCN target genes and their potential therapeutic significance |
| title_full_unstemmed | p53, SKP2 and DKK3 as MYCN target genes and their potential therapeutic significance |
| title_short | p53, SKP2 and DKK3 as MYCN target genes and their potential therapeutic significance |
| title_sort | p53 skp2 and dkk3 as mycn target genes and their potential therapeutic significance |
| topic | Neuroblastoma p53 Skp2 MYCN DKK3 MDM2-p53 antagonists |
| url | http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00173/full |
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