Safety of nonsteroidal anti-inflammatory drugs in patients with cardiovascular risk
The review presents current information on the role of NSAIDs in the development of cardiovascular disasters. The development of non-desirable cardiovascular effects and an increase in cardiovascular risk with the administration of NSAIDs, most experts assess in terms of the antagonistic effect on t...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
"Consilium Medicum" Publishing house
2019-01-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/32955/pdf |
| _version_ | 1818134655840288768 |
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| author | A V Naumov O N Tkacheva N O Khovasova |
| author_facet | A V Naumov O N Tkacheva N O Khovasova |
| author_sort | A V Naumov |
| collection | DOAJ |
| description | The review presents current information on the role of NSAIDs in the development of cardiovascular disasters. The development of non-desirable cardiovascular effects and an increase in cardiovascular risk with the administration of NSAIDs, most experts assess in terms of the antagonistic effect on the platelet-vascular homeostasis of metabolites of COX-thromboxane A2 and prostaglandin I2 (prostacyclin). All the presented reviews confirming an increase in the risk of MI complications in the administration of NSAIDs, indicate the class-specificity of this undesirable effect, not homogeneous for different representatives of the group. Important clinical aspects of prescribing NSAIDs for patients with low and moderate cardiovascular risk are the clinical features of the patient and the individual set of risk factors for CVD. Such pharmacokinetic characteristics of NSAIDs as a short half-life, a high degree of binding to blood plasma albumins are indicative of greater safety of NSAIDs, but the final decision must be made based on the accumulated data of clinical trials and meta-analyzes. |
| first_indexed | 2024-12-11T09:12:05Z |
| format | Article |
| id | doaj.art-16cc668f4d774f02b7b34fedc19dc14d |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-11T09:12:05Z |
| publishDate | 2019-01-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-16cc668f4d774f02b7b34fedc19dc14d2022-12-22T01:13:28Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422019-01-0191110811310.26442/00403660.2019.01.00003929706Safety of nonsteroidal anti-inflammatory drugs in patients with cardiovascular riskA V Naumov0O N Tkacheva1N O Khovasova2N.I. Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation, Department of diseases of aging. Russian clinical investigator center of gerontologiesN.I. Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation, Department of diseases of aging. Russian clinical investigator center of gerontologiesN.I. Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation, Department of diseases of aging. Russian clinical investigator center of gerontologiesThe review presents current information on the role of NSAIDs in the development of cardiovascular disasters. The development of non-desirable cardiovascular effects and an increase in cardiovascular risk with the administration of NSAIDs, most experts assess in terms of the antagonistic effect on the platelet-vascular homeostasis of metabolites of COX-thromboxane A2 and prostaglandin I2 (prostacyclin). All the presented reviews confirming an increase in the risk of MI complications in the administration of NSAIDs, indicate the class-specificity of this undesirable effect, not homogeneous for different representatives of the group. Important clinical aspects of prescribing NSAIDs for patients with low and moderate cardiovascular risk are the clinical features of the patient and the individual set of risk factors for CVD. Such pharmacokinetic characteristics of NSAIDs as a short half-life, a high degree of binding to blood plasma albumins are indicative of greater safety of NSAIDs, but the final decision must be made based on the accumulated data of clinical trials and meta-analyzes.https://ter-arkhiv.ru/0040-3660/article/viewFile/32955/pdfnonsteroidal anti-inflammatory drugscardiovascular diseasescardiovascular risklornoxicamdiclofenac sodiumthromboelastogrammyocardial infarctionstroke |
| spellingShingle | A V Naumov O N Tkacheva N O Khovasova Safety of nonsteroidal anti-inflammatory drugs in patients with cardiovascular risk Терапевтический архив nonsteroidal anti-inflammatory drugs cardiovascular diseases cardiovascular risk lornoxicam diclofenac sodium thromboelastogram myocardial infarction stroke |
| title | Safety of nonsteroidal anti-inflammatory drugs in patients with cardiovascular risk |
| title_full | Safety of nonsteroidal anti-inflammatory drugs in patients with cardiovascular risk |
| title_fullStr | Safety of nonsteroidal anti-inflammatory drugs in patients with cardiovascular risk |
| title_full_unstemmed | Safety of nonsteroidal anti-inflammatory drugs in patients with cardiovascular risk |
| title_short | Safety of nonsteroidal anti-inflammatory drugs in patients with cardiovascular risk |
| title_sort | safety of nonsteroidal anti inflammatory drugs in patients with cardiovascular risk |
| topic | nonsteroidal anti-inflammatory drugs cardiovascular diseases cardiovascular risk lornoxicam diclofenac sodium thromboelastogram myocardial infarction stroke |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/32955/pdf |
| work_keys_str_mv | AT avnaumov safetyofnonsteroidalantiinflammatorydrugsinpatientswithcardiovascularrisk AT ontkacheva safetyofnonsteroidalantiinflammatorydrugsinpatientswithcardiovascularrisk AT nokhovasova safetyofnonsteroidalantiinflammatorydrugsinpatientswithcardiovascularrisk |